Estudos de variáveis que podem influenciar na evolução da forma hepatoesplênica da esquistossomose: efeito da terapêutica específica e da interrupção da transmissão

Bina, José Carlos

doi:10.1590/s0037-86821996000600022

Cited by 8 publications

(12 citation statements)

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“…Others have also demonstrated regression of hepatic lesions after schistosomicidal drug treatment. 2,21,22 Sleigh and others in a three year follow-up without treatment described progression of hepatomegaly by clinical examination in 83% of patients and development of splenomegaly in 10% of patients with Ͼ 100 eggs/g stool. 23 No previous publication has assessed progression of hepatic lesions by ultrasonography without treatment.…”

Section: Discussionmentioning

confidence: 96%

“…1,2 The hepatic lesion is caused by a granulomatous response to eggs of S. mansoni with subsequent periportal fibrosis, portal hypertension, splenomegaly, esophageal varices, and recurrent hematemesis. [3][4][5] Periodic treatment with schistosomicidal drugs has greatly reduced the severe form of the disease, making it difficult to assess morbidity by clinical examination.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] Periodic treatment with schistosomicidal drugs has greatly reduced the severe form of the disease, making it difficult to assess morbidity by clinical examination. 2,6,7 Since the primary objective of a control program should be the reduction and prevention of morbidity, it is important to evaluate the methods used to detect hepatic fibrosis. Ultrasonography has become a valuable tool in the assessment of morbidity due to S. mansoni infection.…”

Section: Introductionmentioning

confidence: 99%

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Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura.

Jesus¹,

Miranda²,

Miranda³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura.

Jesus¹,

Miranda²,

Miranda³

et al. 2000

The American Journal of Tropical Medicine and Hygiene

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“…Although treatment of infected people with schistosomicidal drugs has in part controlled the morbidity of the disease, transmission is largely unaltered (3,5,24). The possibility of a schistosomiasis vaccine as an additional measure to control the disease arose from the fact that the parasite does not multiply in human beings and that reduction of infection levels by schistosomicidal drugs reduces the prevalence of severe forms of the disease.…”

mentioning

confidence: 99%

Human Immune Responses toSchistosoma mansoniVaccine Candidate Antigens

et al. 2000

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To determine the naturally occurring immunological responses to the Schistosoma mansoni antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including "resistant" subjects (n ‫؍‬ 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and the cytokine profile in culture supernatants from antigen-stimulated peripheral blood mononuclear cells (PBMC) were determined. Although all the subjects had a high degree of contaminated water exposure, their infection levels were variable (0 to 1,128 eggs/g of stool). There were direct correlations between infection levels and levels of SWAP-and paramyosin-specific IgG1 and IgG4 (P < 0.05). However, an inverse correlation between infection levels and specific IgG2 to IrV-5 (P < 0.01) was observed. The evaluation of the cytokine profile (interleukin 5 [IL-5], IL-10, gamma interferon [IFN-␥], and tumor necrosis factor alpha) in response to these antigens showed inverse correlations between the degree of infection and IFN-␥ levels in PBMC supernatants stimulated with paramyosin (P < 0.05) and IrV-5 (P < 0.01). Additionally, inverse correlations between the degree of infection and IL-5 levels in MAP-3-and MAP-4-stimulated PBMC supernatants (P < 0.01) were found. Logistic regression analysis was performed to adjust the results of cytokine profile by age. IL-5 production in MAP-3-stimulated PBMC supernatants was associated with lower infection levels (odds ratio ‫؍‬ 11.2 [95% confidence interval, 2.7 to 45.8]).Schistosomiasis is a chronic parasitic infection that affects 200 million people in Africa, South America, and Asia (35). Although treatment of infected people with schistosomicidal drugs has in part controlled the morbidity of the disease, transmission is largely unaltered (3,5,24). The possibility of a schistosomiasis vaccine as an additional measure to control the disease arose from the fact that the parasite does not multiply in human beings and that reduction of infection levels by schistosomicidal drugs reduces the prevalence of severe forms of the disease. Moreover, in experimental models, partial immunity can be induced by vaccination with irradiated cercariae or specific antigens (2,11,14,26,36,37,58,59). Immunological studies of subjects from areas of endemicity have demonstrated a naturally occurring resistance to reinfection (4, 19, 22-25, 27, 28). Both high levels of specific immunoglobulin E (IgE) in sera and gamma interferon (IFN-␥) in antigen-stimulated peripheral blood mononuclear cell (PBMC) cultures were associated with resistance to reinfection (1,22,24,25,27,28,56,57). These data suggest the participation of immunological mechanisms in human resistance to Schistosoma mansoni infection, with mixed cellular and humoral responses.Several S. mansoni antigens have been identified and tested in experimental models, with the induction of variable levels of protection against infection (11,32,49,59,61,(68)...

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“…The development of hepatosplenic disease, with its accompanying periportal fibrosis and intra-hepatic vascular obstruction rarely occurs in infected patients migrating away from an endemic area 6 . Transmission control in an isolated endemic area of the state of Bahia, Brazil, was followed by amelioration of clinical manifestations and by suppression of hepatosplenic disease development 4 . Experimentally, periovular granulomas are larger 5 and periportal fibrosis more frequent in mice subjected to repeated schistosomal infections 14 .…”

Section: Discussionmentioning

confidence: 99%

Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections

Oliveira¹,

Souza

Andrade

2004

Rev. Soc. Bras. Med. Trop.

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Estudos de variáveis que podem influenciar na evolução da forma hepatoesplênica da esquistossomose: efeito da terapêutica específica e da interrupção da transmissão

Cited by 8 publications

References 0 publications

Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura.

Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura.

Human Immune Responses toSchistosoma mansoniVaccine Candidate Antigens

Capillaria hepatica-induced hepatic fibrosis in rats: paradoxical effect of repeated infections

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