Prevalência de Staphylococcus spp resistentes à meticilina isolados em uma maternidade escola da Cidade de Natal, Estado do Rio Grande do Norte

Júnior, Francisco Canindé de Sousa; Nunes, Éderson William de Figueiredo; Nascimento, Ermeton Duarte do; Oliveira, Solange Maria de; Melo, Maria Celeste Nunes de; Fernandes, Maria José de Britto Costa

doi:10.1590/s0037-86822009000200017

Cited by 6 publications

(2 citation statements)

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“…However, slightly over 30% of the wounds colonized by Staphylococcus spp. were colonized by S. aureus , which is higher than the proportion of 18% reported in a study of isolates from blood cultures and secretions of hospitalized patients in a teaching hospital in Natal, the capital city of the state where the present study was conducted [29]. This confirms that regional characteristics of the population and healthcare processes influence the microbial profiles of hospitals.…”

Section: Discussionsupporting

confidence: 66%

Prevalence and factors associated with wound colonization by Staphylococcus spp. and Staphylococcus aureusin hospitalized patients in inland northeastern Brazil: a cross-sectional study

et al. 2014

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BackgroundInfections by Staphylococcus spp. are often associated with wounds, especially in hospitalized patients. Wounds may be the source of bacteria causing cross-contamination, and are a risk factor for methicillin-resistant Staphylococcus aureus (MRSA) infection. The aim of this study was to investigate the prevalence of wound colonization by Staphylococcus spp., especially S. aureus and MRSA, in hospitalized patients, and to identify the factors associated with such colonization.MethodsThis cross-sectional study enrolled patients with wounds who were hospitalized in a remote and underdeveloped inland region of northeastern Brazil with extreme poverty. Samples were collected using sterile swabs with 0.85% saline solution, and coagulase-negative Staphylococcus spp., S. aureus, and MRSA were identified using standard laboratory procedures. Data regarding the sociodemographic characteristics, antibiotic use, and comorbidities of the patients were collected using the medical records and a questionnaire.ResultsA total of 125 wounds were analyzed. The patients had a mean age of 63.88 years and a mean 3.84 years of school education. Eighty-one wounds (64.80%) were colonized by Staphylococcus spp. Twenty-five wounds (20%) were colonized by S. aureus, 32% of which were colonized by MRSA. Wound colonization by Staphylococcus spp. was associated with pneumonia or other respiratory disease (p = 0.03). Wound colonization by S. aureus was associated with nasal colonization by S. aureus (p < 0.001), fewer days of prior antibiotic use (p = 0.04), admission to a medical ward (p = 0.02), and age >65 years (p = 0.05). Among patients with wound colonization by MRSA, 37.50% had a history of prior antibiotic use, 75% had two or more comorbidities, 25% had cancer or diabetes, 50% had cardiovascular disease, and 50% died.ConclusionsWounds can be the source of Staphylococcus spp. infection, and high proportions of wounds are colonized by S. aureus and MRSA. Nasal colonization by S. aureus may be a source for wound colonization by S. aureus, illustrating the importance of preventing cross-contamination in hospital environments, especially among elderly patients. Wounds should be carefully managed to prevent microbial spread, thereby assisting patient recovery and reducing healthcare costs.

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Section: Discussionsupporting

confidence: 66%

Prevalence and factors associated with wound colonization by Staphylococcus spp. and Staphylococcus aureusin hospitalized patients in inland northeastern Brazil: a cross-sectional study

et al. 2014

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“…In Brazil, oxacillin is used instead of methicillin; the two drugs are similar and exhibit the same mechanism of bacterial resistance. 10…”

Section: Introductionmentioning

confidence: 99%

Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines

et al. 2017

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The History of Methicillin-Resistant Staphylococcus aureus in Brazil

Andrade

Luiz

Souza

et al. 2020

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Since the emergence of MRSA in the 1960s, a gradual increase in infections by resistant bacteria has been observed. Clinical manifestations may vary from brand to critical condition due to host risk factors, as well as pathogen virulence and resistance. The high adaptability and pathogenic profile of MRSA clones contributed to its spread in hospital and community settings. In Brazil, the first MRSA isolates were reported in the late 1980s, and since then different genetic profiles, such as the Brazilian epidemic clone (BEC) and other clones considered a pandemic, became endemic in the Brazilian population. Additionally, Brazil’s MRSA clones were shown to be able to transfer genes involved in multidrug resistance and enhanced pathogenic properties. These events contributed to the rise of highly resistant and pathogenic MRSA. In this review, we present the main events which compose the history of MRSA in Brazil, including numbers and locations of isolation, as well as types of staphylococcal cassette chromosome mec (SCCmec) found in the Brazilian territory.

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Prevalência de Staphylococcus spp resistentes à meticilina isolados em uma maternidade escola da Cidade de Natal, Estado do Rio Grande do Norte

Cited by 6 publications

References 20 publications

Prevalence and factors associated with wound colonization by Staphylococcus spp. and Staphylococcus aureusin hospitalized patients in inland northeastern Brazil: a cross-sectional study

Prevalence and factors associated with wound colonization by Staphylococcus spp. and Staphylococcus aureusin hospitalized patients in inland northeastern Brazil: a cross-sectional study

Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines

The History of Methicillin-Resistant Staphylococcus aureus in Brazil

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