Esporotricose do gato doméstico (Felis catus): transmissão humana

Marques, Sílvio Alencar; Franco, Selma Lucy; Camargo, Rubens de Figueiredo; Dias, Luiza Cristina Godim Domingues; Júnior, Vidal Haddad; Fabris, Viciany Erique

doi:10.1590/s0036-46651993000400004

Cited by 39 publications

(47 citation statements)

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“…O padrão com predomí-nio de macrófagos estava associado com uma carga fúngica alta e o padrão com predomínio de células epitelioides estava associado com uma carga fúngica baixa. Essa observação deve ser ressaltada, pois em grande parte da literatura veterinária somente o padrão inflamatório macrofágico associado à alta carga fúngica é mencionado na esporotricose felina (Marques et al 1993, Ginn et al 2007, Antunes et al 2009). Porém, o patologista deve estar alerta para a ocorrência de um padrão com predomínio de células epitelioides e uma carga fúngica bastante baixa, a qual muitas vezes é melhor detectada por meio de técnicas histoquímicas adicionais à coloração de HE.…”

Section: Discussionunclassified

Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

et al. 2016

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RESUMO.-Esporotricose é uma infecção fúngica causada por espécies do complexo Sporothrix, vista com maior frequência em gatos, equinos e cães. Os principais objetivos deste estudo retrospectivo foram caracterizar os aspectos histomorfológicos e histoquímicos da esporotricose em 10 gatos, além de avaliar os aspectos epidemiológicos, clíni-cos e os achados macroscópicos desses 10 casos, obtidos dos protocolos de biópsias e necropsias dos arquivos do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria. A doença acometeu predominantemente gatos machos, sem raça definida e apresentou-se principalmente na forma cutânea disseminada. As lesões macroscópicas caracterizaram-se como nódulos cutâneos (ulcerados ou não) e como massas e placas ulceradas. Na histopatologia observou-se uma relação entre a quantidade de leveduras observada e dois padrões de resposta infla- glaukommers@yahoo.com Sporotrichosis is a mycotic infection caused by the Sporothrix complex species, affecting mostly cats, horses, and dogs. The main objectives of this retrospective study were to characterize the histomorphological and histochemical aspects of sporotrichosis in 10 cats, and also to evaluate epidemiological and clinical aspects, and gross findings obtained from the biopsy and necropsy protocols of these ten cases, obtained from the archives of the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria. The disease affected mostly male mongrel cats, and was mostly observed in the cutaneous disseminated form. Gross lesions were characterized by cutaneous nodules (ulcerated or not) and by ulcerated masses or plaques. By histopathology, there were a relationship between the fungal load and two patterns of inflammatory response. The first pattern was characterized by high fungal load, and most yeasts were inside of numerous macrophages with abundant, many times vacuolated cytoplasm. The amount of neutrophils ranged from mild to moderate in this pattern. The second pattern was characterized by numerous epiteliod cells and many neutrophils. The fungal load was low and most yeasts were observed in the extracellular space. The yeasts were round, oval or cigar-shaped. Several histochemical techniques, such as Grocott's silver stain, periodic Schiff acid, and Alcian blue were utilized and they made it easier to visualize, to characterize the morphology, and to quantify the organisms. The Giemsa stain allowed visualizing the agent, but it not allowed to sharply highlight them from other intralesional components. Organisms were negative for melanin granules through the Fontana-Masson stain in all cases. The histomorphological and histochemical study allowed demonstrating determinant fungal characteristics to the establishment of the diagnosis by means of this diagnostic tool.INDEX TERMS: Feline sporotrichosis, Sporothrix spp. complex, diseases of cats, subcutaneous mycosis.

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Section: Discussionunclassified

Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

et al. 2016

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“…Sporotrichosis is caused by the dimorphic fungus, Sporothrix schenckii. There have been many reports of infections in horses, cats and humans [2,5,7]. Sporothrix schenckii is isolated from soils, sphagnum moss and tree bark.…”

