Estudo comparativo da eficácia de isotionato de pentamidina administrada em três doses durante uma semana e de N-metil-glucamina 20mgSbV/kg/dia durante 20 dias para o tratamento da forma cutânea da leishmaniose tegumentar americana

Abstract

ARTIGOEstudo comparativo da eficácia de isotionato de pentamidina administrada em três doses durante uma semana e de N-metil-glucamina 20mgSbV/kg/ dia durante 20 dias para o tratamento da forma cutânea da leishmaniose tegumentar americana A comparative study between the efficacy of pentamidine isothionate given in three doses for one week and N-methil-glucamine in a dose of 20mgSbV/day for 20 days to treat cutaneous leishmaniasis Abstract Seventy-nine patients with cutaneous leishmaniasis were included in this study. The experimental group (n = 38) was treated with pentamidine isothionate in a dose of 4mg/kg/day on alternate days, for one week. The control group (n = 41) was treated with N-methylglucamine in a dose of 20mgSbV/kg/day for 20 days. Twenty-one isolates were identified using monoclonal antibody technique. We characterized Leishmania (Viannia) braziliensis, most frequently. There was a cure rate of 71.05% of the patients in the experimental group and 73.17% in the control group (p = 0.47).We found a statistical significance regarding frequency of ECG alterations between the experimental and control group (p<0.05). In our study pentamidine was as effective as antimonial for the treatment of american cutaneous leishmaniasis. It proved to be a safer drug considering heart toxicity. Moreover, it requires less time to complete the treatment.

Antimony in plasma and skin of patients with cutaneous leishmaniasis – relationship with side effects after treatment with meglumine antimoniate

“…2007). In a previous study conducted in the UHB, patients treated with meglumine antimoniate at the conventional dose also showed arthralgia and myalgia as the main adverse symptoms (Paula et al. 2003).…”

Efficacy of the intralesional treatment with Chenopodium ambrosioides in the murine infection by Leishmania amazonensis

“…Pentavalent antimonials, that were developed more than 50 years ago, are still the first choice among the drugs used in the treatment of leishmaniasis, despite their cardiac and renal toxicity (Paula et al, 2003;Rath et al, 2003). Although there are several drugs on trial for the human leishmaniasis chemotherapy, most of them are new formulations of old drugs.…”

Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

“…A study in Colombia showed a 96% cure of CL in 51 patients who received a total of 4 PI injections of 3 mg kg -1 day -1 (Mitropoulos et al 2010) and a 71% cure was observed in 79 patients in Brazil that received 3 injections of 4 mg kg -1 day -1 (Paula et al 2003). Some authors recommend a single dose of 7 mg kg -1 (Oliveira et al 2011).…”