Prevalência da doença de Chagas em gestantes da região sul do Rio Grande do Sul

Araújo, Anelise Bergmann; Castagno, Victor Delpizzo; Gallina, Tiago; Berne, Maria Elisabeth Aires

doi:10.1590/s0037-86822009000600024

Cited by 10 publications

(8 citation statements)

References 14 publications

(6 reference statements)

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“…The remainder (n=27) made the diagnosis with other or mixed methods, including one or a combination of direct microscopy, serology, PCR, hemoculture, and xenodiagnoses. Sample sizes varied greatly from 1 30,31 to 4377 infants, 32 while the number of diagnosed congenital cases ranged from 0 (n=13 studies) to 267 infants. 32 After excluding the studies without congenital infections, the congenital transmission rates ranged from 0.75% 33 to 28.6%.…”

Section: Resultsmentioning

confidence: 99%

Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta‐analysis

Howard

Xiong

Carlier

et al. 2013

BJOG

213

156

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Background Chagas disease is caused by the parasite Trypanosoma cruzi and endemic in much of Latin America. With increased globalization and immigration, it is a risk in any country due in part to congenital transmission. The frequency of congenital transmission is unclear. Objective To assess the frequency of congenital transmission of T. cruzi. Search Strategy PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or Trypanosoma cruzi and congenital transmission. Selection Criteria The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. Data Collection and Analysis Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure – the congenital transmission rate – is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was utilized. Main Results The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9–5.6%). Endemic countries had a higher rate of congenital transmission compared to non-endemic (5.0% vs. 2.7%). Conclusions Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.

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Section: Resultsmentioning

confidence: 99%

Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta‐analysis

Howard

Xiong

Carlier

et al. 2013

BJOG

213

156

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“…This prevalence is lower than that reported in disease-endemic regions of Argentina and Bolivia, but higher than those reported in Peru and Brazil. [7][8][9] The most relevant T. cruzi infection risk-associated factors were age, knowledge of vector, rural residency and level of education. Similarly, Hidron and others using a multivariate model reported that longer residence in a disease-endemic province, residence in a rural area, and poor housing conditions were associated with T. cruzi infection.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, in Bolivia it varies from 20% to 60% and in Argentina, Brazil, Chile, Peru, and Paraguay it ranges from 0% to 40%. [7][8][9] Likewise, the probability of congenital transmission varies among countries because it is dependent on follow-up time for newborns and diagnostic techniques used, which usually differ from one study to another. [10][11][12] In Colombia, there are approximately 436,000 infected persons, nearly 5 million persons live in areas at risk for vector-borne domestic transmission, Chagas disease affects closely 130,000 women of childbearing age, and consequently, near 1,000 children with congenital Chagas disease are born annually.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors for Chagas Disease in Pregnant Women in Casanare, Colombia

Cucunubá

Flórez²,

Cárdenas³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Knowledge of the prevalence and risk factors associated with maternal infection is the first step to develop a surveillance system for congenital transmission of Chagas disease. We conducted a cross-sectional study in Casanare, a disease-endemic area in Colombia. A total of 982 patients were enrolled in the study. A global prevalence of Trypanosoma cruzi infection of 4.0% (95% confidence interval [CI] = 2.8-5.3%) was found. Multivariate analysis showed that the most important risk-associated factors were age 29 years (adjusted odds ratio [aOR] = 3.4, 95% CI = 0.9-12.4), rural residency (aOR = 2.2, 95% CI = 1.0-4.6), low education level (aOR = 10.2, 95% CI = 1.6-82.7), and previous knowledge of the vector (aOR = 2.2, 95% CI = 1.0-4.9). Relatives and siblings of infected mothers showed a prevalence of 9.3%. These findings may help physicians to investigate congenital cases, screen Chagas disease in siblings and relatives, and provide early treatment to prevent the chronic complications of Chagas disease.

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“…Araujo et al [26] conducted an epidemiological study of CD involving pregnant women from the Brazilian town of Pelotas (Rio Grande do Sul state). A total of 351 umbilical cord serum samples obtained from the parturients were analyzed and only one case was positive.…”

Section: Reviewmentioning

confidence: 99%

Challenges and perspectives of Chagas disease: a review

Pereira

Navarro

2013

J Venom Anim Toxins incl Trop Dis

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Chagas disease (CD), also known as American trypanosomiasis, is caused by the flagellated protozoan Trypanosoma cruzi, and affects an estimated 8 to 10 million people worldwide. In Latin America, 25 million people live in risk areas, while in 2008 alone, 10,000 CD-related deaths were reported. This review aimed to evaluate the challenges of CD control, future perspectives, and actions performed worldwide to control expansion of the disease and its impact on public health in Latin America.

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Prevalência da doença de Chagas em gestantes da região sul do Rio Grande do Sul

Cited by 10 publications

References 14 publications

Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta‐analysis

Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta‐analysis

Prevalence and Risk Factors for Chagas Disease in Pregnant Women in Casanare, Colombia

Challenges and perspectives of Chagas disease: a review

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