Action of antibiotic oxacillin on in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) previously treated with homeopathic medicines

Abstract

Cultures of MRSA treated with Belladonna or MRSA nosode exhibited reduced growth in vitro, reduced enzymatic activity and became more vulnerable to the action of the antibiotic oxacillin. Further studies are needed on the biomolecular basis of these effects.

Effect of Homeopathic Medicines and a Nosode on Larvae of Cochliomyia hominivorax (Diptera: Calliphoridae)

“…12 The in-vitro effect of homeopathy on living cells is scientifically consolidated by several renowned studies and without requiring animal models. 13 These effects have already been reported for bacteria, 12,14 protozoa, 15,16 fungi, 17 cell cultures, 18,19 and reproductive cells of mammals. 20 Recently, effects of homeopathic medicines have been demonstrated on the bacterium Streptococcus pyogenes.…”

“…These potencies were chosen to approximate studies involving homeopathic preparations and in-vitro tests found in the relevant scientific literature. 12,14 The homeopathic medicines Sulfur 12cH and Pyrogenium 12cH were produced according to the Hahnemann centesimal method: 100 manual succussions were performed between each Hahnemann dilution until potency 12cH was reached, following the instructions in the third edition of the Brazilian Homeopathic Pharmacopoeia. 9 The medicine Sulfur was chosen for its general, positive, and persistent action on the skin.…”

In Vitro Effects of Homeopathic Drugs on Cultured Escherichia coli

“…13 In addition, the authors demonstrated that treatment of MRSA cultures with Belladonna or MRSA nosode (6cH and 30cH) reduced bacterial growth in vitro, decreased enzymatic activity, and increased bacterial susceptibility to antibiotic treatment. 12 Nambison et al also found significant effects of high potencies of homeopathic drugs on bacterial cultures in vitro. 11 Several mechanisms may aid in explaining the different results derived from our study.…”

“…10,11 In addition, significant in vitro effects of homeopathic drugs on bacterial strains were demonstrated, pointing to a direct action of these remedies on the bacteria. 12,13 These studies were performed with strains of methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two types of bacteria rarely causing UTIs. A direct treatment effect of homeopathic drugs on bacteria in vitro is not in accordance with the general principles of homeopathy.…”

>b<>i<Locus Minoris Resistentiae>/i< e sua abordagem homeopática na prática clínica de animais de companhia>/b<

“…O Mercado Europeu e o Japão são duas potências econômicas ávidas por consumir carne bovina orgânica e leite sem resíduos de agrotóxicos e ou antimicrobianos(ARENALES, 2002), já que a administração indiscriminada e inadequada destes medicamentos os torna potencialmente tóxicos aos animais e aos consumidores finais. Alem disso, contribuem para o surgimento e disseminação de resistência antimicrobiana, não apenas comprometendo o sucesso terapêutico do animal, mas também envolvendo disseminação de fatores de resistência no meio ambiente(LEES et al, 2017), o que constitui um risco para a saúde pública(PASSETI et al, 2017). Assim, o uso de homeopatia apresenta vantagens tais como: não gera resíduos ambientais ou nos produtos de origem animal; não gera resistência; tem baixa toxicidade; são de fácil administração; e é uma terapia de baixo custo(FORTUOSO et al, 2019).Por outra parte, os medicamentos homeopáticos atuam na promoção do aumento da capacidade de resposta do hospedeiro e, além disso, é uma forma de tratamento permitida e recomendada nas legislações de produção animal orgânica (MARCO; BISON, 2009), com excelentes resultados práticos (ARENALES, 2002), sendo utilizada para tratar uma infinidade de condições clínicas (CRACKNELL; MILLS, 2011).…”