2012
DOI: 10.1371/journal.pntd.0001779
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Abstract: Background Trypanosoma cruzi is the etiological agent of Chagas disease, a debilitating illness that affects millions of people in the Americas. A major finding of the T. cruzi genome project was the discovery of a novel multigene family composed of approximately 1,300 genes that encode mucin-associated surface proteins (MASPs). The high level of polymorphism of the MASP family associated with its localization at the surface of infective forms of the parasite suggests that MASP participates in host–parasite in… Show more

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Cited by 53 publications
(66 citation statements)
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“…On the other hand, the multigene family MASP was discovered when the parasite's genome was sequenced and annotated, and is a good example of how a genome project shed light into the structure of a genome [11], [17], [51]. Although the MASP family is composed by a very large number of genes (>1400), the delay in its identification was probably due to its unusual or not-so-abundant protein expression pattern.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, the multigene family MASP was discovered when the parasite's genome was sequenced and annotated, and is a good example of how a genome project shed light into the structure of a genome [11], [17], [51]. Although the MASP family is composed by a very large number of genes (>1400), the delay in its identification was probably due to its unusual or not-so-abundant protein expression pattern.…”
Section: Discussionmentioning
confidence: 99%
“…The trypomastigote coat is apparently formed by two juxtaposed layers of heavily O -glycosylated mucins and, underneath, glycoinositolphospholipids ( GIPLs) [911], with other less prevalent glycoproteins such as trans -sialidase (TS) [12], mucin-associated surface proteins (MASPs) [13], Gp85 surface glycoproteins [14], trypomastigote small surface antigen (TSSA) [15] and Tol-T antigens [16] speckled on this coat. All of these, except for the GIPLs, are encoded by highly polymorphic and developmentally-regulated gene families [17] bearing a similar predicted architecture, in which the outermost N- terminal adhesive domain likely protrudes from the ~15nm thick, mucin O -glycan canopy.…”
Section: Trypanosoma Cruzi: Dressed For Successmentioning
confidence: 99%
“…In this parasite, a large repository of antigenically distinct 'donor' VSGs, which are scattered along silent sites in the genome, are moved by recombination into an active VSG expression site [75]. By contrast, the intracellular parasite T. cruzi does not use this strategy of antigenic variation for host immune evasion but instead relies on the simultaneous display of multiple polymorphic glycoproteins (e.g., mucins, trans-sialidases, mucin-associated proteins) on its surface during its mammal-dwelling stages [22,76,77]. The presence of a mosaic antigenic coat could modulate the mammalian host immune response by impairing the development of highly-specific lymphocytes and/or facilitate the recognition of the broad spectrum of cell types and mammalian hosts infected by this parasite [22,76].…”
Section: Non-sexual Mechanisms Of Generating Diversity and Variation mentioning
confidence: 99%
“…By contrast, the intracellular parasite T. cruzi does not use this strategy of antigenic variation for host immune evasion but instead relies on the simultaneous display of multiple polymorphic glycoproteins (e.g., mucins, trans-sialidases, mucin-associated proteins) on its surface during its mammal-dwelling stages [22,76,77]. The presence of a mosaic antigenic coat could modulate the mammalian host immune response by impairing the development of highly-specific lymphocytes and/or facilitate the recognition of the broad spectrum of cell types and mammalian hosts infected by this parasite [22,76]. Cumulative functional data (reviewed in [23]) and the recent finding of a significantly smaller number of gene copies encoding mucins, trans-sialidases, and mucin-associated proteins in the genome of a closely related species, the avirulent human-infective Trypanosoma rangeli further support a role for these molecules in T. cruzi pathogenesis [78].…”
Section: Non-sexual Mechanisms Of Generating Diversity and Variation mentioning
confidence: 99%