EVALUATION OF THE MOLLUSCICIDAL POTENTIAL OF HYDROALCOHOLIC EXTRACTS OF Jatropha gossypiifolia Linnaeus, 1753 ON Biomphalaria glabrata (Say, 1818)

Filho, Adalberto Alves Pereira; França, Clícia Rosane Costa; Oliveira, Dorlam's da Silva; Mendes, Renato; Gonçalves, José de Ribamar Santos; Rosa, Ivone Garros

doi:10.1590/s0036-46652014000600009

Cited by 23 publications

(17 citation statements)

References 18 publications

(20 reference statements)

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“…Phytochemical profile information not only facilitate the study of a plant material, but also direct research related to the use of this material for different purposes, such as the production of new drugs and antibiotics, contributing to the research of molluscicidal substances of plants 28 . In the phytochemical study carried out with E. umbellata latex the metabolites phenols, tannins, flavonoids, steroids, saponins and alkaloids were not detected.…”

Section: Resultsmentioning

confidence: 99%

Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Pereira

Dias

Miranda

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae). The aim of this study was to evaluate the chemical composition and molluscicidal activity of the latex produced by E. umbellata, as well as the safety of its application in aquatic environments. The concentration of latex that killed 90% of the exposed snails after 24 h exposure (LC90) was 3.69 mg/L. Toxicity bioassays using Danio rerio (zebrafish) revealed that these animals were less susceptible to latex than planorbids. However, it is important to perform other toxicity tests to ensure the feasibility of using latex to control populations of mollusks that contribute to schistosomiasis transmission. A phytochemical screening performed with the E. umbellata latex identified the triterpenoid and coumarin class. Further studies are warranted to isolate, identify, and test the active compounds of E. umbellata latex in B. glabrata.

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Section: Resultsmentioning

confidence: 99%

Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Pereira

Dias

Miranda

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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“…Pereira-Filho et al . 21 observed that the alimentary capacity of mollusks was totally suppressed when they were exposed to extract of J. gossypiifolia leaves. Lopes 38 also verified mollusks feeding inhibition when in contact with Caryocar brasiliense leaves.…”

Section: Discussionmentioning

confidence: 97%

“…Pereira-Filho et al . 21 in a study on the effect of Jatropha gossypiifolia leaves, obtained 100% of snails mortality at concentrations of 100 and 75 ppm after 24 h, and at concentrations of 50 and 25 ppm after 72 h. Lopes 38 verified a strong molluscicidal activity of C. brasiliense leaves extracts, obtaining 100% of B. glabrata mortality in 0.017 mg/mL after 24 h. The hydroalcoholic extract of Syzygium jambolanum stems also caused 100% snails lethality at 125 ppm concentration on the first day of exposure 42 .…”

Section: Discussionmentioning

confidence: 99%

“…Phytochemical analyses of the three species were performed based on methodologies described by Matos 20 and referenced by Pereira-Filho et al . 21 , using the following tests: identification of tannins, alkaloids, coumarins, steroids and triterpenoids and saponins. Concentrations of the compounds are described using crosses, where (+++) means strongly positive, (++) moderately positive, (+) weakly positive, (-) traces and (0) undetected.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of molluscicidal activity of three mangrove species (Avicennia schaueriana, Laguncularia racemosa and Rhizophora mangle) and their effects on the bioactivity of Biomphalaria glabrata Say, 1818

Mendes

Filho

Nogueira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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Schistosomiasis is a disease of global extent reaching populations in social vulnerability. One of the control measures of this parasitosis is the use of molluscicidal substances that can fight snails of the genus Biomphalaria, intermediate hosts of Schistosoma mansoni. The aim of this work was to study the toxic activity of three mangrove species (Avicennia schaueriana Stapf. & Leech, ex Moldenke, 1939, Laguncularia racemosa (L.) CF Gaertn, 1807 and Rhizophora mangle L. 1753) on the biological activities of snails Biomphalaria glabrata. Hydroalcoholic extracts were prepared from the stem and leaves of each of the three plant species to which mollusks were exposed. The phytochemical analysis of plants showed the presence of important metabolites in the leaves and stems of L. racemosa and R. mangle, such as tannins and saponins, but the absence of these metabolites in A. schaueriana. Leaf and stem extracts of the three plant species showed low molluscicidal activity, not reaching the standards determined by the World Health Organization (WHO, 1983). L. racemosa and R. mangle has interfered with motility, feeding and oviposition of snails, unlike the extracts of A. schaueriana, which had no effect on these activities.

