Hepatitis B marker seroprevalence and vaccination coverage in adolescents in the City of Itajaí, State of Santa Catarina, Southern Brazil, in 2008

Tonial, Gabriela Chiochetta; Passos, Ana Maria; Livramento, Andréa do; Scaraveli, Natália Gazzoni; Batschauer, Anna Paula de Borba; Bueno, Ednéia Casagranda; Largura, Álvaro; Spada, Celso; Treitinger, Arício

doi:10.1590/s0037-86822011000400003

Cited by 15 publications

(14 citation statements)

References 29 publications

(27 reference statements)

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“…Additionally, this prevalence is also similar to the rate found in adolescents with immunization rates up to 98% in the state (1.4% and 0.6%) Tonial et al, 2011), the rate reported in Portugal for adolescents with a mean age of 14 years old (0.6%) (Antunes, Macedo, Estrada, 2004), and the rate reported in Italy for individuals up to 24 years old (1.0%) (Fabris et al, 2008); however, it is inferior to the rate reported by Nascimento et al (2008) in first-time eligible blood-donors from north, northeast and southeast Brazil (2.9%) and to the rate found in blood donors in south Brazil (15.6%) (Martelli et al, 1999) and the MRF (4.5%) (Rosini et al, 2003).…”

Section: Discussionsupporting

confidence: 84%

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

Passos

Neto

Treitinger

et al. 2012

Braz. J. Pharm. Sci.

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We investigated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) serological markers of infection in young adults from the metropolitan region of Florianópolis who were conscripts of the Air Base of Florianópolis in the state of Santa Catarina, Brazil. A population-based cross-sectional seroprevalence study was conducted with 371 young males during a one year period starting in June 2009. Demographic characteristics, socio-economic characteristics and possible risk factors to HBV and HCV were assessed. Blood samples were analyzed for HBsAg, anti-HBc, anti-HCV and anti-HBs through automated microparticle enzymatic immunoassays (Abbott®, AxSYM System, Wiesbaden, Germany). None of the participants showed positivity to HBsAg or anti-HCV. The prevalence of anti-HBc was 1.6% (95% CI 0.6 -3.5), and the prevalence of anti-HBs was 40.7% (95% CI 35.7 -45.9). Unsafe sex was associated with positive anti-HBc in a bivariate analysis. There was a very low prevalence of past HBV infection and no cases of past HCV infection in a young adult population in the metropolitan region of Florianópolis. The very low prevalence of markers of infection and risk factors indicates a very optimistic future with respect to HBV and HCV infection in this population.Uniterms: HBV. HCV. Hepatitis B. Hepatitis C. Seroprevalence.Este estudo teve como objetivo investigar a prevalência dos marcadores sorológicos de infecção pelo HBV e HCV em adultos jovens na Região Metropolitana de Florianópolis, conscritos da Base Aérea de Florianópolis, Santa Catarina, Brasil. Trata-se de um estudo soroepidemiológico transversal de base populacional com 371 adultos jovens, no período de um ano a partir de junho de 2009. Foram pesquisadas características sócio-econômicas e possíveis fatores de risco para HBV e HCV. As amostras de sangue foram analisadas quanto à presença de HBsAg, anti-HBc, anti-HCV e anti-HBs pelo método imunoensaio enzimático automatizado de micropartículas (Abbott®, Sistema AxSYM, Wiesbaden, Alemanha). Nenhum dos participantes demonstrou positividade para HBsAg ou anti-HCV. A prevalência do anti-HBc foi de 1,6% (IC 95% 0,6 -3,5) e do anti-HBs foi 40,7% (IC 95% 35,9). Relação sexual desprotegida associou-se com a positividade do anti-HBc na análise bivariada. Demonstrou-se prevalência muito baixa de infecção passada pelo HBV e ausência de HCV nesta população de adultos jovens na Região Metropolitana de Florianópolis. A particularidade desta prevalência muito baixa de marcadores de infecção e fatores de risco aponta para um quadro otimista em relação ao HBV e HCV no futuro para esta população.Unitermos: HBV. HCV. Hepatite B. Hepatite C. Soroprevalência.

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Section: Discussionsupporting

confidence: 84%

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

Passos

Neto

Treitinger

et al. 2012

Braz. J. Pharm. Sci.

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“…[23][24][25]29,30 However, it is important to point out that the comparison of results is difficult as the maintenance of anti-HBs titers may be influenced by the time elapsed since vaccination and the level of exposure to hepatitis B virus. 31 The rates of HIV-infected individuals who develop anti-HBs levels ≥10 IU/L after receiving the standard, accelerated, or four double-dose schedules are variable, ranging from 38.7% to 91.0%.…”

Section: Discussionmentioning

confidence: 99%

Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil

Martins

Livramento

Andrigueti

et al. 2015

The Brazilian Journal of Infectious Diseases

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Evidence-based strategies to improve the hepatitis B virus (HBV) vaccination coverage rates might help to reduce the burden caused by co-infection with HBV and human immunodeficiency virus (HIV). In this study, the aim was to evaluate the vaccination coverage and immunity against HBV among HIV-infected individuals in South Brazil, and identify factors that are associated with compliance patterns and antibody reactivity. Three hundred HIV-infected men and women were included in this survey. The patients answered a standardized questionnaire, and vaccination cards were checked in order to assess hepatitis B vaccine status. A blood sample was collected for quantitative determination of antibody to hepatitis B virus surface antigen (anti-HBs). Participants were also evaluated for their CD4 cell count and HIV viral load. The overall vaccination coverage of HBV vaccination found in this study (57.4%) was lower than that was previously reported in South Brazil. Anti-HBs levels >10IU/L were observed in 47.0% of the studied population. A significant inequality in the coverage rates and antibody reactivity was found in favor of patients with better economic status. In conclusion, the results indicate the need for improvement in the HBV vaccination coverage among HIV carriers, in particular focusing on low-income individuals.

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“…The long-term maintenance of immune memory is highly advantageous as it can provide an immediate response to pathogens to which the host has been previously exposed. Despite the level of anti-HBs after inoculation with three doses of the HBV vaccine (<10 IU/L; Livramento et al, 2011;Scaraveli et al, 2011;Tonial et al, 2011), the implementation of the universal HBV vaccination program significantly reduced the incidence of HBsAg carriers and HBV-related diseases (Chongsrisawat et al, 2006;Tosun et al, 2011). The survival of a memory cell has the potential to continuously stimulate the antigen.…”

Section: Discussionmentioning

confidence: 99%

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

Hou¹,

Li²,

Wei³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononuclear cells were stimulated with 50 ng/mL recombinant HBsAg. An ELISA kit was used for the detection of antibodies that were produced by these cells in vitro. It was found that even 13-18 years after inoculation with the HBV vaccine, an anamnestic antibody response still existed, and was not correlated with the serum antibody levels (r = -0.177, P = 0.377).In conclusion, our data showed that the individuals after inoculation, including those with anti-HBs <10 IU/L as well as those individuals in whom the antibody was not detected, retained immune memory, which may be the main role of memory B cells.

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Hepatitis B marker seroprevalence and vaccination coverage in adolescents in the City of Itajaí, State of Santa Catarina, Southern Brazil, in 2008

Cited by 15 publications

References 29 publications

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil

Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil

Immune memory responses to HBV vaccine 13-18 years after primary vaccination

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