Declínio da prevalência do HTLV-1/2 em doadores de sangue do Hemocentro Regional da Cidade de Uberaba, Estado de Minas Gerais, 1995 a 2008

Lima, Guilherme Manso de; Eustáquio, José Martins Juliano; Martins, Raquel A.; Josahkian, Juliana Alves; Pereira, Gilberto de Araújo; Moraes‐Souza, Helio; Martins, Paulo Roberto Juliano

doi:10.1590/s0037-86822010000400017

Cited by 7 publications

(6 citation statements)

References 19 publications

(19 reference statements)

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“…No positivity occurred in the current study and it should be emphasized that infection by the virus is in sharp decline according to studies of blood donors in Uberaba, Minas Gerais which assessed the prevalence of HTLV-I and II between 1995 and 2008. The prevalence for 1995-2000 was 0.6%, whereas it declined to 0.1% during the 2002-2008 period (27) .…”

Section: Discussionmentioning

confidence: 99%

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Borelli¹,

Mazzola²,

Matta³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundSo that an improvement in the selection of donors can be achieved and the risk to the recipient of transfused blood can be reduced, prospective donors are submitted to clinical and serological screening. ObjectiveThis study investigated the blood discard rate and the rate of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil. MethodsThis study was an exploratory cross-sectional descriptive investigation with a quantitative approach of donations between January and December 2011. ResultsIn the study period the Regional Blood center in Maringá, Brazil received 8337 blood donations from people living in the city and neighboring towns. However, 278 (3.33%) donations were discarded during serological screening owing to one or more positive serological markers. A total of 46.4% of the discarded blood units were confirmed positive by serology with anti-HBc being the most common (66.7%), followed by syphilis (22.5%), HBsAg (4.7%), anti-hepatitis C virus (3.1%), human immunodeficiency virus (1.5%) and Chagas' disease (1.5%). The rate of infectious-contagious diseases that can be transmitted by blood transfusions was 1.55% (129/8337) of the donor population with a frequency of 1.03% for anti-HBc and 0.35% for syphilis. ConclusionThis study demonstrates a high prevalence of the anti-HBc marker in prospective blood donors from provincial towns in the state of Paraná, Brazil.

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Section: Discussionmentioning

confidence: 99%

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Borelli¹,

Mazzola²,

Matta³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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“…Later on, blood bank screening was applied in developing countries with medium to high seroprevalence among blood donors (Argentina: 2004, Peru: 1999). This policy proved to be successful to decrease HTLV-1 spread by blood transfusion [300–304]. Unfortunately, official screening programs still lack in other regions with high prevalence (Middle East) [305,306], further reflecting differences between industrialized and developing countries.…”

Section: Blv As a Model For Htlv Therapy And Preventionmentioning

confidence: 99%

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Rodríguez

Florins

Gillet

et al. 2011

Viruses

170

120

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Bovine leukemia virus (BLV) is a retrovirus closely related to the human T-lymphotropic virus type 1 (HTLV-1). BLV is a major animal health problem worldwide causing important economic losses. A series of attempts were developed to reduce prevalence, chiefly by eradication of infected cattle, segregation of BLV-free animals and vaccination. Although having been instrumental in regions such as the EU, these strategies were unsuccessful elsewhere mainly due to economic costs, management restrictions and lack of an efficient vaccine. This review, which summarizes the different attempts previously developed to decrease seroprevalence of BLV, may be informative for management of HTLV-1 infection. We also propose a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.

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“…HTLV types 1 and 2 present tropism for CD4 + and CD8 + T lymphocytes, respectively. In Brazil, these serotypes are the most common in the population (1,2) . The main forms of transmission are unprotected sex, congenital and/or parenteral, with the latter being associated with transfusions and contaminated needles (3) .…”

Section: Introductionmentioning

confidence: 99%

“…The methods used to detect IgG, IgM and IgA anti-HTLV in the screening phase of blood banks are agglutination of latex particles, enzyme linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). Western Blot (WB) and polymerase chain reaction (PCR) are used in the confirmatory phase (1,3) . The introduction of screening tests for HTLV-1/2 over the last 25 years was very important as this has excluded seropositive blood donors resulting in a lower rate of infections among blood recipients thereby reducing the number of new infections in the general population (4) .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human T-cell lymphotropic virus types 1 and 2 in blood donors of the Caruaru Blood Center (Hemope)

Lima¹,

Esteves²,

Torres³

et al. 2013

Revista Brasileira De Hematologia E Hemoterapia

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BackgroundThere is difficulty in gathering data on the prevalence of human T-cell lymphotropic virus in blood donors as confirmatory testing is not mandatory in Brazil. This suggests there may be an underreporting of the prevalence. ObjectiveTo estimate the prevalence of human T-cell lymphotropic virus types 1 and 2 in donors of a blood bank in Caruaru, Brazil. MethodsThis was an observational, epidemiological, descriptive, longitudinal and retrospective study with information about the serology of donors of the Caruaru Blood Center, Fundação de Hematologia e Hemoterapia de Pernambuco (Hemope) from May 2006 to December 2010. The data were analyzed using the Excel 2010 computer program (Microsoft Office®). ResultsOf 61,881 donors, 60 (0.096%) individuals were identified as potential carriers of human T-cell lymphotropic virus types 1 and 2. Of these, 28 (0.045%) were positive and 32 (0.051%) had inconclusive results in the serological screening. Forty-five (0.072%) were retested; 17 were positive (0.027%) and 3 inconclusive (0.005%). After confirmatory tests, 8 were positive (0.013%). Six (75%) of the confirmed cases were women. ConclusionEpidemiological surveys like this are very important in order to create campaigns to attract donors and reduce the costs of laboratory tests.

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Declínio da prevalência do HTLV-1/2 em doadores de sangue do Hemocentro Regional da Cidade de Uberaba, Estado de Minas Gerais, 1995 a 2008

Cited by 7 publications

References 19 publications

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil

Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV

Prevalence of human T-cell lymphotropic virus types 1 and 2 in blood donors of the Caruaru Blood Center (Hemope)

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