Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil

França, Francisco Oscar de Siqueira; Lago, Ednaldo; Marsden, Philip D.

doi:10.1590/s0037-86821996000300002

Cited by 113 publications

(76 citation statements)

References 10 publications

(1 reference statement)

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“…Although Brazil is the major exporter of cashew nut, the cashew tree is the source of many useful products, including the pseudo-fruit (cashew apple) that is used to make juices and wines (Aguiar et al, 2001). Also, the fruits, stem bark and leaves extracts have been traditionally used for the treatment of mouth and peptic ulcers, intestinal disturbances, dyspepsia, asthma, diabetes, sore throat, asthma, bronchitis and inflammatory diseases (Correia, 1984;Lorenzi & Matos, 2002;Luiz-Ferreira et al, 2008), as well as in treatment Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the Maria I. G. Silva et al of leishmanial ulcers due to Leishmania (Viannia) braziliensis (Franca et al, 1996).…”

Section: Anadenanthera Colubrina (Vell) Brenan Fabaceae (Angico-bramentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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Section: Anadenanthera Colubrina (Vell) Brenan Fabaceae (Angico-bramentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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“…Os temas predominantemente abordados tratam exclusivamente de investigações sobre plantas medicinais, com aproximadamente 64% das publicações (Elisabetsky & Castilhos 1990;Brandão et al 1992;Teixeira et al 1992;Vieira & Skorupa 1993;Di Stasi et al 1994;Jacomassi & Piedade 1994;Almeida et al 1995;Baracho & Agra 1995;Santos et al 1995;Stehmann & Brandão 1995;Albuquerque & Silva-Soares 1996;França et al 1996;Grob et al 1996;Leal & Elisabetsky 1996;Rocha & Agra 1996;Amorozo 1997;Freire et al 1997;Gilbert et al 1997;Guarim Neto 1997;Pinheiro 1997 Begossi et al 2002;Di Stasi et al 2002;Ghedini et al 2002;Holetz et al 2002;Melo Júnior et al 2002;Moreira et al 2002;Peres et al 2002;Rodrigues et al 2002;Sangalli et al 2002 Arjona et al 2007;Cruz et al 2007;Dickel et al 2007;Giorgetti et al 2007;Guerra et al 2007;Leão et al 2007;MaioliAzevedo e Fonseca-Kruel 2007;Marinho et al 2007;Negrelle e Fornazzari 2007;…”

Section: A Etnobotânica Em Artigos Científicosunclassified

Avanços nas pesquisas etnobotânicas no Brasil

et al. 2009

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RESUMO -(Avanços nas pesquisas etnobotânicas no Brasil). A Etnobotânica moderna é produto de mudanças históricas ocorridas dentro e fora da academia. O trabalho buscou traçar a trajetória dessa disciplina e suas tendências no Brasil. Para tal foi realizado um levantamento dos trabalhos, no período de 1968-2007, desenvolvidos por pesquisadores brasileiros no país e publicados nas revistas científicas de circulação nacional, internacional e em eventos nacionais. O artigo discute sobre o desenvolvimento da Etnobotânica e sobre a crescente valorização do conhecimento construído por populações não-industrializadas. Neste contexto destaca-se a influência das mudanças de interesses científicos e econômicos ao longo dos períodos avaliados e, especialmente, da implementação da Convenção sobre Diversidade Biológica. O desenvolvimento da Etnobotânica teve um impacto sobre a produção científica brasileira e refletiu em um notório incremento de trabalhos nesta área do conhecimento, porém ainda com predominância de estudos relacionados a plantas medicinais e/ou abordagens descritivas. Por fim, são tecidas algumas considerações sobre a atual situação da Etnobotânica no Brasil face às regulamentações legais determinadas pela Convenção sobre Diversidade Biológica.Palavras-chave: América Latina, botânica econômica, conhecimento tradicional, etnobiologia, etnoecologia, histórico da etnobotânica ABSTRACT -(Advances in ethnobotany research in Brazil). Modern Ethnobotany is a product of historical changes occurring inside and outside of the academy. The following article aimed to trace the trajectory and tendencies of Ethnobotany in Brazil. For this purpose, a review was performed of works which were developed by Brazilian researchers between 1968-2007, and published in scientific journals of either national or international scope and during national events. The article discusses the development of Ethnobotany and the increased value of the knowledge of non-industrialized peoples. In this context, the influences that stand out are changes in scientific and economic interests during the period evaluated and, especially, the implementation of the Convention on Biological Diversity. The development of Ethnobotany had an impact on Brazilian scientific production and caused a notable increase of works in this knowledge area, yet with the predominance of studies still regarding medicinal plants and/or descriptive approaches. Finally, we discuss the current situation in Brazilian Ethnobotany, in the context of the legal regulations determined by the Convention on Biological Diversity.

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“…Natural products obtained from a wide range of plant species, such as essential oils, have been traditionally used to treat a number of diseases, including leishmaniasis (Hammer and Johns, 1993;Franca et al, 1996;Bezerra et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

et al. 2012

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Leishamaniasis is a disease that aff ects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal eff ects of a thymol-and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed signifi cant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more eff ective, with IC 50 /72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC 50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds.

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Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil

Cited by 113 publications

References 10 publications

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Avanços nas pesquisas etnobotânicas no Brasil

Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham

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