The effect of ginger on the pharmacokinectic of metronidazole was studied using rabbits in a crossover study method. The relevance of this study borders on the wide use of ginger for culinary and phytotherapeutic purposes, and metronidazole that is commonly used for every gastrointestinal complain in our communities without prescription. Ginger significantly increased the absorption and plasma half-life, and significantly decreased the elimination rate constant and clearance of metronidazole (P<0.05). Thus, in clinical practice, the patients should be advised on the serious implication of using both items together.

The extracts of Anacardium occidentale have been used in the management of different cardiovascular disorders in Nigeria. These have necessitated the assessment of the toxicity of this plant extract in sub-chronic administration. The inner stem bark of Anacardium occidentale was extracted with 80 % methanol and quantitatively analysed for antinutrients and some heavy metals. The phytochemical compositions and acute toxicity of the extract were determined also. Toxicity profiles of the extract on some liver function parameters were evaluated following a sub-chronic oral administration at doses of 1.44 and 2.87 g/kg. The phytochemical screening of extract revealed the presence of high amount of tannins, moderate saponins and trace of free reducing sugars. The antinutrient levels were 5.75 % (tannins), 2.50 % (oxalates), 2.00 % (saponins), 0.25 % (phytate) and 0.03 % (cyanide). The quantity of iron detected from dried crude was 8.92 mg/100 g, while lead and cadmium were non-detectable. The extract had LD50of 2.154g/kg p.o. in mice. Sub-chronic administration of the extract significantly increased the serum levels of alanine aminotransaminase and aspartate aminotransaminase, which are indicative of liver damage. The serum levels of alkaline phosphatase and total protein of the treated animals were not significantly increased. The effects of sub-chronically administered extract on hepatocytes were minimal as the serum alkaline phosphatase; total bilirubin and total protein levels in treated animals were not significant (p< 0.05). Thus, sub-chronic administrations of Anacardium occidentale inner stem bark extract did not significantly (p< 0.05) depress the function of hepatocytes in Wistar rats.

The questionnaire developed is a reliable and valid instrument for assessing patient satisfaction with pharmaceutical care in HIV clinics in Nigeria. Further research is needed to expand the instruments' robustness.

To evaluate the efficacy of a pharmacist implemented educational treatment programme in improving knowledge and perception of epilepsy among people with the condition. Method: A randomized controlled study was conducted on patients with epilepsy recruited from the medical and neurology outpatient clinics of two tertiary hospitals. Patients in the intervention group were offered an educational treatment programme implemented by a clinical pharmacist. The impact of the educational intervention was evaluated by using an epilepsy knowledge scale and the brief illness perception questionnaire. Results: There was a statistical significant difference between the control and intervention group over time on the knowledge of epilepsy, as the knowledge of epilepsy among patients in the intervention group significantly increased; F (2154) = 150.15, p = 0.000, Partial η 2 = 0.661. Also, there was a statistical significant difference between the control and intervention group over time on the perception of epilepsy, as the perception of epilepsy among patients in the intervention group significantly improved; F (2, 154) = 12.386, p = 0.000, Partial η 2 = 0.138. Conclusion: The Pharmacist implemented educational intervention improved patients' knowledge and perception of epilepsy. This finding has revealed the potential positive impact of pharmacists' involvement in the management of epilepsy.

Background There is increasing prevalence of diseases associated with ageing such as hypertension, among people living with HIV (PLWHV). This study sought to assess: (1) knowledge related to HIV infection and hypertension, (2) adherence to prescribed medications and (3) clinical outcomes among HIV-positive persons with hypertension at a Nigerian hospital. Methods The Patient’s HIV Knowledge Questionnaire (PHKQ), Hypertension Knowledge-Level Scale (HK-LS) and Adherence to Refills and Medication Scale (ARMS) were administered to 220 eligible patients through the HIV clinic. Demographic and clinical data were also obtained. Results Participants were predominantly females (57.3%), with a median (IQR) age of 46 (38–58) years; majority were married (67.8%) and employed (60.8%). Participants reported a higher hypertension-related knowledge compared with HIV-related knowledge (63.6% versus 33.3%, Z = −10.263, P &lt; 0.001), but better adherence to antiretroviral medications compared to antihypertensives (100.0% versus 89.3%, Z = −9.118, P &lt; 0.001). Of the 98 participants with documented viral load, 55 (56.1%) had undetectable (&lt;40 copies/ml) values; however, only four (2.0%) of the entire sample had controlled (&lt;140/90 mmHg) blood pressure. Conclusions Despite having a higher hypertension-related knowledge, adherence to antihypertensive medications and blood pressure control were poor. There is a need for increased attention to HIV education and comorbidities in PLWHV.