Paracoccidioidomycosis in organ transplant recipient: case report

Zavascki, Alexandre Prehn; Bienardt, João Carlos; Severo, Luiz Carlos

doi:10.1590/s0036-46652004000500009

Cited by 38 publications

(27 citation statements)

References 5 publications

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“…In a small number of cases, PCM manifested a few days to 14 years after kidney transplantation, which enabled the evaluation of PCM's clinical and laboratory characteristics under these conditions. Chest X-rays revealed that these patients had bilateral nodules 18 , pulmonary cavitation 71,72 , or bronchopneumonic infiltrate 73 . Lymphatic impairment was uncommon 74 .…”

Section: Organ Transplantation and Immunosuppressive Therapymentioning

confidence: 95%

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Shikanai-Yasuda

Mendes

Colombo

et al. 2017

Rev. Soc. Bras. Med. Trop.

322

590

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Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis (P. brasiliensis) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii (P. lutzii), has been reported in Rondônia, where the disease has reached epidemic levels, and in the Central West and Pará. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.

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Section: Organ Transplantation and Immunosuppressive Therapymentioning

confidence: 95%

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Shikanai-Yasuda

Mendes

Colombo

et al. 2017

Rev. Soc. Bras. Med. Trop.

322

590

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“…Only three cases of paracoccidioidomycosis in SOT recipients have been reported, and all occurred in renal transplant patients (339,353,417). In all cases, infection developed more than 5 years after transplantation, and clinical presentations were similar to those of other cases of this mycosis in nonimmunosuppressed patients.…”

Section: Other Regional Fungal Infectionsmentioning

confidence: 82%

“…In all cases, infection developed more than 5 years after transplantation, and clinical presentations were similar to those of other cases of this mycosis in nonimmunosuppressed patients. Exceptionally, one patient was found to have cavitating lung lesions, which is infrequent in immunocompetent patients (417).…”

Section: Other Regional Fungal Infectionsmentioning

confidence: 95%

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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“…P. brasiliensis is a thermally dimorphic fungus that typically infects healthy adults. Infection primarily involves the lungs and then disseminates to other organs 5 . Paracoccidioidomycosis is very rare in transplanted patients and a limited number of reports have been described in kidney transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Paracoccidioidomycosis in a liver transplant recipient

Lima

Bezerra

Siqueira

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Paracoccidioidomycosis is a granulomatous systemic mycosis that is endemic in Latin America; it is an extremely rare infection following solid organ transplantation. In this study, we describe the first report of disseminated paracoccidioidomycosis in a 3-year-old girl who underwent liver transplantation 2 years previously. The radiologic diagnosis and patient follow-up are described. In addition, we review the clinical evolution and treatment regimens for this infection.

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Paracoccidioidomycosis in organ transplant recipient: case report

Cited by 38 publications

References 5 publications

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Brazilian guidelines for the clinical management of paracoccidioidomycosis

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Paracoccidioidomycosis in a liver transplant recipient

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