Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Figueiredo, Glauciane Garcia de; Borges, Alessandra Abel; Campos, Geraldo Maia; Machado, Alex Martins; Saggioro, Fabiano Pinto; Júnior, Gilberto dos Santos Sabino; Badra, Soraya Jabur; Ortiz, Alberto Anastacio Amarilla; Figueiredo, Luíz Tadeu Moraes

doi:10.1590/s0037-86822010000400002

Cited by 23 publications

(17 citation statements)

References 23 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This fatality ratio is lower than others reported in previous studies in the region of Ribeirão Preto, which was approximately 50% (Campos et al 2009, Figueiredo et al 2009bFigueiredo et al 2010. ARAV, the causative of HCPS in the region of Ribeirão Preto is, probably, the most virulent among all Brazilian hantaviruses (Figueiredo et al 2009b).…”

Section: Discussioncontrasting

confidence: 59%

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Figueiredo¹,

Pádua²,

Júnior³

et al. 2011

VR&R

Self Cite

View full text Add to dashboard Cite

Cardiopulmonary Syndrome (HCPS) is a severe disease caused by Hantaviruses. In the present study, we have analyzed sera of 62 HCPS suspected cases from the region of Ribeirão Preto, São Paulo, in the period of 2010-2011. Clinical samples of twelve patients were positive, based on both RT-PCR and IgM-ELISA. Hantavirus-infected patients included 8 males and 4 females, 16-57 years old, 3 of whom were rural workers (25%) and one of them related direct contact with wild rodents. The majority of the other patients (75%) lived in the periphery of cities and reported the presence of rodents in their homes. The case fatality ratio of these 12 HCPS cases was 41.6%. Our results confirm that hantaviruses are endemic, with occurrence of HCPS and fatalities, every year, in the region of Ribeirão Preto. More educational and preventive measures are necessary in order to prevent human infections by hantavirus in the region, and other parts of Brazil.

show abstract

“…The levels of IgG are detectable throughout the life of the individual, allowing studies about the prevalence of HPS [36]. Diagnosis can also be done by PCR techniques, already performed in research centers in Brazil, but routine use of this technique is limited due to its costs [37,38].…”

Section: Diagnosismentioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

show abstract

“…Between 1993-2010, more than 1,300 cases of HPCS have been reported in all the Brazilian regions, distributed throughout 14 states (MS/ SVS/DVE 2010). Five hantaviruses have been reported to cause hantavirus pulmonary and cardiovascular syndrome (HPCS) in Brazilian patients: Anajatuba, Araraquara, Castelo dos Sonhos, Juquitiba and Laguna Negra-like (Figueiredo et al 2010). Hantavirus infection in Brazil is predominantly related to agricultural activity and a common manner of contracting this infection, especially in remote small towns, is through the cleaning of rural grain storage buildings.…”

mentioning

confidence: 99%

Serological evidence of hantavirus infection in rural and urban regions in the state of Amazonas, Brazil

Gimaque

Bastos

Braga

et al. 2012

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

“…Alternatively, it is possible that the animals, after a long period of infection, could maintain a low viral load, not allowing detection of the agent by RT-PCR (Moreli et al 2004;Schönrich et al 2008;Easterbrook et al 2008). The phylogenetic analysis showed that the Hantavirus infecting one of the captured N. lasiurus was the ARAV, which is the most common cause of HCPS in the Ribeirão Preto region Figueiredo et al 2010). This is worrying, because this Hantavirus, based on case-fatality ratio, is probably the most virulent among all Hantaviruses worldwide ).…”

Section: Discussionmentioning

confidence: 99%

“…In the southeast and central plateau of Brazil, the Juquitiba virus is associated with the Oligoryzomys nigripes rodent and the Araraquara virus with Necromys lasiurus (Suzuki et al 2004;Figueiredo et al 2009). N. lasiurus lives in the Cerrado areas of the central plateau and southeastern Brazil, which includes the city of Ribeirão Preto Figueiredo et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Araraquara Hantavirus in Necromys Lasiurus Captured on the Campus of the Universidade De São Paulo in Ribeirão Preto, Sp, Brazil

Machado¹,

Souza²,

Machado³

et al. 2011

VR&R

View full text Add to dashboard Cite

Hantavirus is a genus including dozens of genotypes in the Bunyaviridae family. Human infection by Hantavirus occurs mainly from inhalation of aerosols from the droppings of infected wild rodents. American Hantaviruses produce a severe cardiopulmonary syndrome with a high fatality rate. The objective of this study was to identify rodents infected with Hantavirus on the campus of the Universidade de São Paulo in the municipality of Ribeirão Preto. A routine rodent trapping with 45 Sherman traps was performed; 15 rodents were captured and identified, using classic taxonomic classification. About 2/3 of the captured rodents were Necromys lasiurus. Three blood samples of N. lasiurus were IgG positive to Hantavirus in ELISA. The Hantavirus partial S and M gene sequences were recovered from the blood of one N. lasiurus and the phylogenetic analysis of nucleotide sequences showed that this rodent was infected with Araraquara Hantavirus. The presence of N. lasiurus infected with Hantavirus on the campus of the Universidade de São Paulo is a frightening problem. Measures for prevention of human infections by Hantavirus should be implemented on the campus, based on: reducing rodent shelter and food sources in and around buildings, standard sanitary precautions while rodent-contaminated areas are being cleaned up, and preventive measures, such as biosafety masks, for persons who have occupational exposure to wild rodents.

show abstract

Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil

Cited by 23 publications

References 23 publications

Hantavirus Cardiopulmonary Syndrome in Ribeirão Preto, Brazil, 2010-2011

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Serological evidence of hantavirus infection in rural and urban regions in the state of Amazonas, Brazil

Araraquara Hantavirus in Necromys Lasiurus Captured on the Campus of the Universidade De São Paulo in Ribeirão Preto, Sp, Brazil

Contact Info

Product

Resources

About