Síndrome cardiopulmonar por hantavírus no Triângulo Mineiro e Alto Paranaíba, Minas Gerais, 1998-2005: aspectos clínico-epidemiológicos de 23 casos

Abstract

RESUMO Foram analisados os achados epidemiológicos, clínicos, laboratoriais e terapêuticos de 23 casos de síndrome cardiopulmonar por hantavírus, identificados sorologicamente ou por imunohistoquímica em hospitais do município de Uberlândia, Minas Gerais. Febre (100%), dispnéia (100%) e mialgias (78%) foram os sintomas mais frequentemente observados nesta casuística. Os sinais físicos mais prevalentes foram hipotensão (65%) e taquicardia (65%). Achados laboratoriais mais comuns incluíram trombocitopenia (96%), hemoconcentração (83%) e leucocitose (74%). Valores anormais de enzimas hepáticas foram encontrados em todos os pacientes testados e alterações em radiografias de ABSTRACT The epidemiological, clinical, laboratory and treatment findings from 23 cases of hantavirus cardiopulmonary syndrome were analyzed. These cases were identified either serologically or immunohistochemically in hospitals in the municipality of Uberlândia, State of Minas Gerais. Fever (100%), dyspnea (100%) and myalgia (78%) were the symptoms most frequently observed in this sample. The most prevalent physical signs were hypotension (65%) and tachycardia (65%). The most common laboratory findings included thrombocytopenia (96%), hemoconcentration (83%) and leukocytosis (74%

Prevalence of antibody to hantaviruses in humans and rodents in the Caribbean region of Colombia determined using Araraquara and Maciel virus antigens

“…However, none of the antibody-positive individuals reported any symptoms suggestive of HPS (Jonsson et al 2010), indicating that the infections were mild or asymptomatic, as previously reported in Colombia and Brazil (Limongi et al 2007, Londoño et al 2011.…”

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

“…In this region, HPCS is caused by ARAV, which has been cited by Figueiredo et al 2 as probably the most virulent hantavirus in the Americas. It is possible that in many of our patients, HPCS was only suspected when they became severely ill, and this negatively affected their survival 2,38 . However, delays in treating HPCS have also been found to occur in other Brazilian regions, with HPCS case fatality rates caused by other hantaviruses that ranged from 44% in the state of Mato Grosso to 26% in the state of Santa Catarina 18,39 .…”

Síndrome pulmonar e cardiovascular por hantavírus: aspectos clínicos de uma doença emergente no sudeste brasileiro

“…Esta observação mostra a restrição hídrica como uma importante medida terapêutica no tratamento dos pacientes com SPCVH, uma síndrome de extravasamento capilar em que os grandes volumes infundidos terminam no interstício pulmonar agravando a insuficiência respiratória 1 Entretanto, alguns autores recomendam a infusão hídrica visando a aumentar o débito cardíaco e a perfusão tecidual. Porém, num estudo com 23 pacientes, realizado, na região do triângulo mineiro, os autores não encontraram relação entre sobrevida e infusão hídrica 16 .…”