Eliminação da transmissão da doença de Chagas pelo Triatoma infestans no Brasil: um fato histórico

Ferreira, Israel de Lucena Martins; Silva, Tiago Pessoa Tabosa e

doi:10.1590/s0037-86822006000500018

Cited by 37 publications

(27 citation statements)

References 6 publications

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“…7,22 Our epidemiological data and T cruzi eradication campaigns over the last 20 years in Brazil suggest that infection occurred in most subjects during childhood or young adulthood. 23 Thus, the lack of an age association suggests that variation in host genetics or immunology, rather than duration of infection, is more important in determining disease risk.…”

Section: Discussionmentioning

confidence: 99%

Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi –Seropositive Former Blood Donors

et al. 2013

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Background Very few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi–infected persons. Methods and Results We performed a retrospective cohort study among initially healthy blood donors with an index T cruzi–seropositive donation and age-, sex-, and period-matched seronegatives in 1996 to 2002 in the Brazilian cities of São Paulo and Montes Claros. In 2008 to 2010, all subjects underwent medical history, physical examination, ECGs, and echocardiograms. ECG and echocardiogram results were classified by blinded core laboratories, and records with abnormal results were reviewed by a blinded panel of 3 cardiologists who adjudicated the outcome of Chagas cardiomyopathy. Associations with Chagas cardiomyopathy were tested with multivariate logistic regression. Mean follow-up time between index donation and outcome assessment was 10.5 years for the seropositives and 11.1 years for the seronegatives. Among 499 T cruzi seropositives, 120 (24%) had definite Chagas cardiomyopathy, and among 488 T cruzi seronegatives, 24 (5%) had cardiomyopathy, for an incidence difference of 1.85 per 100 person-years attributable to T cruzi infection. Of the 120 seropositives classified as having Chagas cardiomyopathy, only 31 (26%) presented with ejection fraction <50%, and only 11 (9%) were classified as New York Heart Association class II or higher. Chagas cardiomyopathy was associated (P<0.01) with male sex, a history of abnormal ECG, and the presence of an S3 heart sound. Conclusions There is a substantial annual incidence of Chagas cardiomyopathy among initially asymptomatic T cruzi–seropositive blood donors, although disease was mild at diagnosis.

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Section: Discussionmentioning

confidence: 99%

Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi –Seropositive Former Blood Donors

et al. 2013

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“…Chemical control campaigns against Chagas disease vectors have considerably reduced its prevalence in recent decades by eliminating populations of the most common vector species in human habitats. Vector transmission by Triatoma infestans , a non native vector introduced from Bolivia, has been officially interrupted in Brazil [2] and the same achievement has been obtained for Rhodnius prolixus in parts of the Andean Pact and Central America [3,4]. But, there were some endemic states in Brazilian Northeastern where T .…”

Section: Introductionmentioning

confidence: 99%

Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis

et al. 2016

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BackgroundIn Latin America, the bloodsucking bugs Triatominae are vectors of Trypanosoma cruzi, the parasite that causes Chagas disease. Chemical elimination programs have been launched to control Chagas disease vectors. However, the disease persists because native vectors from sylvatic habitats are able to (re)colonize houses—a process called domiciliation. Triatoma brasiliensis is one example. Because the chemosensory system allows insects to interact with their environment and plays a key role in insect adaption, we conducted a descriptive and comparative study of the chemosensory transcriptome of T. brasiliensis samples from different ecotopes.Methodology/Principal FindingIn a reference transcriptome built using de novo assembly, we found transcripts encoding 27 odorant-binding proteins (OBPs), 17 chemosensory proteins (CSPs), 3 odorant receptors (ORs), 5 transient receptor potential channel (TRPs), 1 sensory neuron membrane protein (SNMPs), 25 takeout proteins, 72 cytochrome P450s, 5 gluthatione S-transferases, and 49 cuticular proteins. Using protein phylogenies, we showed that most of the OBPs and CSPs for T. brasiliensis had well supported orthologs in the kissing bug Rhodnius prolixus. We also showed a higher number of these genes within the bloodsucking bugs and more generally within all Hemipterans compared to the other species in the super-order Paraneoptera. Using both DESeq2 and EdgeR software, we performed differential expression analyses between samples of T. brasiliensis, taking into account their environment (sylvatic, peridomiciliary and domiciliary) and sex. We also searched clusters of co-expressed contigs using HTSCluster. Among differentially expressed (DE) contigs, most were under-expressed in the chemosensory organs of the domiciliary bugs compared to the other samples and in females compared to males. We clearly identified DE genes that play a role in the chemosensory system.Conclusion/SignificanceChemosensory genes could be good candidates for genes that contribute to adaptation or plastic rearrangement to an anthropogenic system. The domiciliary environment probably includes less diversity of xenobiotics and probably has more stable abiotic parameters than do sylvatic and peridomiciliary environments. This could explain why both detoxification and cuticle protein genes are less expressed in domiciliary bugs. Understanding the molecular basis for how vectors adapt to human dwellings may reveal new tools to control disease vectors; for example, by disrupting chemical communication.

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“…T. vitticeps is a wild and endemic species of the Atlantic Forest that is responsible for sporadic cases of human Chagas disease in that region [27–30], and T. infestans is considered the most important domiciliated T. cruzi vector that was previously widely distributed in South America [31, 32]. …”

Section: Resultsmentioning

confidence: 99%

First Report ofAprostocetus asthenogmus(Hymenoptera: Eulophidae) in South America and Parasitizing Eggs of Triatominae Vectors of Chagas Disease

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et al. 2014

Journal of Parasitology Research

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We report for the first time the parasitism of eggs of two triatomine Chagas disease vectors, Triatoma infestans and T. vitticeps, by the microhymenopterous parasitoid Aprostocetus asthenogmus. We also describe the first identification of this parasitoid in South America. A. asthenogmus were captured near unparasitized triatomine colonies in the municipality of Vitória, state of Espírito Santo, Brazil, and placed into pots with recently laid triatomine eggs. After 24 days, we observed wasps emerging from T. infestans and T. vitticeps eggs. Several characteristics of this parasitoid species suggest that it could be a potential biological control agent of triatomine species.

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Eliminação da transmissão da doença de Chagas pelo Triatoma infestans no Brasil: um fato histórico

Cited by 37 publications

References 6 publications

Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi –Seropositive Former Blood Donors

Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi –Seropositive Former Blood Donors

Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis

First Report ofAprostocetus asthenogmus(Hymenoptera: Eulophidae) in South America and Parasitizing Eggs of Triatominae Vectors of Chagas Disease

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