“…However, pentamidine and amphotericin B have shown a high toxicity at the effective therapeutic doses (Maddux & Barriere, 1980;Soto-Mancipe et al, 1994). Resistance to treatment with antimonybased agents occurs frequently, and resistance to other drugs like pentamidine or amphotericin B was mentioned (Sereno et al, 1997;Durand et al, 1998;Lira et al, 1999;Thakur et al, 2001;Basselin et al, 2002;Khan et al, 2002;Coelho et al, 2004). So, no drug is totally active and safe.…”