Nail manifestations in pemphigus vulgaris

Cahali, Juliana Burihan; Kakuda, Everton Yuji Soyama; Santi, Cláudia Giuli; Maruta, Celina Wakisaka

doi:10.1590/s0041-87812002000500007

Cited by 19 publications

(15 citation statements)

References 12 publications

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“…12 Moreover, the association of methotrexate, dicloxacillin, oral steroids, and periodic intralesional corticosteroid injections were effective in a relatively resistant scalp disease. 13 The vermillion and nail involvement, as well as the verrucous, hyperkeratotic acral plaques seen in this patient were also described in other cases of pemphigus vulgaris\vegetans, [6][7][8] and these should be considered, together with the classical vegetant lesions in the skin folds, characteristic of the verrucous variant of this condition. …”

Section: Letter To the Editors Pemphigus Vegetans Associated With Versupporting

confidence: 56%

Pemphigus Vegetans Associated With Verrucous Lesions - Expanding a Phenotype

Almeida¹,

Neugebauer²,

Guarenti³

et al. 2006

Clinics

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Section: Letter To the Editors Pemphigus Vegetans Associated With Versupporting

confidence: 56%

Pemphigus Vegetans Associated With Verrucous Lesions - Expanding a Phenotype

Almeida¹,

Neugebauer²,

Guarenti³

et al. 2006

Clinics

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“…Moreover, Cahali et al (2002) reported that no patient exclusively displayed toenail alterations in their series of five PV patients, whereas we observed 5 patients with toenail alterations exclusively and 4 patients with only fingernail affliction.…”

Section: Discussioncontrasting

confidence: 44%

“…Cahali et al (2002) reported S. aureus positive cultures in 2 out of 5 PV patients and paronychia was the primary nail alteration. Although S. aureus was the most common bacteria in our PV patients, bacterial cultures also demonstrated the presence of other organisms.…”

Section: Discussionmentioning

confidence: 96%

Nail changes in female pemphigus vulgaris patients on immunosuppressive therapy

El-Komy

Halim

Samir

et al. 2015

International Journal of Women's Dermatology

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BackgroundPemphigus vulgaris (PV) patients receiving immunosuppressive therapy may develop nail alterations resulting from infection, skin disorder, or drug regimen.ObjectiveThis study aims to describe nail changes in PV female patients receiving immunosuppressive therapy and to report the frequency of associated fungal and bacterial growth in the patients’ nails.MethodsTwenty-five female PV patients who had at least one acquired finger or toenail abnormality and had been administered at least one immunosuppressive drug were included in the study. Nail alterations were recorded. Nail scrapings were collected from abnormal nails for fungal and bacterial examination.ResultsPositive fungal and bacterial cultures were detected in 20 (80%) of patients’ nail samples. Five patients reported nail alterations coinciding with disease onset, whereas 13 reported nail changes after administration of immunosuppressive therapy.LimitationsLack of a control group (patients on similar immunosuppressive medications for conditions other than PV) which would have further supported the findings demonstrated in this observational study.ConclusionNail abnormalities in severe PV patients are frequently associated with fungal and bacterial growth. Immunosuppressive therapy potentially initiates such changes.

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“…idiopathic thrombocytopenia) [9], ichthyosis vulgaris [10,11], immune dysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) [12], immunoglobulin A deficiency [13], incontinentia pigmenti (Bloch-Sulzberger syndrome) [14], pemphigus vulgaris [15], primary biliary cirrhosis [16], reflex sympathetic dystrophy [17], and sarcoidosis [18,19]. However, for some of these cases, the clinical pictures show nail abnormalities that are different from trachyonychia (table 1).…”

Section: Resultsmentioning

confidence: 99%

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Jacobsen

Tosti

2016

Skin Appendage Disord

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Background/Aims: The term trachyonychia, also known as twenty-nail dystrophy, is used to describe thin, brittle nails with excessive longitudinal ridging. The term twenty-nail dystrophy has been incorrectly applied to other conditions that can affect all twenty nails. Therefore, we have conducted a comprehensive review of the clinical features of trachyonychia and have included a discussion regarding the diagnostic accuracy of this condition in the literature. Methods: In November and December 2015, we conducted a thorough literature search using the following search terms: ‘trachyonychia', ‘twenty nail dystrophy', and ‘sandpaper nails'. Articles that reported the epidemiology, disease associations, clinical presentation, histopathology, and treatment options for trachyonychia were included. Particular attention was given to case reports to identify misdiagnosed cases of twenty-nail dystrophy. Results: Our preliminary search yielded 184 results with 72 unique articles ultimately selected for review. Excluded articles included 27 articles in languages other than English, 18 commentaries or reviews, and 67 irrelevant articles. Twelve additional articles described nail abnormalities clinically different from trachyonychia. Conclusion: Many other conditions can cause widespread nail dystrophy. The specific characteristics of trachyonychia need to be considered to make the diagnosis of twenty-nail dystrophy.

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Nail manifestations in pemphigus vulgaris

Cited by 19 publications

References 12 publications

Pemphigus Vegetans Associated With Verrucous Lesions - Expanding a Phenotype

Pemphigus Vegetans Associated With Verrucous Lesions - Expanding a Phenotype

Nail changes in female pemphigus vulgaris patients on immunosuppressive therapy

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

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