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“…Others plant extracts also display molluscicidal activities at concentrations lower that the one required by the WHO. Alcoholic stem extract from Jatropha gossypiifolia shows toxicity towards adult snails after 24 h exposure with a LC 50 of 25 ppm [ 51 ]. Chlorophyllin extracted from Moringa oleifera leaves has a lethal activity on adults Biomphalaria snails exposed during 24 h probably by interfering with nervous and digestive systems [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact

et al. 2020

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Background Freshwater snails are the intermediate hosts of a large variety of trematode flukes such as Schistosoma mansoni responsible for one of the most important parasitic diseases caused by helminths, affecting 67 million people worldwide. Recently, the WHO Global Vector Control Response 2017–2030 (GVCR) programme reinforced its message for safer molluscicides as part of required strategies to strengthen vector control worldwide. Here, we present the essential oil from Eryngium triquetrum as a powerful product with molluscicide and parasiticide effect against S. mansoni and the snail intermediate host Biomphalaria glabrata. Methods In the present study, we describe using several experimental approaches, the chemical composition of E. triquetrum essential oil extract and its biological effects against the snail B. glabrata and its parasite S. mansoni. Vector and the free-swimming larval stages of the parasite were exposed to different oil concentrations to determine the lethal concentration required to produce a mortality of 50% (LC50) and 90% (LC90). In addition, toxic activity of this essential oil was analyzed against embryos of B. glabrata snails by monitoring egg hatching and snail development. Also, short-time exposure to sublethal molluscicide concentrations on S. mansoni miracidia was performed to test a potential effect on parasite infectivity on snails. Mortality of miracidia and cercariae of S. mansoni is complete for 5, 1 and 0.5 ppm of oil extract after 1 and 4 h exposure. Results The major chemical component found in E. triquetrum oil determined by GC-FID and GC/MS analyses is an aliphatic polyacetylene molecule, the falcarinol with 86.9–93.1% of the total composition. The LC50 and LC90 values for uninfected snails were 0.61 and 1.02 ppm respectively for 24 h exposure. At 0.5 ppm, the essential oil was two times more toxic to parasitized snails with a mortality rate of 88.8 ± 4.8%. Moderate embryonic lethal effects were observed at the concentration of 1 ppm. Severe surface damage in miracidia was observed with a general loss of cilia that probably cause their immobility. Miracidia exposed 30 min to low concentration of plant extract (0.1 ppm) were less infective with 3.3% of prevalence compare to untreated with a prevalence of 44%. Conclusions Essential oil extracted from E. triquetrum and falcarinol must be considered as a promising product for the development of new interventions for schistosomiasis control and could proceed to be tested on Phase II according to the WHO requirements.

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EVALUATION OF THE MOLLUSCICIDAL POTENTIAL OF HYDROALCOHOLIC EXTRACTS OF Jatropha gossypiifolia Linnaeus, 1753 ON Biomphalaria glabrata (Say, 1818)

Cited by 23 publications

References 18 publications

Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Evaluation of molluscicidal activity of three mangrove species (Avicennia schaueriana, Laguncularia racemosa and Rhizophora mangle) and their effects on the bioactivity of Biomphalaria glabrata Say, 1818

Molluscicidal and parasiticidal activities of Eryngium triquetrum essential oil on Schistosoma mansoni and its intermediate snail host Biomphalaria glabrata, a double impact

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