Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin

Parise, Edison Roberto; Oliveira, Ana Cláudia de; Ferraz, Maria Lúcia Gomes; Pereira, Aparecido B.; Leite, Kátia Ramos Moreira

doi:10.1590/s0036-46652007000200001

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…Parise et al . reported that serum HCV RNA and HCV genotype did not have any association with cryoglobulinemia in CHC patients . However, we found that lower HCV RNA was associated with cryoglobulinemia but not HCV genotype 1.…”

Section: Discussioncontrasting

confidence: 75%

Association between cryoglobulinemia and liver fibrosis in chronic hepatitis C patients

Batsaikhan

Huang

Yeh

et al. 2018

J of Gastro and Hepatol

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Section: Discussioncontrasting

confidence: 75%

Association between cryoglobulinemia and liver fibrosis in chronic hepatitis C patients

Batsaikhan

Huang

Yeh

et al. 2018

J of Gastro and Hepatol

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“…The association between cryoglobulins and a specific genotype varies from one region to another and results from an interaction betwen viral and host factors. The high frequency of cryoglobulins in patients with genotype 3 infection observed in our study could have resulted from hight frequency of cirrhosis associated with this genotype, since crioglobulinemia may represent a complication in patients with HCV infection, especially in those with cirrhosis [ 16 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative study of patients with chronic hepatitis C virus infection due to genotypes 1 and 3 referred for treatment in southeast Brazil

et al. 2008

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Background: The progression of liver disease in patients with chronic hepatitis C virus (HCV) infection is influenced by host and viral factors. Distinct clinical outcomes in patients infected with different HCV genotypes have been described in the literatute. However, the association between specific HCV genotype and clinical outcome remains unclear. We set out to study the natural history of HCV genotype 1 and 3 infections in Campinas, São Paulo state, Brazil, focusing on epidemiological, clinical, biochemical, and histological characteristics.

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“…В других исследованиях определена связь КГЕ с женским полом, не первым генотипом вируса, низкой вирусной нагрузкой и низким уровнем тромбоцитов [13], длительностью ВГC-инфекции [14], более высокой стадией фиброза и циррозом печени [15]. В отдельных исследованиях не было обнаружено взаимосвязи между КГЕ, уровнем РНК ВГC и генотипом вируса [16].…”

Section: Discussionunclassified

Hepatitis C Infections with Cryoglobulinemia: Features and Symptoms

Лукашик¹,

Karpov²,

Krasko³

2021

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Study Objective: To study the incidence of cryoglobulinemia (CGE) in chronic hepatitis C infection (hepatitis C infection) and to analyse the characteristics of chronic hepatitis C infection with CGE in Belarusian patients. Study Design: Open non-randomised observational study. Materials and Methods. The study included 773 patients with chronic hepatitis C infection (in Minsk). The patients had their anti-hepatitis C antibodies, chronic hepatitis C RNA and virus genotype measured; blood cryoglobulins identified; demographic and epidemiological data collected; and complete blood assay and biochemical blood assay performed. Study Results. 282 (36.5%) subjects had positive blood cryoglobulins test, while 491 (63.5%) patients had negative result. CGE and non-CGE groups had comparable sex, BMI and infection duration parameters. CGE patients had statistically more surgeries (р < 0.001), clinical syndromes (including asthenovegetative, arthralgic and dyspeptic syndromes, р < 0.001 in all cases), hepatic fibrosis F3 (р < 0.05), hepatic cirrhosis (р < 0.001), and extrahepatic diseases (EHDs); more often they had genotype 3 of hepatitis C infection (р < 0.05) and low replicative activity of the virus (р < 0.05). Conclusion. The incidence of CGE in the study population made 36.5%. CGE patients had more pronounced hepatic process chronization, frequenter EHDs, more genotype 3 cases, and lower replicative activity of the virus. Keywords: hepatitis С, hepatic cirrhosis, cryoglobulinemia, extrahepatic diseases.

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Cryoglobulinemia in chronic hepatitis C: clinical aspects and response to treatment with interferon alpha and ribavirin

Abstract: MC represents a prevalent complication in patients with CHC, specially older and cirrhotic patients. Only 24% of these patients show clinical manifestation of the disease, specially those with type II MC. The presence of MC did not affect the response to therapy.

Cited by 10 publications

References 30 publications

Association between cryoglobulinemia and liver fibrosis in chronic hepatitis C patients

Association between cryoglobulinemia and liver fibrosis in chronic hepatitis C patients

Comparative study of patients with chronic hepatitis C virus infection due to genotypes 1 and 3 referred for treatment in southeast Brazil

Hepatitis C Infections with Cryoglobulinemia: Features and Symptoms

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