Isolation of Fonsecaea pedrosoi from thorns of Mimosa pudica, a probable natural source of chromoblastomycosis

Salgado, Cláudio Guedes; Silva, Jorge Pereira da; Diniz, José Antônio Picanço; Silva, Moisés Batista da; Costa, Patrícia; Teixeira, Cláudio Mello; Salgado, Ubirajara Imbiriba

doi:10.1590/s0036-46652004000100006

Cited by 77 publications

(54 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In nature, monoaromates are found in trace amounts in plant debris, thorns, and wood cortex, which provide microhabitats for these fungi (74). There is a strong correlation between the traumatic implantation of potential natural sources of infection and CBM lesions (74)(75)(76)(77)(78)(79)(80). This route of infection may be supported by clinical reports of patients exhibiting the presence of fragments of plant material at the site where they experienced a previous trauma.…”

Section: Epidemiology Potential Environmental Sources Of Infectionmentioning

confidence: 92%

Chromoblastomycosis

et al. 2017

Self Cite

View full text Add to dashboard Cite

SUMMARY Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

show abstract

Section: Epidemiology Potential Environmental Sources Of Infectionmentioning

confidence: 92%

Chromoblastomycosis

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, special isolation techniques may be necessary. Previous authors have successfully implemented methods using experimental inoculations in laboratory animals (Gezuele et al 1972;Dixon et al 1980), high incubation temperatures (Sudhadham et al 2008), extraction with mineral oil (Satow et al 2008;Vicente et al 2008), enrichment on atmospheres with aromatic hydrocarbons (Prenafeta-Boldú et al 2001;Zhao et al 2010) and media containing cycloheximide (Salgado et al 2004). In our experience, media with cycloheximide proved to be very useful to isolate members of the Chaetothyriales.…”

Section: Introductionmentioning

confidence: 99%

New and interesting chaetothyrialean fungi from Spain

et al. 2016

View full text Add to dashboard Cite

In the course of taxonomic studies on saprobic microfungi from Spain, several slow-growing, dematiaceous hyphomycetes were isolated from soil, submerged plant material and river sediments. Sixteen of these strains were identified as members of the ascomycete order Chaetothyriales on the basis of morphology and DNA sequence analyses of the internal transcribed spacer region and partial large subunit ribosomal RNA gene. These included three novel species (Cladophialophora pseudocarrionii, Cyphellophora chlamydospora, and Rhinocladiella amoena) and five interesting, little-known or clinically-relevant species (Cyphellophora suttonii, Exophiala aquamarina, E. lacus, E. radicis, and Rhinocladiella similis). In addition, Exophiala oligosperma, an emerging opportunistic fungus, was found for the first time in an aquatic freshwater environment (river sediments). Cladophialophora pseudocarrionii resembles C. carrionii in the branching pattern of its conidial chains, but differs from the latter species in its inability to grow at 30 °C. Cyphellophora chlamydospora differs from other species of the genus in the absence of conidiation, producing only chlamydospores in vitro. Rhinocladiella amoena shows branched conidiophores similar to those of R. anceps, R. atrovirens, R. basitona and R. similis, but differs from them in conidial shape and size. The ex-type strain of Phialophora livistonae, included in the phylogenetic study, clustered with high statistical support with members of the genus Cyphellophora and is transferred to this genus.

show abstract

“…In 2004, we demonstrated the presence of F. pedrosoi hyphae and conidia responsible for disease in one patient on the thorns of Mimosa pudica. 21 We subsequently observed sclerotic cells, which are very similar to lesional cells, inside M. pudica thorns (Fig. 1).…”

mentioning

confidence: 63%