Correlação sorológica eletrocardiográfica para a doença de Chagas em populações rurais não selecionadas do Rio Grande do Sul

Baruffa, Giovanni; Filho, Alcino Alcantara; Neto, José Ósimo de Aquino

doi:10.1590/s0037-86821983000300002

Cited by 5 publications

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“…Concerning place of residence, most T. cruzi seropositive donors lived in Pelotas, RS, an important endemic region for CD in the south of Brazil (Baruffa & Alcantara Filho, 1985). Regarding schooling, 75% of seropositive patients attended school for eight years, at most, a fact that shows the importance of schooling to implement preventive measures related to CD (Villela et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of anti-TRYPANOSOMA CRUZI and anti-TOXOPLASMA GONDII antibodies in possible and potential organ donors in the south of Rio Grande do Sul state, Brazil

et al. 2020

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Serological profiles are important in cases of solid organ donation where serological findings, such as antibodies against Trypanosoma cruzi and toxoplasmosis, may interfere in organ donation by increasing morbidity and mortality. This study aimed to outline seroprevalence of anti-Trypanosoma cruzi and anti-Toxoplasma gondii antibodies in possible and potential organ donors in the south of Rio Grande do Sul (RS) State, Brazil. A cross-sectional quantitative and retrospective epidemiological study was carried out, based on secondary data. Data on serology were extracted from medical records found in the Sistema de Gestão Hospitalar (SIGH), a hospital management system used by a university hospital in the south of RS, Brazil.Sociodemographic variables, such as age, sex and race, as well as clinical variables, such as titration of IgM and IgG anti-T. cruzi and anti–T. gondii antibodies, were analyzed. Medical records were found to be poorly filled in, since 67.6% (506 records) could not be used due to lack of information. Seroprevalence of T. cruzi was 6.8% (5 cases), mostly in white males. Regarding seroprevalence of T. gondii, 76.2% (64 donors) were serologicaly positive, 10.9% of which were IgM positive. This is the first study on anti-T. cruzi and anti-T. gondii antibodies inorgan donors in RS, Brazil and should be furthered since there may be consequences regarding organ uptake and donation.KEY WORDS: Epidemiological studies; Trypanosoma cruzi; Toxoplasma gondii; organ donation

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of anti-TRYPANOSOMA CRUZI and anti-TOXOPLASMA GONDII antibodies in possible and potential organ donors in the south of Rio Grande do Sul state, Brazil

et al. 2020

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“…O cálculo do odds ratio mostrou que os indivíduos com soro reagentes tiveram 1,70 (IC95%=1,27-2,28) vezes mais chance de terem alterações eletrocardiográficas quando comparados com os de soro não reagentes, havendo diferença estatisticamente significativa (p < 0,001) (Tabela 4). Estes dados contrastam com os achados de Brant 23 e Baruffa 43 , que não encontraram diferença significativa entre as prevalências de cardiopatia, estudando chagásicos e não-chagásicos no Rio Grande do Sul. Contrasta também com os achados das informações preliminares sobre o inquérito Nacional, onde Macêdo e colaboradores não encontraram diferença estatisticamente significativa entre os indivíduos soro reagentes e os não reagentes do Rio Grande do Sul (p = 0,18) 14 .…”

Section: Discussionunclassified

O inquérito eletrocardiográfico

Gonçalves

Prata

Dias

et al. 2011

Rev. Soc. Bras. Med. Trop.

