Introduction: Emergent and re-emergent waterborne protozoans have become a worldwide public health problem, especially among vulnerable groups. Methods: This cross-sectional study evaluated 17 HIV-infected children and their families. Results: A high (76.5%) percentage of parasite-infected children was observed, even among children with CD4 + T-cell counts of >200 cells/mm 3 . Giardia spp., Cryptosporidium spp. and Cyclospora spp. were observed in 41.2% of these children. Low income, poor hygiene practices, and co-infection in domestic, peridomestic and scholastic environments were signifi cant sources of these intestinal infections. Conclusions: Early diagnosis, timely treatment, and socio-educational interventions may improve the health conditions of this vulnerable population.