Auricular chromoblastomycosis: case report

Bittencourt, Achiléa Candida Lisboa; Londero, A. T.; Andrade, José Célio Silveira

doi:10.1590/s0036-46651994000400014

Cited by 14 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Bangladesh case recalled a trauma with a knife, while a Vietnamese case in Japan recalled an injury with scrap wood, suggesting ubiquitous presence of the agent in the environment. A total of seven cases of auricular chromoblastomycosis including the present one have been reported in the literature, all occurring in male patients . Fonsecaea spp.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

A case of chromoblastomycosis by Fonsecaea nubica indicating a possible insect route of transmission

Chen

Yin

et al. 2016

Mycoses

View full text Add to dashboard Cite

A first auricular case of chromoblastomycosis due to Fonsecaea nubica is reported in a 42-year-old Chinese male. He presented a slightly verrucous, erythematous plaque on his right auricle which had gradually extended over a 10-year period, and the patient reported a history of dog flea sting before onset of the lesions. Diagnosis was based on histopathological and mycological examination of clinical samples, which revealed muriform cells. Identification of the aetiological agent was assessed by morphological characteristics and confirmed at species level by sequencing of the rDNA internal transcribed spacer (ITS). The patient showed marked clinical improvement after 3 months combination therapy with itraconazole and terbinafine. The possible mode of transmission of auricular chromoblastomycosis is discussed.

show abstract

Section: Discussionmentioning

confidence: 97%

“…A total of seven cases of auricular chromoblastomycosis including the present one have been reported in the literature, all occurring in male patients. [11][12][13][14][15][16] Fonsecaea spp. were the most frequent, found in five cases, while Rhinocladiella aquaspersa and Phialophora verrucosa each were encountered in a single case.…”

Section: Discussionmentioning

confidence: 99%

A case of chromoblastomycosis by Fonsecaea nubica indicating a possible insect route of transmission

Chen

Yin

et al. 2016

Mycoses

View full text Add to dashboard Cite

show abstract

“…Lesions in the upper and lower limbs are the most frequent symptom in CBM patients, and these are the body parts that are usually in contact with soil and plant debris. However, some patients have unusual lesions on the face, cornea, brain, chest, and abdomen [10,[18][19][20][21]. Recently, a case of chronic fungal meningitis caused by F. pedrosoi was reported in a patient from an endemic region for tuberculosis in India [22], demonstrating the high virulence capacity of this fungus to cause human disease.…”

Section: Epidemiologymentioning

confidence: 99%

Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis

Breda

Menezes

Paulo

et al. 2020

JoF

View full text Add to dashboard Cite

Chromoblastomycosis (CBM) is a neglected, chronic, and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family. CBM disease is usually associated with agricultural activities, and its infection is characterized by verrucous, erythematous papules, and atrophic lesions on the upper and lower limbs, leading to social stigma and impacts on patients’ welfare. The economic aspect of disease treatment is another relevant issue. There is no specific treatment for CBM, and different anti-fungal drug associations are used to treat the patients. However, the long period of the disease and the high cost of the treatment lead to treatment interruption and, consequently, relapse of the disease. In previous years, great progress had been made in the comprehension of the CBM pathophysiology. In this review, we discuss the differences in the cell wall composition of conidia, hyphae, and muriform cells, with a particular focus on the activation of the host immune response. We also highlight the importance of studies about the host skin immunology in CBM. Finally, we explore different immunotherapeutic studies, highlighting the importance of these approaches for future treatment strategies for CBM.

show abstract

Inhibition of Nitric Oxide Production by Macrophages in Chromoblastomycosis: A Role for Fonsecaea pedrosoi Melanin

et al. 2006

View full text Add to dashboard Cite

Chromoblastomycosis is a chronic and progressive deep mycosis that is usually found in tropical and subtropical areas. Fonsecaea pedrosoi is considered its most frequent etiologic agent and causes a typical granulomatous inflammatory response, whose degree reflects the immune status of the host. Since macrophages play a fundamental role in the control of the infection, this study aimed at investigating the production of oxygen reactive specimens, the phagocytic capacity and the production of nitric oxide (NO) by macrophages employing in vitro assays and an in vivo model of chromoblastomycosis. Our results demonstrated that, during the infection, peritoneal macrophages show an increased phagocytic capacity and H2O2 production, but also a reduced ability to produce NO. Moreover, F. pedrosoi stimulated H2O2 production in vitro but not the synthesis of NO. The incubation of IFNgamma and LPS-stimulated macrophages with melanin, obtained from the fungus, inhibited NO production. Examination of the liver and spleen of infected animals, at day 30 or 60 following inoculation, showed a progressive increase in the number and size of granulomas, indicating that macrophages are properly mobilized and activated. Our data suggest that the inability of the host to clear F. pedrosoi, leading to a chronic disease, is due, at least in part, to the inhibition of NO synthesis by macrophages by fungus-produced melanin.

show abstract

Auricular chromoblastomycosis: case report

Cited by 14 publications

References 7 publications

A case of chromoblastomycosis by Fonsecaea nubica indicating a possible insect route of transmission

A case of chromoblastomycosis by Fonsecaea nubica indicating a possible insect route of transmission

Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis

Inhibition of Nitric Oxide Production by Macrophages in Chromoblastomycosis: A Role for Fonsecaea pedrosoi Melanin

Contact Info

Product

Resources

About