A retrospective serologic survey of hantavirus infections in the county of Cássia dos Coqueiros, State of São Paulo, Brazil

Badra, Soraya Jabur; Maia, Felipe Gonçalves Motta; Figueiredo, Glauciane Garcia de; Santos, Gilberto Sabino dos; Figueiredo, Luíz Tadeu Moraes; Passos, Afonso Dinis Costa

doi:10.1590/s0037-86822012005000005

Cited by 18 publications

(13 citation statements)

References 10 publications

(9 reference statements)

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“…Another study, conducted in cities in the State of Santa Catarina near the border between Brazil and Argentina (Souza et al, 2011), found a much higher seropositivity (3.5%) for IgG antibodies to hantavirus compared with our study; however, most of the HCPS have occurred in this country's southern and southeast regions. Additionally, a retrospective research of hantavirus infection that was performed slightly closer to our region, in the city of Cássia dos Coqueiros, State of Sao Paulo, found positive results in 4.7% of the samples (Badra et al, 2012). Lastly, in another South American study in Chile, the researchers found a similar seroprevalence (0.72%) of antibodies to the Andes virus (Frey et al, 2003).…”

Section: Discussionsupporting

confidence: 60%

A Seroepidemiological Survey of Hantavirus in Ilheus County

Moreli

Costa

Pariz

2012

American Journal of Virology

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Hantaviral diseases are infections caused by a group of viruses that belong to the genus hantavirus and the family Bunyaviridae. In Brazil, several cases of hantavirus have been detected with the use of serological methods including immunofluorescence and Enzyme-Linked Immunosorbent Assay (ELISA). To date, 1.573 cases have been reported in several states across the country with a fatality rate of 41%. No seroepidemiologic study has ever been conducted in the city of, or region surrounding, Ilheus, where large remnants of the Atlantic Forest provide shelter for a variety of rodents. The authors used the N recombinant protein of Araraquara virus as antigen to test for the presence of hantavirus-specific IgG antibodies by ELISA in samples provided by blood donors in the city of Ilheus, State of Bahia. The authors collected blood samples from 500 donors. Among these, 93.6% of the donors came from an urban area and 6.4% were from a rural area. A total of 0.6% of the donors was seropositive for anti-hantavirus IgG antibodies. This positivity was detected only in males at a rate of 1.1%. However, there was no observed association for hantavirus seropositivity between the genders (p = 0.252). There was a higher frequency of seropositive individuals aged between 31 and 40 years (1.6%), although the difference observed was not statistically significant (p = 0.41). There was also a higher rate of seropositive individuals among donors from rural areas (6.6%); the association for seropositivity between participants in rural and urban areas was statistically significant (p = 0.011) by Fisher's exact test (p<0.05). The present study describes Araraquara virus circulation in this region for the first time. The results of this study provide the basis for future investigation of the hantaviruses that are associated with cardiopulmonary syndrome and the other antigenic ally related hantaviruses in this region.

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Section: Discussionsupporting

confidence: 60%

A Seroepidemiological Survey of Hantavirus in Ilheus County

Moreli

Costa

Pariz

2012

American Journal of Virology

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“…Serologic surveys performed on inhabitants of urban areas with positivity ranging around 1%-4% also confirmed that the virus is circulating in these areas and probably the majority of infections have an asymptomatic course [16][17][18].…”

Section: Types Of Hantavirus In Brazil and Their Epidemiological Detementioning

confidence: 72%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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“…In another study conducted in cities near the border between Brazil and Argentina, still in the State of Santa Catarina, they found a 3.5% seroprevalence 11 . The highest reported level of infection with an index of 4.7% was found in the City of Cássia dos Coqueiros, located in the State of São Paulo, in the Southeast region 12 . It is important to point out that most of the HCPS cases occurred in the Southeast of the country, along with the South region.…”

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confidence: 91%

Seropositivity diagnosis for hantavirus in Jataí, Goiás State, Brazil

Moreli

Novaes

Flor³

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Emerging diseases are of great interest, especially those associated with high mortality rates such as hantaviruses. We aimed to conduct a seroepidemiological survey to determine the levels of hantavirus infection. Methods: In-house enzyme-linked immunosorbent assay (ELISA) was used to detect specific antibodies. Results: Of the 429 samples collected, seropositivity of 3.9% to anti-hantavirus immunoglobulin G (IgG) was observed (CI 95%: 2.3-5.7). Moreover, in three cases, immunoglobulin M (IgM) was detected, of which two were diagnosed as hantavirus cardiopulmonary syndrome (HCPS). Conclusions: Our data indicate the considerable occurrence of previous hantavirus infections, highlighting occurrences from sub-clinical cases to HCPS.

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A retrospective serologic survey of hantavirus infections in the county of Cássia dos Coqueiros, State of São Paulo, Brazil

Abstract: Our results showed that hantavirus infections occurred in Cássia dos Coqueiros, completely unrecognized, even before hantaviruses were described in the Americas.

Cited by 18 publications

References 10 publications

A Seroepidemiological Survey of Hantavirus in Ilheus County

A Seroepidemiological Survey of Hantavirus in Ilheus County

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Seropositivity diagnosis for hantavirus in Jataí, Goiás State, Brazil

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