Análise do desempenho da pesquisa de anticorpos IgG anti-formas promastigotas vivas de Leishmania (V.) braziliensis (AAPV-IgG), por citometria de fluxo no diagnóstico da Leishmaniose Tegumentar Americana

In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA‐DR+ neutrophils; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio; ↑HLA‐DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α‐Leishmania IgG and ↑serum + ). Selective changes were observed in L1 (↑%HLA‐DR+ neutrophils, ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑serum + ) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α‐Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well‐known leishmanicidal events (↑CD8+ T cells; ↑serum + and ↑α‐Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA‐DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA‐DR+/CD4+ HLA‐DR+ T cell ratio and ↑ serum + ). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.

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Análise do desempenho da pesquisa de anticorpos IgG anti-formas promastigotas vivas de Leishmania (V.) braziliensis (AAPV-IgG), por citometria de fluxo no diagnóstico da Leishmaniose Tegumentar Americana

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References 13 publications

Specific IgM, IgG and IgG1 directed against Toxoplasma gondii detected by flow cytometry and their potential as serologic tools to support clinical indirect fundoscopic presumed diagnosis of ocular disease

Specific IgM, IgG and IgG1 directed against Toxoplasma gondii detected by flow cytometry and their potential as serologic tools to support clinical indirect fundoscopic presumed diagnosis of ocular disease

Distinct Pattern of Immunophenotypic Features of Innate and Adaptive Immunity as a Putative Signature of Clinical and Laboratorial Status of Patients with Localized Cutaneous Leishmaniasis

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