Febre maculosa no município de Pedreira, SP, Brasil. Inquérito sorológico

Abstract

Casos de febre maculosa brasileira vêm ocorrendo desde 1985 no município de Pedreira. Com o objetivo de avaliar a prevalência da febre maculosa brasileira nessa área endêmica, foram coletadas amostras únicas de soro de 473 pessoas sadias, moradores e funcionários de uma indústria de louças. As amostras obtidas foram testadas através da reação de imunofluorescência indireta (IFA), para determinação do título de anticorpos para ricketttsia do grupo da febre maculosa brasileira. Vinte e cinco (5,3%) foram considerados positivos (título &sup3;1:64) e trinta e um (6,5%) apresentaram título igual a 1:32 ("borderline"). Os resultados evidenciam uma taxa de soropositividade semelhante a outras áreas reconhecidamente endêmicas do país.<br>Cases of Brasilian spotted fever (BSF) have been occurred since 1985, in the rural area of Pedreira town, situated 160km away from the city of São Paulo (longitude 46o54'07"; latitude 22o44'21"). Aiming at evaluating the prevalence of Brasilian spotted fever in this endemic area, single-serum samples were collected from 473 healthy persons, amongst city-dwellers and the local china industry workers. The obtained samples were tested by indirect immunofluorescence (IFA), in order to determine the antibodies titer for the group of Brasilian spotted fever. Twenty-five (5.3%) were considered positive (titer 3 1:64) and thirty-one (6.5%) were taken as "borderline" (titer 1:32). The results show a serologically positivity rate similar to other areas, known as endemic ones within the country

Antibodies to Rickettsia rickettsii, Rickettsia typhi, Coxiella burnetii, Bartonella henselae, Bartonella quintana, and Ehrlichia chaffeensis among healthy population in Minas Gerais, Brazil

“…As compared with other Brazilian seroprevalence studies the rate found here for R. rickettsii was low. Lemos et al (1994Lemos et al ( , 2001), Del Guercio et al (1997), and Galvão et al (2002) found respectively 7.14, 4.2, 5.3, and 10.1% seroprevalence rates in different serosurveys. Despite this low seroprevalence rate, spotted fever group rickettsioses have been increasing in the studied region with an incidence of over 0.5/100,000 inhabitants-year (Costa 2004) compatible with the ongoing epidemic expansion recently reported from some Brazilian southeast regions (Rozental et al 2002, Galvão et al 2003.…”

“…Except for the R. rickettsii (Lemos et al 1994, Del Guercio et al 1997, Rozental et al 2002) seroepidemiologic data on rickettsial infections is missing in Brazil although null seroprevalence for R. typhi and E. chaffeensis infections has been reported in one recent study by Galvão et al (2002). This same author however, previously reported in his PhD thesis, the presence of antibodies for R. typhi in 3% of humans from Caratinga, state of Minas Gerais, Brazil (Galvão 1996).…”

“…The seroprevalence rates for R. rickettsii, R. typhi, C. burnetii, B. henselae, B. quintana, and E. chaffeensis were respectively 1.6% (7 samples (WHO 1993, Rozental et al 2002, Walker 2004a. Until recently the rickettsiales order comprised the genus Rickettsia, Coxiella, Bartonella, Orientia, Anaplasma, and Ehrlichia (Raoult & Roux 1997) and despite of the resulting withdraw of some of them from this order especially due to 16S rRNA studies, they all can be functionally considered rickettsial agents (Raoult & Roux 1997, Walker 2004b.Most of the available publications of Brazilian rickettsial infections have focused on spotted fever group rickettsioses especially R. rickettsii infections (Lemos et al 1994, Del Guercio et al 1997, Rozental et al 2002, Galvão et al 2003. This issue has been extensively reviewed recently by Galvão (2004).…”

“…Most of the available publications of Brazilian rickettsial infections have focused on spotted fever group rickettsioses especially R. rickettsii infections (Lemos et al 1994, Del Guercio et al 1997, Rozental et al 2002, Galvão et al 2003. This issue has been extensively reviewed recently by Galvão (2004).…”

Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution

“…In 1985, three individuals living in the city of Pedreira, in the region of Campinas, São Paulo, presented with symptoms that were compatible with BSF, which was confirmed by clinical diagnosis 14,15 . Up until that moment, there had been no records of the condition in the region 16 .…”