Atividade moluscicida da mistura de ácidos 6-n-alquil salicílicos (ácido anacárdico) e dos seus complexos com cobre (II) e chumbo (II)

Nm, Mendes; Oliveira, Adriano Bof de; Je, Guimarães; Jp, Pereira; Katz, Néstor E.

doi:10.1590/s0037-86821990000400007

Cited by 11 publications

(8 citation statements)

References 5 publications

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“…The anacardic acids are interesting phenolic compounds due to their wide bioactivities, such as antibacterial [ 12 ], antioxidant, larvicide, and acetylcholinesterase activities [ 3 ]. Furthermore, it is a potent insecticide and molluscicide [ 13 ], an inhibitor of several enzymes [ 14 , 15 ]. Anacardic acid functions are also potent tumor angiogenesis inhibitors by targeting the Src/FAK/Rho GTPase signaling pathway, leading to significant suppression of prostate tumor growth [ 4 ].…”

Section: Resultsmentioning

confidence: 99%

Anacardic Acid Constituents from Cashew Nut Shell Liquid: NMR Characterization and the Effect of Unsaturation on Its Biological Activities

et al. 2017

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Anacardic acids are the main constituents of natural cashew nut shell liquid (CNSL), obtained via the extraction of cashew shells with hexane at room temperature. This raw material presents high technological potential due to its various biological properties. The main components of CNSL are the anacardic acids, salicylic acid derivatives presenting a side chain of fifteen carbon atoms with different degrees of unsaturation (monoene–15:1, diene–15:2, and triene–15:3). Each constituent was isolated by column chromatography using silica gel impregnated with silver nitrate. The structures of the compounds were characterized by nuclear magnetic resonance through complete and unequivocal proton and carbon assignments. The effect of the side chain unsaturation was also evaluated in relation to antioxidant, antifungal and anticholinesterase activities, and toxicity against Artemia salina. The triene anacardic acid provided better results in antioxidant activity assessed by the inhibition of the free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), higher cytotoxicity against A. salina, and acetylcholinesterase (AChE) inhibition. Thus, increasing the unsaturation of the side chain of anacardic acid increases its action against free radicals, AChE enzyme, and A. salina nauplii. In relation to antifungal activity, an inverse result was obtained, and the linearity of the molecule plays an important role, with monoene being the most active. In conclusion, the changes in structure of anacardic acids, which cause differences in polarity, contribute to the increase or decrease in the biological activity assessed.

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Section: Resultsmentioning

confidence: 99%

Anacardic Acid Constituents from Cashew Nut Shell Liquid: NMR Characterization and the Effect of Unsaturation on Its Biological Activities

et al. 2017

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“…Anacardic acids, one of the phytochemical constituents of cashew extract, has been shown to curb the darkening effect of aging by inhibiting tyrosinase activities and kill certain cancer cells[10]. Mendes[10] has documented a wide range of chemicals isolated and identified from cashew.…”

mentioning

confidence: 99%

“…Mendes[10] has documented a wide range of chemicals isolated and identified from cashew. They included anacardic acids, anacardol, hydroxybenzoic acid, kaempferol, salicylic acid and tannins.…”

mentioning

confidence: 99%

Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Okonkwo¹,

Okorie²,

Okonta³

et al. 2010

Indian J Pharm Sci

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The extracts of Anacardium occidentale have been used in the management of different cardiovascular disorders in Nigeria. These have necessitated the assessment of the toxicity of this plant extract in sub-chronic administration. The inner stem bark of Anacardium occidentale was extracted with 80 % methanol and quantitatively analysed for antinutrients and some heavy metals. The phytochemical compositions and acute toxicity of the extract were determined also. Toxicity profiles of the extract on some liver function parameters were evaluated following a sub-chronic oral administration at doses of 1.44 and 2.87 g/kg. The phytochemical screening of extract revealed the presence of high amount of tannins, moderate saponins and trace of free reducing sugars. The antinutrient levels were 5.75 % (tannins), 2.50 % (oxalates), 2.00 % (saponins), 0.25 % (phytate) and 0.03 % (cyanide). The quantity of iron detected from dried crude was 8.92 mg/100 g, while lead and cadmium were non-detectable. The extract had LD50of 2.154g/kg p.o. in mice. Sub-chronic administration of the extract significantly increased the serum levels of alanine aminotransaminase and aspartate aminotransaminase, which are indicative of liver damage. The serum levels of alkaline phosphatase and total protein of the treated animals were not significantly increased. The effects of sub-chronically administered extract on hepatocytes were minimal as the serum alkaline phosphatase; total bilirubin and total protein levels in treated animals were not significant (p< 0.05). Thus, sub-chronic administrations of Anacardium occidentale inner stem bark extract did not significantly (p< 0.05) depress the function of hepatocytes in Wistar rats.

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“…Metal complexes were synthesised using cobalt chloride hexahydrate, copper sulphate pentahydrate, and zinc acetate dihydrate using a modified method of Mendes et al 21 Cardol (C2), together with its nitrated compound were used as binders at a stoichiometric ratio of 1:1 under constant magnetic stirring.…”

Section: Formation Of Metal (Ii) Complexes Of Cardol and Nitrocardolmentioning

confidence: 99%

Antimicrobial Evaluation of Cardol and Cardol-Metal Complexes from the Nut Shell Liquid of <I>Anacardium occidentale</I>

2023

TJNPR

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Cardol, as one of the major constituents of Cashew Nut Shell Liquids has received little attention in terms of modification and applications. The presence of two hydroxyl groups and an alkyl side chain of 15 carbon length make it a natural compound of interest. The present study is aimed at modification and complexation of cardol, and the antimicrobial investigations of the compound as well as its analogue and complexes. Isolated cardol from cashew nut shell liquid was nitrated, and the compounds were used in the synthesis of metal (II) complexes of Copper, Cobalt, and Zinc. The compounds and complexes were characterised by melting points, UV-Vis spectrophotometry, Fourier Transform Infrared (FTIR) spectrophotometry, and Nuclear Magnetic resonance (NMR) spectroscopy. The antibacterial and antifungal evaluations of both the compounds and complexes were tested in vitro against some selected bacteria and fungi. From the results, Copper complex of nitrocardol produced significantly higher antibacterial zone of inhibition (11.5 ± 2.1 mm) against Pedobacter mendelii than tetracycline while Copper complex of cardol showed significantly higher antifungal activity (13.5 ± 2.1 mm) against Rhizopus stolonifar than clotrimazole (10.0 ± 0.0 mm). It was generally observed that modification and metal complexation enhanced the antimicrobial activity of cardol. Further studies on these complexes could be done to enhance their potencies and potentials for use as antibacterial and antifungal agents.

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Atividade moluscicida da mistura de ácidos 6-n-alquil salicílicos (ácido anacárdico) e dos seus complexos com cobre (II) e chumbo (II)

Cited by 11 publications

References 5 publications

Anacardic Acid Constituents from Cashew Nut Shell Liquid: NMR Characterization and the Effect of Unsaturation on Its Biological Activities

Anacardic Acid Constituents from Cashew Nut Shell Liquid: NMR Characterization and the Effect of Unsaturation on Its Biological Activities

Sub-chronic hepatotoxicity of Anacardium occidentale (Anacardiaceae) inner stem bark extract in rats

Antimicrobial Evaluation of Cardol and Cardol-Metal Complexes from the Nut Shell Liquid of <I>Anacardium occidentale</I>

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