Serologic survey of hantavirus in a rural population from the northern State of Mato Grosso, Brazil

Santos, Ioni Oliveira; Figueiredo, Glauciane Garcia de; Figueiredo, Luíz Tadeu Moraes; Azevedo, Marina Sousa; Novo, Neil Ferreira; Vaz, Celidéia Aparecida Coppi

doi:10.1590/s0037-86822012005000002

Cited by 13 publications

(8 citation statements)

References 11 publications

(12 reference statements)

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“…Therefore, the participants may have been infected with the virus while they were living in those regions. This was also observed in a previous study carried out in MT (12) .…”

supporting

confidence: 89%

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Vieira

Silva

Barreto

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:In Brazil, Mato Grosso (MT) has the highest number of hantavirus cardiopulmonary syndrome cases. Our study aimed to identify anti-hantavirus antibodies in the sera of patients from Sinop, MT, presenting with acute febrile illness. Methods: A retrospective analysis of data for 198 sera samples assessed using enzyme-linked immunosorbent assay (ELISA) was conducted. Results: Immunoglobulins G (IgGs) against the hantavirus nucleoprotein were found in 13.6% of the tested sera. No sample had immunoglobulin M (IgM) antibodies to hantavirus. Seropositivity occurred mainly in female residents in urban areas who worked around the household. Conclusions: Our findings suggest circulation of hantavirus in Sinop.Keywords: Zoonosis. Serosurvey study. Hantavirus.Hantaviruses (genus Hantavirus, family Bunyaviridae) are emerging zoonotic viruses of great importance for public health. In South America, the rodents of the Sigmodontinae subfamily are reservoirs of these viruses. Some hantaviruses infect humans, causing either hemorrhagic fever with renal syndrome (HFRS) and/or hantavirus cardiopulmonary syndrome (HCPS) (1) .The first cases of HCPS diagnosed in Brazil occurred in 1993. Since then, more than 1,920 cases of hantavirus have been notified in all Brazilian regions, with a case fatality rate of up to 39.5%. Mato Grosso (MT) is the leading state for HCPS cases and accounts for 16.1% of the total notified cases in Brazil. In a previous study conducted in the municipality of Sinop, Mato Grosso State, we carried out an epidemiological surveillance for arboviruses in 198 sera samples from patients presenting with acute febrile illness and clinical-epidemiological diagnoses of dengue. The results showed 46 samples positive for arboviruses. However, it was intriguing that more than 70% of the patients did not have dengue or other arbovirus infections that were tested for (2) . To address the possibility of hantavirus infection, we investigated the presence of antibodies against the hantavirus nucleoprotein in these febrile patients.Sinop is a municipality located 503km from the capital Cuiabá, in a geographical transition zone between a savannah and rainforest. The city was founded in 1974 and currently has an estimated population of approximately 130,000 inhabitants with 17.1% of them living in rural areas. The economic activities include an intensive agriculture based on the grain production, animal husbandry, logging, and human services. All of the sera analyzed in this study were part of the serum bank of the Laboratory of Immunology and Molecular Biology of Universidade Federal de Mato Grosso (UFMT), Campus of Sinop, which have been previously described in detail (2) . At the time of blood collection, the patients filled out a questionnaire that contained their epidemiological data, sex, age, occupation, address and region of birth, as well as information about any contact with rural or forested areas, and contact with rodents. These data were collected to analyze the risk factors associated with infect...

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“…Therefore, the participants may have been infected with the virus while they were living in those regions. This was also observed in a previous study carried out in MT (12) .…”

supporting

confidence: 89%

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Vieira

Silva

Barreto

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…This result is similar to those found in previous studies 17,19,20 and could be associated with occupational risks, since men usually perform activities such as food storage (grain), the cleaning of sheds and sites, trash collection and weeding, both in rural and urban areas 20 .…”

Section: Resultssupporting

confidence: 91%

Serosurveillance for hantavirus in urban and rural workers in Pernambuco State, Brazil

Silva

Oliveira

Santos³

et al. 2016

Rev Pan-Amaz Saude

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“…20 investigated rural settlements in Goiás (Brazil), and found 2.57% (n=12) positive rate for Orthohantavirus, equally distributed between women and men (n=6). In contrast, similar studies showed higher frequency in middle-aged men due to their risk behaviors 21,22 .…”

Section: Introductionmentioning

confidence: 79%

Synanthropic rodents as virus reservoirs and transmitters

Gravinatti

Barbosa

Soares

et al. 2020

Rev. Soc. Bras. Med. Trop.

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This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies.

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Serologic survey of hantavirus in a rural population from the northern State of Mato Grosso, Brazil

Cited by 13 publications

References 11 publications

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Serological evidence of hantavirus infection in an urban area in Mato Grosso State, Brazil

Serosurveillance for hantavirus in urban and rural workers in Pernambuco State, Brazil

Synanthropic rodents as virus reservoirs and transmitters

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