Preliminary assessment of medicinal plants used as antimalarials in the southeastern Venezuelan Amazon

Caraballo, Alejandro; Caraballo, Brigida; Rodrı́guez-Acosta, Alexis

doi:10.1590/s0037-86822004000200016

Cited by 41 publications

(26 citation statements)

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“…Also, two ellagitannins with antiviral properties were earlier isolated by Corthout et al (1991). Onwuka, 1992;Abo et al, 1999;Apori, 1998;Ayoka et al, 2006 4 Limonoids, Naphthoquinones Not tested Caraballo et al, 2004 They are geraniin and galloygeraniin. Spondias mombin has high extractable phenolic and tannin content (Apori, 1998).…”

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

“…Spondias mombin has high extractable phenolic and tannin content (Apori, 1998). The anti-malarial activity of Spondias mombin may be linked to a range of compounds like anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids (Caraballo et al, 2004). Abo et al (1999) reported that Spondias mombin contains tannins, saponins and anthraquinone glycosides that showed significant antimicrobial activity without any significant antifungal activity.…”

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

“…Most of the effects observed with extract of Spondias mombin may be attributed to the constituent compounds of phenols, tannins, anthraquinones and flavonoids presence in the plant (Ayoka, 2004;Ayoka et al, 2005 andAkubue et al, 1983;Caraballo et al, 2004;Corthout et al, 1994). The presence of these active compounds has been reported for several activities like antibacterial (Corthout et al, 1994;Ajao et al, 1985), anti-inflammation (Abad et al, 1996), haemostatic activity (Kone-Bamba et al, 1987), anti-microbial (Corthout et al, 1994;Abo et al, 1999;Verpoorte and Dihal, 1987), antioxidant (Castner et al, 1998;Shaltes and Raffauf, 1990), abortifacients (Akubue et al, 1983;Offiah and Anyanwu, 1989), purgatives (Akubue et al, 1983), hypnotics (Akubue et al, 1983;Ayoka et al, 2005), anti-diarrhoea (Akubue et al, 1983), anti-helmintic (Ademola et al, 2005), anti-malarial (Carabalo et al, 2004), wound-healing (Villegas et al, 1997;Ajao et al, 1985), enzyme inhibitor (Coates et al, 1994), increased capillary permeability in rats (Villegas et al, 1997), anti-free radical action, anti-aging, reduced glutathione synthesis (Pauly and Fleury, 2002).…”

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

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Medicinal and economic value of spondias mombin

Ayoka¹,

Akomolafe²,

.³

et al. 2010

African Journal of Biomedical Research

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This article reviewed the folk medical value of Spondias mombin with the correlated research findings on the uses of Spondias mombin. Most of the folk uses had been scientifically proven in most of the regions where those beliefs are based. The plant was described with habitat, the local uses including the uses of its parts mentioned. We reviewed the ethnomedicinal uses, the biological activities and the phytochemistry of Spondias mombin.

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Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

Section: Phytochemistry Of Spondias Mombinmentioning

confidence: 99%

See 1 more Smart Citation

Medicinal and economic value of spondias mombin

Ayoka¹,

Akomolafe²,

.³

et al. 2010

African Journal of Biomedical Research

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“…The leaf extract of the plant has been strongly advocated for use in speedy woundhealing processes, hemorrhoids, and inflamed mucous membrane due to its tannin content (Njoku & Akumefula, 2007). Its pharmacological potencies such as antioxidative, antimicrobial, antimalarial, and antibacterial have also been documented (Abo et al, 1999;Caraballo et al, 2004;Corthout et al, 1994;Villegas et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

Sabiu

Garuba

Sunmonu

et al. 2015

Pharmaceutical Biology

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Context: Spondias mombin Linn (Anacardiaceae) and Ficus exasperata Valh (Moraceae) are botanicals with known phytotherapeutic potentials in the traditional system of medicine in the world. Objective: The objective of this study is to investigate the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Materials and methods: Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight (b.w.)). Ulcerated rats were orally administered with esomeprazole (a reference drug) at a dose of 20 mg/kg body weight, and Spondias mombin and Ficus exasperata at a dose of 100 and 200 mg/kg b.w. once daily for 21 d after ulcer induction. Gastric secretions and antioxidant parameters were thereafter evaluated. Results: The significantly increased (p50.05) ulcer index, gastric volume, malondialdehyde level, and pepsin activity by indomethacin were effectively reduced by 65.40, 36.47, 45.71, and 53.79%, respectively, following treatment with F. exasperata at 200 mg/kg b.w. S. mombin at this regimen also attenuated these parameters by 71.70, 46.62, 50.16, and 55.73%. Moreover, the extracts significantly increase the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. Discussion and conclusion: These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.

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“…In another study, the anacardis acid derivative from the hexane extract of the plant was showed to possess beta lactamase inhibitory properties 7 . The anti-malarial activity of Spondias mombin discovered lately is said to have been linked to a range of compounds like anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids present in the leaves 8 . The leaf extract has also shown anti-inflammatory activity in animal studies 9 .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

Bhandarkar¹,

Bhat²,

Vinodraj³

et al. 2015

Int. Res. J. Pharm.

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Spondias mombin is valued ethno medically in folkloric medicine. This medicinal plant according to traditional claim is said to cure various infectious and inflammatory ailments of gastrointestinal and genitourinary tract. Formation of reactive oxygen species (ROS) in inflammatory conditions is said to result in oxidative stress. The antibacterial and anti-inflammatory properties of Spondias mombin especially its leaves, have been linked to a range of compounds in it viz., anthraquinones, berberine, flavonoids, naphthoquinones, sesquiterpenes, quassiniods, indole and quinoline alkaloids. Hence, we aimed at exploring the antioxidant potential of the leaf extract of Spondias mombin by in vitro methods. The ethanolic extract of leaves was subjected to spectrophotometric analysis and DPPH methods to explore its reducing potential. The total phenolic and total flavonoid content was estimated by colorimetric methods. It was observed that ethanolic extract of Spondias mombin demonstrated a dose-dependent increase in the reducing property, with higher potency than the reference compound sodium metabisulphate. Spondias mombin shade dried leaf powder macerated and later extracted with hot water possessed a significantly high content of flavonoids than those extracted with other solvents. The leaf extract of Spondias mombin possesses significant antioxidant activity that may be attributed to its high flavonoid content which could afford protection in inflammatory conditions. This finding strengthens its widespread use in traditional medicine. Animal studies and clinical trials are necessary to validate these beneficial properties and translate them into clinical utility.

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Preliminary assessment of medicinal plants used as antimalarials in the southeastern Venezuelan Amazon

Cited by 41 publications

References 4 publications

Medicinal and economic value of spondias mombin

Medicinal and economic value of spondias mombin

Indomethacin-induced gastric ulceration in rats: Ameliorative roles ofSpondias mombinandFicus exasperata

In Vitro Evaluation of Antioxidant Activity of Spondias Mombin Leaf Extract: Discovering Future Avenues for an Affordable and Efficient Antioxidant

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