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RESUMOEntre 1977 e 1981, foi realizado um inquérito eletrocardiográfico nacional tendo por objetivo avaliar a prevalência da cardiomiopatia chagásica no Brasil. Foram feitos 5.347 eletrocardiogramas. Após o pareamento dos indivíduos, segundo a idade e gênero, a distribuição dos eletrocardiogramas dos autóctones, em cada estado, ficou assim constituída: Rio Grande do Sul (1.078), Minas Gerais (760), Bahia (612), Paraná (400), Paraíba (340), Piauí (218), Sergipe (216), Goiás (176), Pernambuco (170), Ceará (136) e Alagoas (134). Os maiores percentuais de alterações eletrocardiográficas entre os indivíduos com soros reagentes foram encontrados nos Estados de Goiás (63,6%), Minas Gerais (57,6%), Ceará (57,3%), Paraná (54,5%), Piauí (53,2%) e Paraíba (52,3%). Entre os controles, nestes estados, a prevalência das alterações eletrocardiográficas foi de 25%, 25,7%, 25%, 12,5%, 22,9% e 26,5% respectivamente. Observou-se diferença estatisticamente significativa em relação à prevalência das alterações eletrocardiográficas, entre os indivíduos soro reagentes e os não reagentes, em todos os estados, exceção feita para o de Alagoas. O cálculo do gradiente mostrou-se maior no Estado do Paraná (42%), seguido por Goiás (38,6%), Ceará (32,3%) Minas Gerais (31,9%), Piauí (30,3%), Paraíba (25,8%), Pernambuco (22,3%), Bahia (18,9%), Sergipe (16,7%), Rio Grande do Sul (9,9%) e Alagoas (7,5%). Em relação à distribuição das alterações eletrocardiográficas encontradas, nos onze estados analisados, verificou-se que as extrassístoles ventriculares, o bloqueio de grau avançado do ramo direito, o bloqueio da divisão ântero-superior do ramo esquerdo, a associação do bloqueio de grau avançado do ramo direito com o bloqueio da divisão ântero-superior do ramo esquerdo e alterações primárias do segmento ST e da onda T, mostraram diferença estatisticamente significativa, entre os indivíduos com sororreagentes e os não reagentes Além disto, estas alterações eletrocardiográficas foram as de maior prevalência no grupo dos indivíduos chagásicos. Palavras-chaves: Doença de Chagas. Eletrocardiografia. Levantamentos epidemiológicos. ABSTRACTIn order to investigate the prevalence of chagasic heart disease in Brazil, a national electrocardiographic survey was carried out from 1977 to 1981. A total of 5,347 electrocardiograms (ECG) were performed and paired by age and gender. The results obtained in relation with the autochthonous cases, were distributed by Brazilian states, as follows: Rio Grande do Sul (1,078), Minas Gerais (760), Bahia (612), Paraná (400), Paraiba (340), Piauí (218), Sergipe (216), Goiás (176), Pernambuco (170), Ceará (136) and Alagoas 134. The higher proportions of altered ECGs among seropositive individuals were found in the States of Goiás (63.6%), Minas Gerais (57.6%), Ceará (57.3%), Paraná (54.5%), Piauí (53.2%) and Paraiba (52.3%). Among the control individuals, these proportions were respectively 25%, 25.7%, 25%, 12.5%, 22.9% and 26.5%. A significant statistical difference of altered ECGs between positive and negative individuals ...

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“…Other authors pointed out that the percentage of individuals with chagasic cardiopathy in endemic areas varied from 8% to 50%. [28][29][30][31][32][33][34] The frequency of the digestive form of this casuistry (6.3%) is included in that signalized in other endemic areas of Brazil, and it oscillates between 3% and 10% of the population living in these areas. 26,35 The differences in clinical form presentations have raised questions about the potential for evolving forms.…”

Section: Discussionmentioning

confidence: 99%

Familial Analysis of Seropositivity to Trypanosoma cruzi and of Clinical Forms of Chagas Disease

Silva-Grecco¹,

Balarin²,

Correia³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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Abstract.A cross-sectional study was carried out in Água Comprida, MG, Brazil, a region previously endemic to Chagas disease whose vectorial transmission was interrupted around 20 year ago. A total of 998 individuals were examined for anti-Trypanosoma cruzi antibodies. Seropositivity was observed in 255 subjects (25.5%), and 743 subjects were negative. Forty-one families with 5-80 individuals with similar environmental conditions were selected for familial analysis. In 15 families, seropositivity to T. cruzi was observed in > 50% of individuals. The segregation analysis confirmed family aggregation for the seropositivity to the T. cruzi . Heart commitment was the major clinical form observed, and in six families, > 50% of the individuals display cardiopathy that may be attributed to T. cruzi infection. Our results support the hypothesis that there is a family aggregation for the seropositivity but without the effect of one major gene.

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Correlação sorológica eletrocardiográfica para a doença de Chagas em populações rurais não selecionadas do Rio Grande do Sul

Cited by 5 publications

References 3 publications

Seroprevalence of anti-TRYPANOSOMA CRUZI and anti-TOXOPLASMA GONDII antibodies in possible and potential organ donors in the south of Rio Grande do Sul state, Brazil

Seroprevalence of anti-TRYPANOSOMA CRUZI and anti-TOXOPLASMA GONDII antibodies in possible and potential organ donors in the south of Rio Grande do Sul state, Brazil

O inquérito eletrocardiográfico

Familial Analysis of Seropositivity to Trypanosoma cruzi and of Clinical Forms of Chagas Disease

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