Impacto do laser de baixa intensidade na supressão de infecções pelos vírus Herpes simplex 1 e 2: estudo in vitro

Abstract

The use of low-level laser to suppress infections caused by Herpes simplex viruses 1 and 2 was evaluated after one to five applications. A gradual reduction in replication of Herpes simplex viruses 1 and 2 was observed, with 68.4% and 57.3% inhibition, respectively, after five applications, thus favoring its clinical use.

Recurrent herpes simplex infections: laser therapy as a potential tool for long-term successful treatment

“…However, its efficacy in long-term suppression of herpes simplex infections has yet to be established. In vitro and in vivo studies have been conducted 7,8 and positive outcomes have been shown to be directly related to the number of treatment sessions and the virus type.…”

“…LLLT treatment sessions were performed in accordance with the in vitro study previously reported by Ferreira et al and with the regimen described by the manufacturer. The two cases studied indicate the need for longitudinal studies, in order to establish LLLT treatment protocols for infectious agents and other related microorganisms and for a range of immunosuppressed patients, for whom a generally accepted treatment course has yet to be descriebd 7 .…”

“…The analysis performed was focused on aspects that could be generalized for the treatment course of a wide range of ulcerative lesions of the oral cavity: location; underlying conditions or associated infections or coinfections; impact on the quality of life; functional discomfort; skin trauma; and that feasibility of a clinical evaluation of the patient's partner 7,8 . Currently, no definitive therapy has been described for HSV infections; however, medications and laser therapy (LLLT) could reduce the severity and recurrence of lesions.…”

“…For patient 2, who had more extensive and painful ulcerations, LLLT was suggested, since its biostimulating properties promptly reduce discomfort and pain, while simultaneously accelerating tissue reparation. Morevoer, LLLT preserves the tissues and can be repeatedly used without posing a serious risks to the patient, as shown by in vitro studies, where cells were maintained 100% viable when the same protocol was used 7,8 . The management of herpetic infection is indeed challenging, since none of the different methods of treatment guarantees full remission 9 .…”

Tratamento da neuralgia pós-herpética com irradiações a laser de baixa intensidade: revisão da literatura

“…O LBI tem sido bastante empregado na prática clínica de diversas áreas da saúde, devido aos seus efeitos anti-inflamatório, analgésico, antiedematoso e de contribuição para o reparo tecidual. Entre os efeitos citados pode-se incluir também a degranulação de mastócitos, o aumento da circulação periférica, a vasodilatação e a proliferação fibroblástica [5]. Muitas pesquisas, in vitro e in vivo, vêm sendo realizadas sobre LBI e seu uso terapêutico.…”