The new Tropical Medicine

Costa, Carlos Henrique Nery

doi:10.1590/s0037-86822012000100001

Cited by 3 publications

(1 citation statement)

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“…It performs well over a range of endemic settings and would be best applied to monitor the incidence of “new” infections in young children in environments where transmission was thought to be interrupted [21]. The most important point to be considered is that the use of different antigens in immunological methods can be applied as potential tools for the analysis of the chronological evolution of S. mansoni infection [32]. Recent analysis has shown that the antigens from different life stages as schistosomula, adult worms, and eggs can be markers for prepatent, acute and chronic phases.…”

Section: Immunodiagnostic Methods For Antibodies Detectionmentioning

confidence: 99%

Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?

Grenfell

Silva-Moraes

Taboada

et al. 2012

The Scientific World Journal

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Worldwide Schistosomiasis mansoni continues to be a serious public health problem. Over the past decades, control programmes have made remarkable progress in reducing S. mansoni infections to a relatively low level in Brazil and African countries. Endemic regions are currently circumscribed in certain core areas where reinfection and repeated chemotherapy are frequent and, consequently, are related to residents with low parasite load. At present, diagnosis is predominately a key step for final disease control although low endemicity area residents are hardly detected by most of the available assays. In this paper, we review the current status and efforts made aiming at the improvement of diagnostic tools for S. mansoni in low endemicity infections. The establishment of diagnostic assays—simple, affordable, sensitive, and specific for field diagnosis of S. mansoni—is essential and should be given high priority.

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Section: Immunodiagnostic Methods For Antibodies Detectionmentioning

confidence: 99%

Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?

Grenfell

Silva-Moraes

Taboada

et al. 2012

The Scientific World Journal

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Detection and quantification of Leishmania braziliensis in ectoparasites from dogs

Morais

Gonçalves-de-Albuquerque

Silva

et al. 2013

Veterinary Parasitology

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American cutaneous leishmaniasis (ACL) is a disease caused by different species of Leishmania protozoa, Leishmania braziliensis being the main species found in Brazil. In this study, two rural areas in Pernambuco, northeastern Brazil, where ACL is endemic, were selected. Genomic DNA was extracted from canine ectoparasites (ticks, fleas, and lice) and tested using a conventional PCR and a quantitative real time PCR. A total of 117 ectoparasites were collected, being 50 (42.74%) of them positive for L. braziliensis (in at least one PCR protocol), with a mean parasite load of 14.14 fg/μL. Furthermore, 46 (92.00%) positive ectoparasites were collected from positive dogs and 4 (8.00%) from negative ones. This study reports the detection of L. braziliensis DNA in ectoparasites, but does not prove their vector competence. Certainly, experimental transmission studies are necessary to assess their role, if any, in the transmission of Leishmania parasites to dogs.

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The importance of originality in scientific research on neglected tropical diseases

Teixeira

2013

Rev. Soc. Bras. Med. Trop.

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The new Tropical Medicine

Cited by 3 publications

References 1 publication

Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?

Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?

Detection and quantification of Leishmania braziliensis in ectoparasites from dogs

The importance of originality in scientific research on neglected tropical diseases

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