Candidemia in a Brazilian tertiary care hospital: species distribution and antifungal susceptibility patterns

Antunes, Ana Graciela Ventura; Pasqualotto, Alessandro C.; Díaz, María Cristina; d’Azevedo, Pedro Alves; Severo, Luiz Carlos

doi:10.1590/s0036-46652004000500001

Cited by 54 publications

(28 citation statements)

References 11 publications

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“…Although there are some large studies published in this field, most of the data on candidemia in Spain are limited to retrospective reviews of medical records or observational studies conducted in a limited number of medical centers (4,9,10,39). Consequently, the incidence of candidemia in tertiary care hospitals in Spain is largely unknown, and no reliable national data are available.…”

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confidence: 99%

Nationwide Sentinel Surveillance of Bloodstream Candida Infections in 40 Tertiary Care Hospitals in Spain

et al. 2010

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Candidemia studies have documented geographic differences in rates and epidemiology, underscoring the need for surveillance to monitor trends. We conducted prospective candidemia surveillance in Spain to assess the incidence, species distribution, frequency of antifungal resistance, and risk factors for acquiring a Candida infection. Prospective laboratory-based surveillance was conducted from June 2008 to June 2009 in 40 medical centers located around the country. A case of candidemia was defined as the isolation of a Candida species from a blood culture. Incidence rates were calculated per 1,000 admissions. Antifungal susceptibility tests were performed by using broth microdilution assay according to the guidelines of the Clinical and Laboratory Standards Institute. We detected 984 cases, for an overall incidence of 1.09 cases per 1,000 admissions. The crude mortality was 20.20%. Candida albicans was the most common species (49.08%), followed by C. parapsilosis (20.73%), C. glabrata (13.61%), and C. tropicalis (10.77%). Overall, decreased susceptibility to fluconazole occurred in 69 (7.01%) incident isolates. Antifungal resistance was rare, and a moderate linear correlation between fluconazole and voriconazole MICs was observed. This is the largest multicenter candidemia study conducted to date and shows the substantial morbidity and mortality of candidemia in Spain.

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confidence: 99%

Nationwide Sentinel Surveillance of Bloodstream Candida Infections in 40 Tertiary Care Hospitals in Spain

et al. 2010

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“…In addition, it provides the most representative and consistent data from South America on the epidemiology of candidemia to date (5,11,12,39).…”

Section: Discussionmentioning

confidence: 96%

“…Data on candidemia in this region are limited to retrospective reviews of medical records or observational studies conducted in a limited number of medical centers (5,11,12,46). Consequently, the incidence of candidemia in tertiary-care hospitals in Brazil is largely unknown, and no national data are available.…”

mentioning

confidence: 99%

Epidemiology of Candidemia in Brazil: a Nationwide Sentinel Surveillance of Candidemia in Eleven Medical Centers

et al. 2006

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Candidemia studies have documented geographic differences in rates and epidemiology, underscoring the need for surveillance to monitor trends. We conducted prospective candidemia surveillance in Brazil to assess the incidence, species distribution, frequency of antifungal resistance, and risk factors for fluconazole-resistant Candida species. Prospective laboratory-based surveillance was conducted from March 2003 to December 2004 in 11 medical centers located in 9 major Brazilian cities. A case of candidemia was defined as the isolation of Candida spp. from a blood culture. Incidence rates were calculated per 1,000 admissions and 1,000 patientdays. Antifungal susceptibility tests were performed by using the broth microdilution assay, according to the Clinical and Laboratory Standards Institute guidelines. We detected 712 cases, for an overall incidence of 2.49 cases per 1,000 admissions and 0.37 cases per 1,000 patient-days. The 30-day crude mortality was 54%. C. albicans was the most common species (40.9%), followed by C. tropicalis (20.9%) and C. parapsilosis (20.5%). Overall, decreased susceptibility to fluconazole occurred in 33 (5%) of incident isolates, 6 (1%) of which were resistant. There was a linear correlation between fluconazole and voriconazole MICs (r ‫؍‬ 0.54 and P < 0.001 [Spearman's rho]). This is the largest multicenter candidemia study conducted in Latin America and shows the substantial morbidity and mortality of candidemia in Brazil. Antifungal resistance was rare, but correlation between fluconazole and voriconazole MICs suggests cross-resistance may occur.

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“…All participants freely signed informed consent forms, and their identities were kept secret. Data obtained in the survey were contrasted with the Infectious Diseases Society of America's (IDSA) recommendations for the treatment of candidemia 3 , and also with previously published epidemiological data from the participating centers 1,2,[5][6][7] .Statistical analyses were performed using SPSS version 16.0 for Windows. Categorical variables were compared using chi-squared or Fisher's exact tests, wherever appropriate.…”

Section: Methodsmentioning

confidence: 99%

Invasive candidosis: contrasting the perceptions of infectious disease physicians and intensive care physicians

Schultz

Colombo

Pasqualotto

2013

Rev. Soc. Bras. Med. Trop.

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Candidemia in a Brazilian tertiary care hospital: species distribution and antifungal susceptibility patterns

Cited by 54 publications

References 11 publications

Nationwide Sentinel Surveillance of Bloodstream Candida Infections in 40 Tertiary Care Hospitals in Spain

Nationwide Sentinel Surveillance of Bloodstream Candida Infections in 40 Tertiary Care Hospitals in Spain

Epidemiology of Candidemia in Brazil: a Nationwide Sentinel Surveillance of Candidemia in Eleven Medical Centers

Invasive candidosis: contrasting the perceptions of infectious disease physicians and intensive care physicians

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