Thiamphenicol in the treatment of chancroid. A study of 1,128 cases

Abstract

Thiamphenicol, an aminic derivate of hydrocarbilsulfonil propandiol, was used for the treatment of 1,171 chancroid bearing patients. Each patient was medicated with 5.0 g of granulated thiamphenicol, orally, in a single dose, and was reevaluated 3, 7 and 10 days after the treatment. Ten patients (0.89%) did not respond to the proposed treatment. 133 patients presented healed ulcers after 3 days of treatment, 976 patients healed chancres on the seventh day after the treatment, and 39 patients took 10 days to present healed chancres. The results of this study indicate that the rate of patients that were cured, the low incidence of side effects, and the practicality of administration make of thiamphenicol an excellent choice for the treatment of chancroid.

Chancroid: contemporary appraisal

“…3). The lymph glands are tender, swollen and matted together to ultimately form unilocular fluctuant swelling 1–17 . Its spontaneous rupture may result in a single discharging sinus in the inguinal region (Fig.…”

“…Chancroid, one of the classical genito‐ulcerative diseases (GUDs), has generated considerable interest across the globe, 1–10 especially in the light of the emerging drug resistant 11–15 and acquired immunodeficiency syndrome (AIDS) 15,16 . Hemophilus ducreyi is its causative bacterial agent.…”