Reação de fase aguda e parasitismo na veia central da supra-renal de chagásicos crônicos

Abstract

The systemic reaction to severe trauma and/or infection, acute phase response (APR), are often associated with immunosuppression and reactivation of chronic latent infection. Our main purpose was to verify, in a group of 71 autopsied chronic chagasic with or without APR, the frequency of T. cruzi nests in the central vein of adrenal gland (CVAG). APR, defined by: 1) death secondary to sepsis and/or trauma plus, 2) bleeding stress gastric ulcerations or 3) spleen reactional state or 4) liver steatosis, was observed in 30 chronic chagasic (APR+). Weight, height and body mass index (BMI) were obtained. APR(+) chronic chagasic had worse nutritional status than APR(-) ones: weight = 49.0 vs 54.5 kg; BMI = 17.5 vs 20.6 kg/m2 (median p < 0.05). CVAG T. cruzi nests frequency were similar (43.3% and 43.9%, respectively) between both Groups. We conclude that APR(+) chronic chagasic had worse nutritional status than APR(-) ones, and that APR development did not change the CVAG T. cruzi nests frequency.

Resposta de fase aguda, subnutrição e estado nutricional do ferro em adultos com AIDS

“…Embora não observados no presente estudo, a má absorção associada com a diarréia crônica e a ingestão alimentar reduzida secundária à Tabela 1 -Peso corporal, dados laboratoriais do metabolismo do ferro e ingestão diária de energia, ferro e ácido ascórbico de 29 pacientes HIV-positivos, com ou sem resposta de fase aguda (RFA). No presente estudo, documentou-se que anemia e subnutrição são comuns em adultos com AIDS, sendo mais freqüentes nos pacientes com a síndrome da RFA, resultados similares aos observados em indivíduos chagásicos, falecidos com a síndrome da resposta de fase aguda secundária à sepsis ou ao traumatismo grave 8 . Embora critérios antropométricos sejam mais precisos na definição do marasmo, em que há balanço energético negativo e desgaste progressivo da gordura corporal 13 , o emprego do índice creatinina-altura também permitiu documentar a menor massa muscular nos pacientes com AIDS que desenvolveram RFA.…”

The MASP Family of Trypanosoma cruzi: Changes in Gene Expression and Antigenic Profile during the Acute Phase of Experimental Infection

“…As an attempt to investigate whether MASP members could be implicated in interactions with specific cell types, we investigate the MASP expression profile in trypomastigotes derived from epithelial (LLC-MK2) and myoblast (L6) cell lines. We selected these cell types because LLC-MK2 is widely used for maintaining T. cruzi in in vitro culture, whereas myoblasts give raise to muscle cells, which are target by T. cruzi during acute and chronic phase of Chagas disease [26], [49]. We did not detected significant changes in the MASP expression profile between these two host cells after 4 passages in tissue culture.…”

Pressure sores among malnourished necropsied adults - preliminary data

“…Acute phase response syndrome, a condition associated with positive body water balance trend, was defined by death associated with severe infection (purulent peritonitis, bilateral pneumonia, acute pancreatitis, bacterial meningitis, acute bacterial endocarditis, acute bilateral pyelonephritis, pulmonary or disseminated tuberculosis), or massive brain or mesenteric infarction, plus gastric stress ulcers and/or spleen reactional state 6 . Stress ulcers were defined as the presence of ulcerative, superficial, necrotic or necro-hemorrhagic ulcers, often multiple, located in the gastric or duodenal mucosa.…”