Esquistossomose na área hiperendêmica de Taquarendi: I Infecção pelo Schistosoma mansoni e formas graves

Bina, José Carlos; Prata, Áluízio

doi:10.1590/s0037-86822003000200003

Cited by 29 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Geographically isolated strains of S. mansoni present significant differences in pathogenicity, which is attributed to greater impairment of organs due to the greater extent and wider distribution of S. mansoni eggs [16], the number of eggs produced by the parasite [7, 17], and the degree of susceptibility of the snail vector [1, 16, 18, 19]. According to Chieffi and Waldman [1], the rarity of hepatosplenic forms in autochthonous cases in São Paulo State (Brazil) may be due to the low rates of snail infection by S. mansoni , which reflects the lower susceptibility of infection of B. tenagophila compared to B. glabrata and B. straminea .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Euzébio

Zuim

Linhares³

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

The pathogenesis of three different Schistosoma mansoni strains from the Brazilian states of Minas Gerais (BH strain) and São Paulo (SJ and SD strains) was evaluated in experimentally infected mice. Observations of the most severe clinical cases among local patients treated (SD strain) in the city of Campinas (São Paulo, Brazil) formed the basis of this study. Mice were used as definitive hosts and were infected with cercariae from Biomphalaria tenagophila (SJ and SD strains) and Biomphalaria glabrata (BH strains). The parameters analyzed were as follows: number of S. mansoni eggs in mice feces; number of granulomas per tissue area in liver, spleen, lungs, pancreas, and ascending colon; measurements of hepatic and intestinal granulomas; number of adult worms; and measurements of trematode eggs. The comparison among the three strains indicated that the SD strain, isolated in Campinas, presented a higher worm recovery relative to the number of penetrating cercariae. In addition, when compared to the SJ and BH strains, the SD strain demonstrated similar pathogenicity to the BH strain, with a greater quantity of granulomas in the viscera, as well as larger granulomas and eggs. Furthermore, a greater quantity of trematode eggs was also shed in the feces.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Bina and Prata [17] have shown an association between the development of the hepatosplenic disease form and the quantity of S. mansoni eggs eliminated in patient stools. The lesions caused by S. mansoni are rarely restricted to one organ, whether it is the liver or intestine.…”

Section: Discussionmentioning

confidence: 99%

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Euzébio

Zuim

Linhares³

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…One could hypothesize that the S. mansoni SJ strain is different because B. tenagophila is the natural intermediate host. Geographical strains of S. mansoni have significant pathogenic differences stemming from the degree of organ impairment, which is dictated by the distribution of S. mansoni eggs [9], the number of eggs produced by the parasite [6, 46], and the degree of susceptibility of the snail vector [9, 10, 18]. …”

Section: Discussionmentioning

confidence: 99%

A Study of the Granulomatous Responses Induced by Different Strains ofSchistosoma mansoni

Zuim

Allegretti

Linhares

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

View full text Add to dashboard Cite

The increased pathogenesis of the Schistosoma mansoni BH strain compared with the SJ strain has been attributed to the number of granulomas formed in experimental infections, which increase the mortality in definitive hosts. The aim of the present study was to investigate the development of granulomas around the eggs of the S. mansoni BH and SJ strains and to determine whether this host reaction was strain specific. Four experimental groups were analyzed. Two groups contained mice inoculated in the caudal vein with eggs from the S. mansoni BH or SJ strains and the other two contained mice that were infected with cercariae of the BH strain prior to being inoculated with eggs. The number of granulomas per tissue area in the lungs and liver, as well as the size of the granulomas, was analyzed to characterize the response to schistosome infection. The largest granulomatous responses were observed around eggs of the BH strain. Granulomas covered a larger area in the lungs of mice that were previously infected with cercariae and subsequently inoculated with eggs of the BH strain. These results indicated that specific granulomatous responses occurred following an infection with the BH and SJ strains of S. mansoni.

show abstract

“…The intensity of infection by S. mansoni is a better morbidity indicator than prevalence, as used in the determination of serious forms of the disease, especially the hepatosplenic form 11 . However, young people were found carrying the disease (10-19 age group) with a high parasite load (≥ 500), which may indicate recent and intense exposure to water contaminated by the parasite 8 .…”

Section: Discussionmentioning

confidence: 99%

Spatial pattern, water use and risk levels associated with the transmission of schistosomiasis on the north coast of Pernambuco, Brazil

et al. 2010

View full text Add to dashboard Cite

This study aimed to describe epidemiological aspects of schistosomiasis in Carne de IntroductionAlthough schistosomiasis is already well known as an endemic disease, new cases of acute schistosomiasis infection have been discovered on the Pernambuco coast, Brazil. There, individuals carrying the disease have migrated to coastal areas in search of better living conditions but have most commonly ended up living in places with poor health conditions. These individuals have thereby contributed to the spread of the Schistosoma mansoni in snails' breeding sites on the coast. This phenomenon can be seen through new foci of the disease vectors found in coastal and tourist areas in Pernambuco, where peridomestic foci are commonly found, and even domestically in the houses of low income families. Active transmission sites have also been detected in summer homes frequented by individuals from the middle and upper social classes 1,2,3,4,5 .Factors such as exposure time, and intensity of human contact with water contaminated by human feces, are directly related to the incidence of schistosomiasis. The pattern of human contact with water is complex and highly variable, but it serves to provide an important explanation for the epidemiological differences between infected population groups. Nevertheless, factors such as socio-economic circumstances, water supply and the provision of sewerage services also have a strong influence on the occurrence of the disease 6,7 .ARTIGO ARTICLE

show abstract

Esquistossomose na área hiperendêmica de Taquarendi: I Infecção pelo Schistosoma mansoni e formas graves

Abstract: Resumo

Cited by 29 publications

References 18 publications

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

A Study of the Granulomatous Responses Induced by Different Strains ofSchistosoma mansoni

Spatial pattern, water use and risk levels associated with the transmission of schistosomiasis on the north coast of Pernambuco, Brazil

Contact Info

Product

Resources

About