Primeiros casos agudos autóctones da doença de Chagas no Maranhão e inquérito soro-epidemiológico da população

Silva, Antônio Rafael da; Mendes, José Ribamar Borges; Mendonça, María Luiza Martins de; Cutrim, Raimundo Nonato; Brazil, Reginaldo Peçanha

doi:10.1590/s0037-86821985000400013

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…The (19)(20)(21)(22)(23)(24)(25)(26)(27)(28). In A, population density increased 2.5-fold in the last three decades; in B, acute T. cruzi infections increased several-fold in the same timespan.…”

Section: Methodsmentioning

confidence: 99%

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Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Teixeira

Monteiro

Rebêlo

et al. 2001

Emerg. Infect. Dis.

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Section: Methodsmentioning

confidence: 99%

“…However, this enzootic protozoan infection received attention only after 1969, when acute cases of human Chagas disease were described in Belém, State of Pará, Brazil (22,23). Further evidence shows that T. cruzi infections are endemic in the Amazon Basin (12)(13)(14)(15)(21)(22)(23)(24)(25)(26)(27)(28) (Figures 1 and 2). …”

Section: Researchmentioning

confidence: 99%

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Teixeira

Monteiro

Rebêlo

et al. 2001

Emerg. Infect. Dis.

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Exposure to mixed asymptomatic infections with Trypanosoma cruzi, Leishmania braziliensis and Leishmania chagasi in the human population of the greater Amazon

Mendes

Lauria-Pires

Nitz

et al. 2007

Tropical Med Int Health

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SummaryLack of conservation of the Amazon tropical rainforest has imposed severe threats to its human population living in newly settled villages, resulting in outbreaks of some infectious diseases. We conducted a seroepidemiological survey of 1100 inhabitants of 15 villages of Paço do Lumiar County, Brazil. Thirty-five (3%) individuals had been exposed to Trypanosoma cruzi (Tc), 41 (4%) to Leishmania braziliensis (Lb) and 50 (4.5%) to Leishmania chagasi (Lc) infections. Also, 35 cases had antibodies that were cross-reactive against the heterologous kinetoplastid antigens. Amongst these, the Western blot assays revealed that 11 (1%) had Tc and Lb, that seven (0.6%) had Lc and Tc, and that 17 (1.6%) had Lb and Lc infections. All of these cases of exposures to mixed infections with Leishmania sp, and eight of 11 cases of Tc and Lb were confirmed by specific PCR assays and Southern hybridizations. Two cases had triple infections. We consider these asymptomatic cases showing phenotype and genotype markers consistent with mixed infections by two or more kinetoplastid flagellates a high risk factor for association with Psychodidae and Triatominae vectors blood feeding and transmitting these protozoa infections. This is the first publication showing human exposure to mixed asymptomatic kinetoplastid infections in the Amazon.

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Chagas' disease in the Brazilian Amazon: I - a short review

Coura

Junqueira

Giordano

et al. 1994

Rev. Inst. Med. trop. S. Paulo

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At least eighteen species of triatominae have been found in the Brazilian Amazon, nine of them naturally infected with Trypanosoma cruzi or "cruzi-like" trypanosomes and associated with numerous wild reservoirs. Despite the small number of human cases of Chagas' disease described to date in the Brazilian Amazon the risk that the disease will become endemic in this area is increasing for the following reasons: a) uncontrolled deforestation and colonization altering the ecological balance between reservoir hosts and wild vectors; b) the adaptation of reservoir hosts of T. cruzi and wild vectors to peripheral and intradomiciliary areas, as the sole feeding alternative; c) migration of infected human population from endemic areas, accompanied by domestic reservoir hosts (dogs and cats) or accidentally carrying in their baggage vectors already adapted to the domestic habitat. In short, risks that Chagas' disease will become endemic to the Amazon appear to be linked to the transposition of the wild cycle to the domestic cycle in that area or to transfer of the domestic cycle from endemic areas to the Amazon.

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Primeiros casos agudos autóctones da doença de Chagas no Maranhão e inquérito soro-epidemiológico da população

Cited by 6 publications

References 1 publication

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Emerging Chagas Disease: Trophic Network and Cycle of Transmission ofTrypanosoma cruzifrom Palm Trees in the Amazon

Exposure to mixed asymptomatic infections with Trypanosoma cruzi, Leishmania braziliensis and Leishmania chagasi in the human population of the greater Amazon

Chagas' disease in the Brazilian Amazon: I - a short review

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