Inquérito sobre presença de HBsAg em habitantes de Lábrea-Amazonas

Alecrim, Wilson Duarte; Marreiros, L. S; Alecrim, Maria G. C.; Santos, I. K. F. Miranda

doi:10.1590/s0037-86821986000100013

Cited by 7 publications

(3 citation statements)

References 1 publication

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“…Considering the rates of past infection reported before the introduction of the vaccine, which showed important variations (for example, from 15 to 32% for those up to five years old) [23][24] , the rate of less than 15% among those 3-4 years old reported in the present study suggests some impact of the vaccination program on new infections, especially among younger people. Still, we must be cautious with any conclusions because the majority of previous studies done in this region before the introduction of the HBV vaccine were analyses of non-probabilistic samples.…”

Section: Discussionmentioning

confidence: 67%

Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon

Braga

Castilho

Borges

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination. Methods: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Lábrea following nineteen years of HBV vaccination. Results: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003. Conclusions: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups.

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Section: Discussionmentioning

confidence: 67%

Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon

Braga

Castilho

Borges

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…A number of works in the literature have used serological markers in indigenous peoples 2,3,5,15,22 . All these studies also report a high prevalence of HBV.…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…Although it is preventable through vaccination, an estimated two billion people are infected around the world, with more than 350 million showing serological markers of active infection 1 . The Brazilian Amazonian region is characterized as having one of the highest levels of HBV occurrence in the world, with the basins of the Juruá-Purus and Middle-Solimões Rivers showing the most elevated rates [2][3][4] . Seroepidemiological studies among the indigenous population of this area have shown a rate of 9.7% for hepatitis B surface antigen (HBsAg) in chronic carriers 5 .…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of hepatitis B virus among the indigenous population of the Curuçá and Itaquaí Rivers, Javari Valley, State of Amazonas, Brazil

Costa

Kimura

2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Hepatitis B virus (HBV) infection is one of the most serious public health problems in the world. In Brazil, HBV endemicity is heterogeneous, with the highest disease prevalence in the North region. Methods: A total of 180 samples were analyzed and subjected to polymerase chain reaction (PCR) and semi-nested PCR of the HBV S-gene, with the aim of determining the prevalence of HBV-DNA (deoxyribonucleic acid) in indigenous groups inhabiting the areas near the Curuçá and Itaquaí Rivers in the Javari Valley, State of Amazonas, Brazil. Results: The prevalence of the HBV-DNA S-gene was 51.1% (92/180). The analysis found 18 of 49 (36.7%) samples from the Marubo tribe, 68 of 125 (54.4%) from the Kanamary, and 6 of 6 (100%) from other ethnic groups to be PCR positive. There was no statistically significant difference in gender at 5% (p=0.889). Indigenous people with positive PCR for HBV-DNA had a lower median age (p<0.001) of 23 years. There was no statistical difference found in relation to sources of contamination or clinical aspects with the PCR results, except for fever (p<0.001). The high prevalence of HBV-DNA of 75% (15/20) in pregnant women (p=0.009) demonstrates an association with vertical transmission. Conclusions: The results confirm the high prevalence of HBV-DNA in the Javari Valley, making it important to devise strategies for control and more effective prevention in combating the spread of HBV.

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Prevalência de marcadores sorológicos de hepatite B numa pequena comunidade rural do Estado de São Paulo, Brasil

et al. 1992

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Foi realizado estudo epidemiológico com vistas a determinar a prevalência de marcadores sorológicos de hepatite B na população de um pequeno município, de características rurais, do Estado de São Paulo. Observou-se prevalência total de marcadores igual a 7,74%, com valores de HBsAg, anti-HBs e anti-HBc, respectivamente iguais a 0,10%, 1,69% e 7,64%. Ressalta-se a importância da determinação do anti-HBc em estudos epidemiológicos, bem como discute-se a relevância de se comparar a reduzida circulação viral, observada na área, com as elevadas prevalências verificadas em outras regiões, buscando assim levantar hipóteses acerca de mecanismos alternativos de transmissão.

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Inquérito sobre presença de HBsAg em habitantes de Lábrea-Amazonas

Cited by 7 publications

References 1 publication

Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon

Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon

Molecular epidemiology of hepatitis B virus among the indigenous population of the Curuçá and Itaquaí Rivers, Javari Valley, State of Amazonas, Brazil

Prevalência de marcadores sorológicos de hepatite B numa pequena comunidade rural do Estado de São Paulo, Brasil

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