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confidence: 99%

A Case of Feline Sporotrichosis

Hirano

Watanabe

Murakami

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. We excised surgically a feline granulomatous lesion and performed histopathological, mycological and molecular examinations. As a result, it was diagnosed as sporotrichosis, which was the second recorded case of a cat so afflicted in Japan. After the operation, we recognized another nodule on the lymph node. Histopathological examination was therefore performed, but no fungi were detected. To prevent recurrence, the cat was administered a antimycotic drug, itraconazole. As a result, no recurrence was found. Excision of the lesion is the treatment of choice for feline sporotrichosis. KEY WORDS: feline, itraconazole, sporotrichosis.J. Vet. Med. Sci. 68(3): 283-284, 2006 Fungi are widespread in the environment and not usually harmful to healthy animals. However, the number of mycosis cases has recently increased in animals in which the immunity has been decreased by antineoplastic drugs or immunosuppressive drugs. A report has indicated the zoonotic potential of some animal fungi around the world [9]. Sporotrichosis is caused by the dimorphic fungus, Sporothrix schenckii. There have been many reports of infections in horses, cats and humans [2,5,7]. Sporothrix schenckii is isolated from soils, sphagnum moss and tree bark. It infects animals and humans through a puncture wound. Sporotrichosis can be divided into three clinical forms: cutaneolymphatic, cutaneous, and disseminated [3]. In Japan there have been many cases of sporotrichosis in humans, but only one case report of feline sporotrichosis [8].This case was a 2-year-old male mongrel house cat with free outdoor access, weighing 5.4 kg, which had been treated for skin abscesses. This cat was referred to Gifu University Teaching Animal Hospital with a subcutaneous nodule on the right hind leg, which had gradual growth. The cat was in good general condition. A nodule was recognized near the main pad on the right hind leg. We excised it surgically under general anesthesia. The nodule, 18 × 15 × 6 mm in size, was brown and smooth, and was well-demarcated (Fig. 1). The histopathological finding indicated many yeast-like cells with granulomatous inflammation (Fig. 2), so culture and molecular examinations were performed for the biopsy material from the nodule. As a result, the isolate was identified as S. schenckii. And the case was diagnosed as sporotrichosis by S. schenckii-specific polymerase chain reaction analyses, too [6].Nine days after the operation, we recognized another nodule on the right popliteal lymph node. We excised it surgically, but no fungi were detected in it. According to the diagnosis of sporotrichosis, 34 days after the operation, the cat was administered itraconazole (15 mg/kg once daily, per os) to avoid recurrences. After 50 postoperative days, we also recognized another nodule on the left popliteal lymph node, and performed a fine needle aspiration biopsy because there was a possibility of metastasis. However it was not diagnosed. At 69 days postoperation, the left popliteal lymph node showed a slight decrease in size, but the ...

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“…However, Barros and collaborators identified the presence of fungal elements in 28.8% of the histopathological examinations and formulated the hypothesis that this high percentage could be related to the zoonotic transmission, what can be corroborated by the exuberance of fungal elements found in cutaneous lesions of infected cats. 2,8,9 There are many treatment modalities for sporotrichosis, from exposure to heat to the use of saturated solution of potassium iodide and antifungal like itraconazole, but according to the medical literature the success rates are variable.…”

Section: Discussionmentioning

confidence: 99%

Ocorrência familiar de esporotricose zoonótica

Cordeiro

Bruno

Paula

et al. 2011

An. Bras. Dermatol.

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Abstract:Sporotrichosis is a suba cu te or chro nic myco sis cau sed by the dimor phic fun gus Sporothrix schenc kii which is ende mic in Brazil and is trans mit ted pri ma rily through trau ma tic ino cu la tion of its causa ti ve agent into the skin. The zoo no tic trans mis sion, espe cially from infec ted cats, has been demons trated in seve ral reports and case series. We pre sent simul ta neous occur ren ce of the disea se in three members of the same family by scrat ches from an infec ted domes tic cat. Two patients deve lo ped the lympho cuta neous form and one only deve lo ped the fixed cuta neous form. Two patients were suc cess fully trea ted with satu ra ted solu tion of potas sium iodi de; howe ver, the third case repor ted side effects and had his therapy subs ti tu ted for itra co na zo le, with reso lu tion of his lesions. Keywords: Cats; Disease trans mis sion, infec tious; Potassium iodi de; Sporotrichosis Resumo: A espo ro tri co se é mico se suba gu da ou crô ni ca, cau sa da pelo fungo dimór fi co Sporothrix schenckii, endê mi ca no Brasil e trans mi ti da prin ci pal men te atra vés da ino cu la ção trau má ti ca de seu agen te cau sal na pele. A trans mis são zoo nó ti ca, espe cial men te por gatos infec ta dos, tem sido demons tra da em diver sos rela tos e séries de casos. Nós des cre ve mos a ocor rên cia simul tâ nea da doen ça em três mem bros de uma mesma famí lia atra vés da arra nha du ra por gato domés ti co infec ta do. Dois pacien tes desen vol ve ram a forma cutâ nea-lin fá ti ca e ape nas um desen vol veu a forma cutâ nea fixa. Dois pacien tes foram tra ta dos com sucesso, com solu ção satu ra da de iode to de potás sio; entre tan to, o ter cei ro caso apre sen tou efei tos cola te rais e teve seu tra ta men to subs ti tuí do por itra co na zol, com reso lu ção de suas lesões. Palavras-chave: Esporotricose; Gatos; Iodeto de potás sio; Transmissão de doen ça infec cio sa

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Esporotricose do gato doméstico (Felis catus): transmissão humana

Cited by 39 publications

References 8 publications

Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

Características clínico-epidemiológicas, histomorfológicas e histoquímicas da esporotricose felina

A Case of Feline Sporotrichosis

Ocorrência familiar de esporotricose zoonótica

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