Manifestações articulares nas viroses exantemáticas

Oliveira, de; La, Camacho; Lr, Bettini; Dg, Fernandes; Na, Gouvea; Ra, Barros; Setúbal, Sérgio; Mm, Siqueira

doi:10.1590/s0037-86821999000200002

Cited by 4 publications

(7 citation statements)

References 15 publications

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“…The arthropathies associated with the recent/active B19 infection presented short duration (maximum of 10 days), symmetrical distribution and disappeared without sequelae. These clinical features have been recorded in previous studies 36,38 . In our study, the absence of chronic arthropathies associated with parvovirus B19, as previously described 34,36 , could be explained by the fact that a low number of patients (n = 13) with chronic joint symptoms (lasting months or years) were enrolled in the present study.…”

Section: Discussionsupporting

confidence: 54%

“…This fact raises the possibility that pathogens not investigated in our study be associated with the disease, as demonstrated in others regions 37,41,48,49 . Because of situations like this, 36,38,40 it has been stressed the importance of making differential diagnosis with arthropathies due to other pathogens, so that proper therapeutic measure can be taken. In our study, interfalangial joints of hands and feet were mostly affected.…”

Section: Discussionmentioning

confidence: 99%

“…In tropical climate countries, like Brazil, there have been a few reports associating these viral agent with cases of arthropathy. Overall, these studies 37,38 have shown that arthropathy is present among individuals with exanthematous illness, namely E.I, and the positivity rates usually range from 10.0 to 40.0% in men and women, respectively. It is therefore of our interest to improve our knowledge on the epidemiology/clinical features of parvovirus B19 infection in our region focussing on its potential for developing arthropathies.…”

Section: Introductionmentioning

confidence: 94%

“…In the Amazon region, arthropathy is a common finding in rubella, arboviral diseases (ex. : Oropouche and Mayaro fevers), Epstein-Barr virus infection and cytomegalovirus infection 1,23,38,51 . Among of the parasitic and bacterial agents, Toxoplasma gondii and Streptoccocus species may also cause arthropathy 19,31 .…”

Section: Introductionmentioning

confidence: 99%

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Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Freitas

Monteiro

Filho

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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A total of 220 patients with arthropathy were selected in Belém, Pará between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7% of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7%) than men (35.4%) (P = 0.0006). The age group of 11-20 years (84.6%), among female patients, and 21-30 years (42.1%), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0%) and the lowest (11.0%) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0% and 48.0% of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0% of the individuals, whereas in 46.0% of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between human parvovirus B19 and arthropathy in Belém, Pará, north Brazil

Freitas

Monteiro

Filho

et al. 2002

Rev. Inst. Med. trop. S. Paulo

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“…The confirmed diagnosis of rubella in this sample was 3.9%, lower than the percentage found in Zulia, Venezuela (1998) and in Niteroi, Rio de Janeiro, Brazil (1994 to 1998), from exanthematic diseases, with observed frequencies of 38.2% and 21.0% for rubella, respectively 12,15 . Another survey of suspected dengue cases in Yucatan, Mexico (1988 to 2001) as described by BUSTOS et al 7 showed a detection of 10.0% of subjects with rubella.…”

Section: Discussioncontrasting

confidence: 63%

Syndromic surveillance: etiologic study of acute febrile illness in dengue suspicious cases with negative serology. Brazil, Federal District, 2008

Silva

Evangelista

2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWith the aim of identifying the etiology of acute febrile illness in patients suspected of having dengue, yet with non reagent serum, a descriptive study was conducted with 144 people using secondary serum samples collected during convalescence. The study was conducted between January and May of 2008. All the exams were re-tested for dengue, which was confirmed in 11.8% (n = 17); the samples that remained negative for dengue (n = 127) were tested for rubella, with 3.9% (n = 5) positive results. Among those non reactive for rubella (n = 122), tests were made for leptospirosis and hantavirus. Positive tests for leptospirosis were 13.9% (n = 17) and none for hantavirus. Non reactive results (70.8%) were considered as Indefinite Febrile Illness (IFI). Low schooling was statistically associated with dengue, rubella and leptospirosis (p = 0.009), dyspnea was statistically associated with dengue and leptospirosis (p = 0.012), and exanthem/petechia with dengue and rubella (p = 0.001). Among those with leptospirosis, activities in empty or vacant lots showed statistical association with the disease (p = 0.013). Syndromic surveillance was shown to be an important tool in the etiologic identification of IFI in the Federal District of Brazil.

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