Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Olveda, David U.; Olveda, Remigio M.; Montes, Conor Jan; Chy, Delia; Abellera, Jose Modesto B; Cuajunco, Delfin; Lam, Alfred King‐Yin; McManus, Donald P.; Li, Yuesheng; Ross, Allen G.

doi:10.1136/bcr-2014-203897

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…Due to repeated or mass infection of schistosome cercariae, without thorough and timely treatment, patients can evolve into advanced schistosomiasis usually after 2 to 10 years of pathological development process. Clinical symptoms of advanced schistosomiasis include ascites, splenomegaly, portal hypertension, gastro-esophageal variceal bleeding, granulomatous lesions of the large intestine, and serious growth retardation [ 12 , 13 ]. Advanced schistosomiasis japonica is much more common in highly endemic areas, because repeated, heavy exposure to cercariae means that early-stage chronic cases may not be effectively treated in routine control programs.…”

Section: Introductionmentioning

confidence: 99%

Comparison of three data mining models for prediction of advanced schistosomiasis prognosis in the Hubei province

Guo

Zhou

et al. 2018

PLoS Negl Trop Dis

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BackgroundIn order to better assist medical professionals, this study aimed to develop and compare the performance of three models—a multivariate logistic regression (LR) model, an artificial neural network (ANN) model, and a decision tree (DT) model—to predict the prognosis of patients with advanced schistosomiasis residing in the Hubei province.Methodology/Principal findingsSchistosomiasis surveillance data were collected from a previous study based on a Hubei population sample including 4136 advanced schistosomiasis cases. The predictive models use LR, ANN, and DT methods. From each of the three groups, 70% of the cases (2896 cases) were used as training data for the predictive models. The remaining 30% of the cases (1240 cases) were used as validation groups for performance comparisons between the three models. Prediction performance was evaluated using area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy. Univariate analysis indicated that 16 risk factors were significantly associated with a patient’s outcome of prognosis. In the training group, the mean AUC was 0.8276 for LR, 0.9267 for ANN, and 0.8229 for DT. In the validation group, the mean AUC was 0.8349 for LR, 0.8318 for ANN, and 0.8148 for DT. The three models yielded similar results in terms of accuracy, sensitivity, and specificity.Conclusions/SignificancePredictive models for advanced schistosomiasis prognosis, respectively using LR, ANN and DT models were proved to be effective approaches based on our dataset. The ANN model outperformed the LR and DT models in terms of AUC.

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Section: Introductionmentioning

confidence: 99%

Comparison of three data mining models for prediction of advanced schistosomiasis prognosis in the Hubei province

Guo

Zhou

et al. 2018

PLoS Negl Trop Dis

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“…Our hypotheses for the probable cause of death is that peripheral blood eosinophilia caused by the parasitic infection promoted a hypercoagulable state that may have resulted in thrombosis leading to ischemia, bowel infarction, and death, which is in line with previous reports with other parasitic infestations [ 26 ]. Although many studies have found an association between the presence of thrombosis in different body sites with different parasitic infections [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], none have directly linked thrombosis with the Enterobius vermicularis infection.…”

Section: Discussionmentioning

confidence: 99%

Fatal Case of a Child Harboring Enterobius vermicularis

et al. 2023

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Enterobius vermicularis is a threadlike parasite also known as “pinworms”. It is the most common helminth infection, affecting the gastrointestinal tracts of children worldwide, although it seldom causes any fatalities. Enterobius vermicularis infections are usually asymptomatic and may only cause anal pruritis, with occasional reported cases of ectopic migration into the appendix or the female genital tract by adult pinworms. Here, we report a case of a 15-year-old girl who presented to the emergency department with high-grade fever, vomiting, and vague abdominal pain for three days. She was diagnosed with acute abdominal pain and underwent emergency ileocecectomy, but died the following day. Pathological examination of ileocecal junction showed intraluminal and intramural Enterobius vermicularis, which were attributed as the cause of her death in the absence of any other pathologies. Death due to Enterobius vermicularis is rare; this case calls for clinicians to be vigilant in exploring Enterobius vermicularis infections in patients with undiagnosed acute abdominal pain, since it could be a potential cause of death.

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“…<5% of total cases) that will be encountered in the community. 24 Prior to the commencement of integrated control, it is proposed that the Ministry of Health would sign a written agreement that indigent patients can be sent for appropriate referral, and that all medical expenses will be covered by the government's health-care scheme. 23 The state/provincial government should be lobbied to provide for local travel, and a modest living allowance for the spouse or guardian while the patient is undergoing treatment and recovery.…”

Section: Treatment-annual 60 Mg/kg Pzq + 6 Mg/kg Artmentioning

confidence: 99%

A new global strategy for the elimination of schistosomiasis

Ross

Chau

Inobaya

et al. 2017

International Journal of Infectious Diseases

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Mass drug administration utilising a single oral dose of 40mg/kg of praziquantel (PZQ) has been endorsed and advocated by the World Health Organisation (WHO) for the global control and elimination of schistosomiasis. However, this strategy is failing primarily because the drugs are not getting to the people who need them the most. The current global coverage is 20%, the drug compliance rate is less than 50%, and the drug efficacy is approximately 50%. Thus in reality, only about 5% of the reservoir human population is actually receiving intermittent chemotherapy. Despite claims that more of the drug will soon be made available the current strategy is inherently flawed and will not lead to disease elimination. We discuss the many practical issues related to this global strategy, and advocate for an integrated control strategy targeting the life cycle and the most at-risk. Moreover, we discuss how an integrated control package for schistosomiasis should fit within a larger integrated health package for rural and remote villages in the developing world. A holistic health system approach is required to achieve sustainable control and ultimately disease elimination.

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Clinical management of advanced schistosomiasis: a case of portal vein thrombosis-induced splenomegaly requiring surgery

Cited by 10 publications

References 32 publications

Comparison of three data mining models for prediction of advanced schistosomiasis prognosis in the Hubei province

Comparison of three data mining models for prediction of advanced schistosomiasis prognosis in the Hubei province

Fatal Case of a Child Harboring Enterobius vermicularis

A new global strategy for the elimination of schistosomiasis

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