Efeito protetor do nifurtimox contra a reativação parasitária em pacientes cronicamente infectados pelo Trypanosoma cruzi e tratados com corticóide em virtude de afecções associadas

Abstract

Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with nifurtimox. We proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study nifurtimox use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.

Etiological treatment for infection by Trypanosoma cruzi

“…If the receptor has been infected with Chagas through a kidney or heart transplant, also as in immunodeficiency of another nature, a parasitical reactivation is expected. Benznidazole, nifurtimox and allopurinol on such occasions proved to be able to reduce the exarcebation, giving another valid indication for the aforementioned medicaments 1,6 .…”

Etiological treatment for infection by Trypanosoma cruzi

“…If the receptor has been infected with Chagas through a kidney or heart transplant, also as in immunodeficiency of another nature, a parasitical reactivation is expected. Benznidazole, nifurtimox and allopurinol on such occasions proved to be able to reduce the exarcebation, giving another valid indication for the aforementioned medicaments (Amato Neto et al 1995, Rassi et al 1998.…”