Gastric strongyloidiasis and infection by the human T cell lymphotropic virus type 1 (HTLV-1)

Lambertucci, José Roberto; Leão, Flávia Costa Carvalho; Barbosa, Alfredo José Afonso

doi:10.1590/s0037-86822003000400021

Cited by 12 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HTLV-1 infection is a well known risk factor (sometimes in association with related haematological malignancies), of which we found 24/244 (10%) reports ([214,158,120,159,53,54,143,122,12,111,32,216,77,126,163,114,80,35,164,175,155,116]). Ten of the 24 patients (42%) died.…”

Section: Resultsmentioning

confidence: 59%

Severe strongyloidiasis: a systematic review of case reports

et al. 2013

View full text Add to dashboard Cite

BackgroundStrongyloidiasis is commonly a clinically unapparent, chronic infection, but immuno suppressed subjects can develop fatal disease. We carried out a review of literature on hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), in order to describe the most challenging aspects of severe strongyloidiasis.MethodsWe conducted a structured search using PubMed to collect case reports and short case series on HS/DS published from 1991 to 2011. We restricted search to papers in English, Spanish, Italian and French. Case reports were classified as HS/DS according to given definitions.ResultsRecords screened were 821, and 311 were excluded through titles and abstract evaluation. Of 510 full-text articles assessed for eligibility, 213 were included in qualitative analysis. As some of them were short case series, eventually the number of cases analyzed was 244.Steroids represented the main trigger predisposing to HS and DS (67% cases): they were mostly administered to treat underlying conditions (e.g. lymphomas, rheumatic diseases). However, sometimes steroids were empirically prescribed to treat signs and symptoms caused by unsuspected/unrecognized strongyloidiasis. Diagnosis was obtained by microscopy examination in 100% cases, while serology was done in a few cases (6.5%). Only in 3/29 cases of solid organ/bone marrow transplantation there is mention of pre-transplant serological screening. Therapeutic regimens were different in terms of drugs selection and combination, administration route and duration. Similar fatality rate was observed between patients with DS (68.5%) and HS (60%).ConclusionsProper screening (which must include serology) is mandatory in high - risk patients, for instance candidates to immunosuppressive medications, currently or previously living in endemic countries. In some cases, presumptive treatment might be justified. Ivermectin is the gold standard for treatment, although the optimal dosage is not clearly defined in case of HS/DS.

show abstract

Section: Resultsmentioning

confidence: 59%

Severe strongyloidiasis: a systematic review of case reports

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Alguns pesquisadores relatam a estreita relação entre fatores imunológicos nos pacientes com a infecção pelo HTLV-1 e essa parasitose 31,32 . Esse dado pode estar subestimado, já que neste serviço, não se faz rotineiramente o teste de Baerman-Morais, específico das larvas deste parasita.…”

Section: Discussionunclassified

Mielopatia associada ao HTLV-1: análise clínico-epidemiológica em uma série de casos de 10 anos

Champs

Passos

Barreto

et al. 2010

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introdução: A mielopatia associada ao retrovírus HTLV-1 (HAM/TSP) é uma doença progressiva e incapacitante. O objetivo deste trabalho é determinar características clínico-epidemiológicas de pacientes com HAM/TSP. Métodos: Série de casos admitidos de 01/1998 a 12/ 2007, em hospital de reabilitação utilizando os critérios diagnósticos de HAM/TSP. Resultados: Participaram 206 pacientes, dos quais, 67% eram mulheres, com 53 anos de média de idade, nove anos de média de duração de doença. Os sintomas mais frequentes foram a diminuição da força em membros inferiores, espasticidade, dor, presença de bexiga neurogênica e a constipação intestinal. Os sinais neurológicos foram hiperreflexia, Babinsky, Hoffmann e neuropatia periférica. A presença de dor, de espasticidade muscular e de atrofia medular à ressonância nuclear magnética de medula espinhal foram associadas à duração da doença (p<0,05). Conclusões: A HAM/TSP é uma doença de curso incapacitante e progressiva, em que a dor é relatada precocemente, enquanto a atrofia medular torácica e a espasticidade surgem em fase mais tardia. Existem casos de HAM/TSP com provável transmissão do vírus por via vertical. Palavras-chaves:Epidemiologia. Vírus linfotrófico de células T humana tipo 1. Paraparesia espástica tropical. ABSTRACTIntroduction: Human T cell lymphotropic virus type 1 (HTLV-I) myelopathy (HAM/TSP) is a progressive disabling disorder. This work aimed to analyze clinical features and epidemiology in a sample of HAM/TSP. Methods: All HTLV-1 infected patients with diagnostic criteria for HAM/TSP, consecutively admitted to the Sarah Hospital from 1998 to 2007, were included in the study. Results: 206 patients (67% females; mean age: 53.8 years-old) were diagnosed with HAM/TSP. The mean time of evolution was 9.0 years. The most common neurological symptoms were chronic progressive spastic paraparesis, spasticity, pain, neurogenic bladder and neurogenic bowel. The neurological findings were hyperreflexia, Babinsky, Hoffman and peripheral neuropathy. Pain, spasticity and spinal cord atrophy, observed in MRI, were associated with time of disease (p<0.05). Conclusions: HAM/TSP is a very disabling disorder, in which pain is reported early, while spasticity and thoracic spinal cord atrophy appear in a later phase of the disease. Cases of HAM/TSP exist with a probable vertical viral transmission.

show abstract

“…[2][3][4][5][6]8] It is reported that gastrointestinal involvement is commonly seen in patients with immunodeficiency, but Thompson et al [7] reported two cases that were immunocompetent. [1,7,9] We investigated the immunological status of our patient, after the pathologic examination revealed S. stercoralis, and found that she was not immunocompromised. Further analyses for possible human immunodeficiency virus (HIV) infection were also negative.…”

Section: Case Reportmentioning

confidence: 92%

“…[1,2,7,[9][10][11] Clinically, gastric involvement causes symptoms such as epigastric pain and tenderness, nausea and vomiting. [1,3,6,7] All these also existed in the history of our patient.…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Gastric perforation caused by Strongyloides stercoralis: a case report

Öztürk

Aydınlı²,

Çelebi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

Stronglodiasis, Strongyloides stercoralis'in dişi nematodları tarafından oluşturulan bir parazitozdur. S. stercoralis olguların %50'sinde asemptomatik olan ve mideyi etkileyebilen kronik bir enfeksiyon oluşturur. Mide tutulumu genelde gastriti taklit eden bulgulara neden olur. Biz burada 37 yaşındaki kadın hastada S. stercoralis'e bağlı oluş-tuğunu düşündüğümüz bir mide delinmesi olgusunu sunuyoruz.Anahtar Sözcükler: Strongyloides stercoralis; mide tutulumu; delinme.Strongyloidiasis is a parasitosis caused by the female nematode of the Strongyloides stercoralis. S. stercoralis causes a chronic infection that is asymptomatic in 50% of chronically infected patients, and it can also affect the stomach. Gastric involvement causes symptoms mostly mimicking gastritis. We report herein a case of gastric perforation in a 37-year-old woman, which was thought to be caused by S. stercoralis.

show abstract

Gastric strongyloidiasis and infection by the human T cell lymphotropic virus type 1 (HTLV-1)

Cited by 12 publications

References 0 publications

Severe strongyloidiasis: a systematic review of case reports

Severe strongyloidiasis: a systematic review of case reports

Mielopatia associada ao HTLV-1: análise clínico-epidemiológica em uma série de casos de 10 anos

Gastric perforation caused by Strongyloides stercoralis: a case report

Contact Info

Product

Resources

About