Acetylcholinesterase inhibition starting from extracts of Bauhinia variegata L., Bauhinia var. candida (Aiton) Buch.-Ham., and Bauhinia ungulata L

Santos, Kamilla Monteiro dos; Gonçalves, Priscila Sant'Ana; Paiva, Maria José Nunes de; Lacerda, Guilherme Araújo

doi:10.1590/s0037-86822011000600025

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…Bauhinia plant extracts or fractions have also shown antitumor and/or chemoprotective effects. For instance, B. ungulata extracts of stems, enriched in flavonoids and alkaloids, inhibited the activity of matrix metalloproteinases MMP-2 and MMP-9, which cleave the main structural components of the basal membrane and have a prognostic influence on human cancers [ 121 ]. More recently, Ribeiro et al [ 98 ] found that B. holophylla hydroalcoholic extract induced apoptosis and showed high antiproliferative effects in Hep-G2 cells.…”

Section: Biological Activitymentioning

confidence: 99%

“Cow’s Hoof” (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species

Fortunato

Nores

2022

Plants

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The genus Bauhinia s.l. (Leguminosae), known as cow’s hoof, unha de boi or pata de vaca, has been used in traditional medicine worldwide. The aim of the present review is to summarize the studies published on the biological activity of the main native medicinal species reported in austral South America. Of the 14 species present in the region, 10 are consumed as leaf infusions to regulate glucose and lipid metabolism, as well as used for their anti-inflammatory and analgesic effects and to treat various diseases. Pharmacological properties have been recorded in seven species. Antioxidant, anticoagulant, antihypertensive, diuretic, antimicrobial and antitumor properties have been reported in B. forficata. Together with B. holophylla, they are important for their antidiabetic properties, since several studies indicate their effectiveness as a hypoglycemic agent. B. bauhinioides is distinguished for its anti-inflammatory and antithrombotic activities and S. microstachya for its analgesic properties. Anti-ulcer and wound healing activities recorded in B. holophylla and B. ungulata, respectively, are of particular interest. Most of the species possess antitumor activity. The antioxidant capacity of flavonoids and other bioactive compounds make these plants good candidates to assist or treat various alterations related with oxidative stress, such as diabetic complications. Thus, these species constitute promising targets for new bioactive substance research and phytotherapy.

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Section: Biological Activitymentioning

confidence: 99%

“Cow’s Hoof” (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species

Fortunato

Nores

2022

Plants

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“…[1] Species of the genus Bauhinia are present as trees, shrubs and vines, and in Brazil are used by the population as hypoglycemic agents. [2] Multiple biological activities are allocated to Bauhinia species such as antidiabetic, diuretic, hypocholesterolemic, antimicrobial, analgesic, antioxidant, larvicidal, acetylcholinesterase, anti-inflammatory,[234567] among others. Chemical compositions of essential oils of Bauhinias are cited in the literature, among them Bauhinia aculeata , B. brevipes , B. forficata , B. longifolia , B. pentandra , B. rufa , B. variegata , B. ungulata and B. acuruana .…”

Section: Introductionmentioning

confidence: 99%

Chemical composition of the essential oil and fixed oil Bauhinia pentandra (Bong.) D. Dietr

Almeida¹,

Souza²,

Ferreira³

et al. 2015

Phcog Mag

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Background:Bauhinia pentandrais popularly known as “mororó” and inhabits the Caatinga and Savannah biomes.Objective:This paper reports the chemical composition of the essential and fatty oils of the leaves from B. pentandra.Materials and Methods:The essential oil was obtained by hydrodistillation and the fixed oil by extraction with hexane, followed by saponification with KOH/MeOH, and methylation using MeOH/HCl. The constituents were analyzed by gas chromatography-mass spectrometry.Results:The major constituent of the essential oil was the phytol (58.78% ±8.51%), and of the fatty oil were palmitic (29.03%), stearic (28.58%) and linolenic (10.53%) acids.Conclusion:Of the compounds identified in the essential oil, three are first reported in this species, and this is the first record of the chemical composition of the fixed oil.

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“…Na Índia, praticamente todas as partes do vegetal são usadas pelo sistema da medicina Ayurvédica no tratamento de doenças, como: febre, lepra, feridas e tumores 5 . Um estudo recente revelou potencial capacidade de inibição de colinesterases 6 . Deste modo, devido à possível ação antitumoral e de inibição enzimática por partes isoladas de diferentes espécies de Bauhinia e tendo em vista que a inibição de metaloproteinases por extratos de plantas pode ser um mecanismo para evitar a metástase de células neoplásicas, é de extrema relevância que seja avaliada a atividade dos extratos da espécie escolhida sobre a atividade de MMP-2 e MMP-9.…”

Section: Introductionunclassified

Caracterização e atividade de extratos de plantas de uma espécie de Bauhinia sobre a ação de Metaloproteinases

Santos

Nunes

Gomes

et al. 2013

BBR - Biochem. Biotechnol.

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Acetylcholinesterase inhibition starting from extracts of Bauhinia variegata L., Bauhinia var. candida (Aiton) Buch.-Ham., and Bauhinia ungulata L

Abstract: The flower extract of B. ungulata is the most suitable for further studies on this inhibition.

Cited by 8 publications

References 5 publications

“Cow’s Hoof” (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species

“Cow’s Hoof” (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species

Chemical composition of the essential oil and fixed oil Bauhinia pentandra (Bong.) D. Dietr

Caracterização e atividade de extratos de plantas de uma espécie de Bauhinia sobre a ação de Metaloproteinases

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