Impacto do controle químico extensivo de Triatoma infestans sobre a incidência de casos agudos e a prevalência de doença de Chagas: o exemplo de Montalvânia, Minas Gerais

Rassi, Anis; Luquetti, Alejandro O.; Ornelas, José Florisval; Ervilha, José Fernandes; Rassi, Gustavo Gabriel; Azeredo, Bernardino Vaz de Mello; Dias, João Carlos Pinto

doi:10.1590/s0037-86822003000600013

Cited by 7 publications

(3 citation statements)

References 10 publications

(1 reference statement)

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“…A relationship between house infestation (proportion of houses infested) and the number of triatomines/house was fitted to data from various locations prior to vector control and applied to cases where there was only one triatomine species present in the dwellings, as well as to situations with mixtures of species and developmental stages, various types of houses and bug densities per house. These relationships can be improved when data are stratified (if available) with some critical co-variates, such as house-construction materials, number of humans and zoonotic hosts in the dwellings, and IRS status 8, 9 . Understanding further these relationships taking into account other variables (such as the distribution of triatomines per house, the triatomine species, the time elapsed after intervention, etc.…”

Section: Insights Gained From Quantitative and Mathematical Modellingmentioning

confidence: 99%

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease

2019

Gates Open Res

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Chagas disease (CD) persists as one of the neglected tropical diseases (NTDs) with a particularly large impact in the Americas. The World Health Organization (WHO) recently proposed goals for CD elimination as a public health problem to be reached by 2030 by means of achieving intradomiciliary transmission interruption (IDTI), blood transfusion and transplant transmission interruption, diagnostic and treatment scaling-up and prevention and control of congenital transmission. The NTD Modelling Consortium has developed mathematical models to study Trypanosoma cruzi transmission dynamics and the potential impact of control measures. Modelling insights have shown that IDTI is feasible in areas with sustained vector control programmes and no presence of native triatomine vector populations. However, IDTI in areas with native vectors it is not feasible in a sustainable manner. Combining vector control with trypanocidal treatment can reduce the timeframes necessary to reach operational thresholds for IDTI (<2% seroprevalence in children aged <5 years), but the most informative age groups for serological monitoring are yet to be identified. Measuring progress towards the 2030 goals will require availability of vector surveillance and seroprevalence data at a fine scale, and a more active surveillance system, as well as a better understanding of the risks of vector re-colonization and disease resurgence after vector control cessation. Also, achieving scaling-up in terms of access to treatment to the expected levels (75%) will require a substantial increase in screening asymptomatic populations, which is anticipated to become very costly as CD prevalence decreases. Further modelling work includes refining and extending mathematical models (including transmission dynamics and statistical frameworks) to predict transmission at a sub-national scale, and developing quantitative tools to inform IDTI certification, post-certification and re-certification protocols. Potential perverse incentives associated with operational thresholds are discussed. These modelling insights aim to inform discussions on the goals and treatment guidelines for CD.

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Section: Insights Gained From Quantitative and Mathematical Modellingmentioning

confidence: 99%

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease

2019

Gates Open Res

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“…In 2006, Brazil was certified by the Pan American Health Organization/ World Health Organization as having succeeded in stopping the transmission of Chagas disease by its main vector, Triatoma infestans (Klug, 1834). T. infestans is an introduced vector and, as such, exhibits virtually no significant stocks in the sylvatic environment, making it vulnerable to targeted reduction, as achieved through PCDCh actions 3,4 with insecticides.…”

Section: Introductionmentioning

confidence: 99%

Entomological survey in the state of Piauí, Northeastern Brazil, reveals intradomiciliary colonization of Triatoma brasiliensis macromelasoma

Santos

Sousa

Santos

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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This survey aimed to assess the presence of triatomine vectors of Chagas disease within the rural communities of São João do Piauí, Northeast Brazil. Intradomiciliary and peridomiciliary collection strategies were implemented wherein 279 specimens of Triatoma brasiliensis macromelasoma, both nymph and adult were found in 15 (50%) of the studied homes. Of the intradomiciliary insects, 73 (67.6%) were identified as nymph instars (1st instar [N1]= 6, N2= 14, N3= 28, N4= 7 and N5= 18). In the studied communities, a continuous interaction between triatomine bugs and humans could be shown. It is therefore urgent that suitable strategies for the control of the triatomine vector are implemented in this area.

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“…Perante esse panorama, novos alvos para uma quimioterapia específica estão sendo analisados. Uma compreensão maior das vias da biosíntese de novo de esteróis, proteólise mediada por cruzipaína, metabolismo de pirofosfato, sínteses de tripanotiona, via da diidrofolato redutase, biosíntese de fosfolipídeo e prenilação e acilação de proteínas poderão eventualmente contribuir á busca de novas alternativas terapêuticas (Rassi et al, 2003;Urbina e Docampo, 2003).…”

Section: 11quimioterapia Contra a Doença Chagasunclassified

Análise do transporte de glutamato e GABA em epimastigotas de Trypanosoma cruzi.

Rojas¹

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Em português, permeases de aminoácidos/auxina FCCP Trifluorometoxfenil-carbonil hidrazona GABA Àcido gamma-aminobutírico GAD Glutamato decarboxilase GS Glutamina sintetase GABA-T GABA transaminase NMDA N-metil-D-aspartato PAG Glutaminase dependente de fosfato SNC Sistema Nervoso Central SSDAH Succinil semialdeido desidrogenase ORFs Fase aberta de leitura TCA Ácido tricloroacético PBS Buffer fosfato salino μCi micro Curie ATP Adenosina Trifosfato cpm Contas por minuto

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Impacto do controle químico extensivo de Triatoma infestans sobre a incidência de casos agudos e a prevalência de doença de Chagas: o exemplo de Montalvânia, Minas Gerais

Cited by 7 publications

References 10 publications

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease

Insights from quantitative and mathematical modelling on the proposed WHO 2030 goals for Chagas disease

Entomological survey in the state of Piauí, Northeastern Brazil, reveals intradomiciliary colonization of Triatoma brasiliensis macromelasoma

Análise do transporte de glutamato e GABA em epimastigotas de Trypanosoma cruzi.

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