Enfermedad de Chagas-Mazza congenita en Salta

Contreras, Silvia Julieta García; Fernandez, María Rosa; Agüero, Fernando; Desse, Javier Desse; Orduña, Tomás; Martino, Olindo

doi:10.1590/s0037-86821999000600004

Cited by 19 publications

(3 citation statements)

References 10 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using direct parasitological methods, this transmission rate is comparable with those reported in the city of Cochabamba in Bolivia (4.9–5.9%; Torrico et al. 2004) or in Argentina (8.8%; Contreras et al. 1999; 7.1%; Blanco et al.…”

Section: Discussionsupporting

confidence: 80%

“…Based on the hypothesis that among the 763 infants without circulating parasites at birth and lost at the first month control, a similar proportion would have presented circulating parasites (approximately 1.1%), the incidence of congenital Chagas disease would rise to 2.6% and the congenital transmission rate to 6%. Using direct parasitological methods, this transmission rate is comparable with those reported in the city of Cochabamba in Bolivia (4.9-5.9%; Torrico et al 2004) or in Argentina (8.8%; Contreras et al 1999;7.1%;Blanco et al 2000) but higher than those reported in Brazil (1.6%; Bittencourt et al 1985;0.7%;Rassi et al 2004) or Uruguay (1.6%; Sarasua et al 1986). Only teams using molecular methods of detection have reported higher Russomando et al 1998;13.7-28.2%;Garcia et al 2001).…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia

Salas

Cot

Schneider

et al. 2007

Tropical Med Int Health

View full text Add to dashboard Cite

Summaryobjective To determine the risk factors of congenital Chagas disease and the consequences of the disease in newborns.methods Study of 2712 pregnant women and 2742 newborns in Yacuiba, south Bolivia. Chagas infection was determined serologically in mothers and parasitologically in newborns. Consequences of congenital Chagas disease were assessed clinically.results The prevalence of Chagas disease in pregnant women was 42.2%. Congenital transmission was estimated at 6% of infected mothers leading to an incidence rate of 2.6% among newborns. Main risk factors of congenital transmission were mothers' seropositivity and maternal Trypanosoma cruzi parasitaemia. Parity was higher in infected than in non-infected mothers, but it was not associated with the risk of congenital transmission. The rate of congenital infection was significantly higher in newborns from multiple pregnancies than in singletons. However, we did not observe statistically significant consequences of Chagas disease in newborns from single pregnancies or among twins.conclusions The main risk factors for congenital transmission were infection and parasitaemia of mothers. Consequences of the disease seemed mild in newborns from single pregnancies and perhaps more important in multiple births.keywords congenital Chagas disease, vertical transmission, pregnant women, newborns, Bolivia

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 66%

Risk factors and consequences of congenital Chagas disease in Yacuiba, south Bolivia

Salas

Cot

Schneider

et al. 2007

Tropical Med Int Health

View full text Add to dashboard Cite

show abstract

“…In South American countries, the prevalence of Trypanosoma cruzi seropositivity in pregnancy ranges from 0.3% to 49.5% and the transmission probability from infected mother to child has been estimated at 4.7% (95% CI: 3.9–5.6) in a meta‐analysis . Although about 90% of congenital cases are asymptomatic at birth, some cases present varied symptoms such as low weight, hepatosplenomegaly, jaundice and anaemia .…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with Chagas disease in pregnant women in Santander, a highly endemic Colombian area

Castellanos-Domínguez

Cucunubá

Orozco

et al. 2015

Tropical Med Int Health

View full text Add to dashboard Cite

ObjectiveTo determine the prevalence and risk factors associated with Chagas disease in pregnant women in an endemic area of Santander, Colombia.MethodsCross‐sectional study included 23 municipalities of Santander, Colombia. Serological IFAT and ELISA tests were undertaken to detect IgG anti‐ Trypanosoma cruzi. A questionnaire was conducted for assessing the risk factors of each participant. Newborns were evaluated at birth and followed up to 1 year of age to determine congenital infection.ResultsAn overall prevalence of 3.2% (95% CI 2.4–4.2) among 1518 pregnant women was detected. Prevalences by provinces were as follows: Guanentina: 6.0% (95% CI 4.1–8.5), García Rovira: 2.9% (95% CI: 1.5–4.8) and Comunera: 0.4% (0.4–2.3). The main risk factors identified were age >32 years old (OR: 2.1; 95% CI: 1.1–3.9); currently having a thatched roof (OR: 11.8; CI95% 2.2–63.2) and a thatched roof during childhood (OR: 3.0; 95% CI: 1.4–6.6); having below primary school education level (OR: 4.6; 95% CI: 2.2–9.5); and a history of a close contact with the vector (triatomine bugs) at least once during their lifetime (OR: 6.9; 95% CI: 3.7–12.9). No congenital cases were detected by parasitological or serological techniques.ConclusionsPrevalence of Chagas disease in pregnant women is a potential source of infection in this Colombian endemic area. The main risk factors associated with seropositivity were related to conditions favouring the contact with the vector. The results show that it is necessary to continue an active surveillance in order to offer diagnosis and treatment to mothers and their newborns in addition to screening to pregnant women from endemic areas.

show abstract