Portal vein thrombosis in a patient with hepatosplenic schistosomiasis mansoni

Lambertucci, José Roberto; Resende, Vívian; Voieta, Izabela

doi:10.1590/s0037-86822009000200031

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…PVT is a well-known complication following surgical intervention (ie, splenectomy and distal splenorenal shunting) for schistosomiasis and possibly arises due to the fall in portal vein pressure after surgery 17 18. This complication had also been reported in a 46-year-old patient with portal hypertension due to S. mansoni without previous surgery for complications of portal hypertension 19. Despite treatment with PZQ, the patient had to undergo repeated sessions of sclerotherapy for recurrent bleeding from ruptured oesophageal varices.…”

Section: Discussionmentioning

confidence: 81%

Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Olveda¹,

Olveda²,

Montes³

et al. 2014

BMJ Case Reports

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We report for the first time in the Philippines a case of portal vein thrombosis in a 12 year old Filipino boy with advanced schistosomiasis. The boy was referred to the Research Institute for Tropical Medicine (RITM), Manila, due to a rapidly enlarging spleen post-praziquantel treatment. At RITM, liver function tests were within normal limits but complete blood examinations showed pancytopenia and abnormal coagulation times. Serum markers for hepatitis A, B and C were negative. Abdominal MRI revealed schistosome-induced periportal fibrosis. The main portal vein appeared thrombosed with characteristic cavernous transformation of the right portal vein. Varices were seen in the oesophagus, gastrohepatic ligament, and splenic hilum. The spleen was markedly enlarged, with parenchymal foci representing Gamna-Gandy bodies. The patient underwent splenectomy. Histopathologic findings in the liver showed moderate pipestem fibrosis and schistosome egg granulomas. The patient was discharged from the hospital in excellent clinical condition.

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Section: Discussionmentioning

confidence: 81%

Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Olveda¹,

Olveda²,

Montes³

et al. 2014

BMJ Case Reports

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show abstract

“…Severe portal hypertension has been reported in patients with minimal liver fibrosis. However, when imaging techniques or histological evaluations are performed, they do not match the portal hypertension severity diagnosis (8,(12)(13)(14). A marked increase in hepatic and PAH resistance is a primary factor in portal hypertension and pulmonary development, respectively.…”

Section: Introductionmentioning

confidence: 99%

Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis

Botoni,

Lambertucci,

Santos

et al. 2024

Front. Immunol.

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IntroductionSchistosomiasis (SM) is a parasitic disease caused by Schistosoma mansoni. SM causes chronic inflammation induced by parasitic eggs, with collagen/fibrosis deposition in the granuloma process in the liver, spleen, central nervous system, kidneys, and lungs. Pulmonary arterial hypertension (PAH) is a clinical manifestation characterized by high pressure in the pulmonary circulation and right ventricular overload. This study investigated the production of functional autoantibodies (fAABs) against the second loop of the G-protein-coupled receptor (GPCR) in the presence of hepatic and PAH forms of human SM.MethodsUninfected and infected individuals presenting acute and chronic manifestations (e.g., hepatointestinal, hepato-splenic without PAH, and hepato-splenic with PAH) of SM were clinically evaluated and their blood was collected to identify fAABs/GPCRs capable of recognizing endothelin 1, angiotensin II, and a-1 adrenergic receptor. Human serum was analyzed in rat cardiomyocytes cultured in the presence of the receptor antagonists urapidil, losartan, and BQ123.ResultsThe fAABs/GPCRs from chronic hepatic and PAH SM individuals, but not from acute SM individuals, recognized the three receptors. In the presence of the antagonists, there was a reduction in beating rate changes in cultured cardiomyocytes. In addition, binding sites on the extracellular domain functionality of fAABs were identified, and IgG1 and/or IgG3 antibodies were found to be related to fAABs.ConclusionOur data suggest that fAABs against GPCR play an essential role in vascular activity in chronic SM (hepatic and PAH) and might be involved in the development of hypertensive forms of SM.

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Schistosoma haematobium infection with pulmonary involvement in a traveller returning from Congo: A case report and systematic review of literature on nodular pulmonary schistosomiasis

Mortier

Aubry²,

L’Ollivier³

et al. 2021

Travel Medicine and Infectious Disease

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Portal vein thrombosis in a patient with hepatosplenic schistosomiasis mansoni

Cited by 3 publications

References 2 publications

Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis

Schistosoma haematobium infection with pulmonary involvement in a traveller returning from Congo: A case report and systematic review of literature on nodular pulmonary schistosomiasis

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