Patogênese da miocardite chagásica crônica: o papel de fatores autoimunes e microvasculares

Rossi, Marcos A.; Mengel, José

doi:10.1590/s0036-46651992000600015

Cited by 12 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ela também pode ser decorrente de outros mecanismos, como a resposta imunológica, incluindo a celular e humoral (Pascon et al 2010), com consequentes lesões miocárdicas tanto na fase aguda como crônica (Rossi & Mengel 1992). Nos cães que apresentaram valores de CK e CK-MB acima dos níveis normais pode sugerir lesão cardíaca (Souza et al 2008) e, apesar, da dosagem por quimioluminescência de cTnI, ser considerada mais sensível e especíϐica que a CK-MB, esta apresentou valores normais devido sua maior presteza em diagnóstico de lesões agudas que nas crônicas (Tarducci et al 2004).…”

Section: Animais Leuc (Ul) Ns (%) Ns (Abs) Nb (%) Nb (Abs) Eos (%) Eounclassified

See 1 more Smart Citation

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

et al. 2012

View full text Add to dashboard Cite

This study aimed to evidence the clinical and laboratorial signs of this disease to help characterize this illness in a natural way in the semiarid in the northeastern region. We evaluated 10 positive for Trypanosoma cruzi dogs, that were identiϐied by serological analysis of immunoϐluorescence assay (RIFI) and enzyme linked immunosorbent assay (ELISA); molecular analysis by polymerase chain reaction (PCR), direct microscopy and blood culture. The chagasic dogs underwent physical examination, electrocardiographic, radiographic, blood pressure, hematology (erythrocyte and leukocyte count) and biochemical exams (urea, creatinine, ALT, AST, PT, albumin, globulin, CK, CK-MB, and cTnl). The physical examination and the blood pressure were presented within the normal range, while in the electrocardiography the FC was observed as normal with a sinus rhythm, with the exception of one dog that presented a sinus tachycardia (168 bat/min). In the ECG of eight dogs there was increase of duration of P (47+6.5ms) suggestive to atrial enlargement, not conϐirmed in the radiography. A supraunlevelling was observed in the ST segment in one dog. In the hematological results, thrombocytopenia (187.4x10 3 +137.2x10 3 ) and anemia (5.0x10 6 +1.39x10 6 /ul) were noted. The mean hemoglobin (11 +2.7g/dL), hematocrit (34+10.5%) were below normal limits. The white series were within normal variation, with the exception of eosinophilia observed in three dogs. Individually, there were two dogs which registered leukocytosis, lymphocytosis and neutrophilia. In the biochemical evaluation there was hyperproteinemia PT=7.2 +0.9g/dL, hypoalbuminemia (2.2+0.4g/dL), hyperglobulinemia (5.1+1.0g/dL), increased of CK (196+171 U/L) and there was no alteration on ALT and AST enzymes. The CK-MB isoenzymes and cTnI did not change, except in three dogs. We conclude that dogs naturally infected in the northeastern semiarid present characteristics related to indeterminate chronic form (asymptomatic dogs) and that the identiϐication of the naturally infected dogs with no pathognomonic characteristics of the Chagas disease underscores the importance of this illness in the diagnostic process with the other proϐiles that show nonspeciϐic or not associated to cardiovascular disease.INDEX TERMS: Heart disease, parasite, Trypanosoma cruzi, Chagas disease, diseases of dog, parasitology.

show abstract

Section: Animais Leuc (Ul) Ns (%) Ns (Abs) Nb (%) Nb (Abs) Eos (%) Eounclassified

“…Em pacientes humanos, as manifestações clínicas se intensiϐicam, com cardiomegalia leve a moderada, evoluindo para insuϐiciência cardíaca congestiva acompanhada de aumento cardíaco grave, fenômenos tromboembólicos e arritmias graves nos estágios ϐinais (Rossi & Mengel 1992).…”

Section: Introductionunclassified

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Sudden death is a constant risk at any clinical stage, occurring in one to two thirds of patients who die due to CD. Although most of these patients presented prior CI, about one third to one fifth of sudden deaths occur in asymptomatic CD patients [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease

et al. 2016

View full text Add to dashboard Cite

Chagas disease (CD) is caused by Trypanosoma cruzi, whose sugar moieties are recognized by mannan binding lectin (MBL), a soluble pattern-recognition molecule that activates the lectin pathway of complement. MBL levels and protein activity are affected by polymorphisms in the MBL2 gene. We sequenced the MBL2 promoter and exon 1 in 196 chronic CD patients and 202 controls. The MBL2*C allele, which causes MBL deficiency, was associated with protection against CD (P = 0.007, OR = 0.32). Compared with controls, genotypes with this allele were completely absent in patients with the cardiac form of the disease (P = 0.003). Furthermore, cardiac patients with genotypes causing MBL deficiency presented less heart damage (P = 0.003, OR = 0.23), compared with cardiac patients having the XA haplotype causing low MBL levels, but fully capable of activating complement (P = 0.005, OR = 7.07). Among the patients, those with alleles causing MBL deficiency presented lower levels of cytokines and chemokines possibly implicated in symptom development (IL9, p = 0.013; PDGFB, p = 0.036 and RANTES, p = 0.031). These findings suggest a protective effect of genetically determined MBL deficiency against the development and progression of chronic CD cardiomyopathy.

show abstract

“…According to some authors 30–31 , the marked decrease in the cardiac neuronal population at the several evolution phases of the disease 18, 32–35 , although it does not constitute a primary and independent lesion mechanism, suggests specificity of this process in the infection by T. cruzi and can contribute as a secondary and amplifying mechanism of the lesion caused by the inflammatory process 21 .…”

Section: Introductionmentioning

confidence: 99%

Envolvimento de auto-anticorpos na fisiopatologia da Doença de Chagas

Medei¹,

Nascimento

Pedrosa

et al. 2008

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

Summary Chagas’ disease is a serious health problem in Latin America. Between 25 to 30% of the infected patients develop the chronic form of the disease, with progressive myocardial damage and often, sudden death. Adrenergic or cholinergic antibodies with G-protein coupled membrane receptor activity may be present in the sera of these patients. The present study discusses the etiology and the contribution of antibodies to the physiopathology of Chagas’ disease.

show abstract

Patogênese da miocardite chagásica crônica: o papel de fatores autoimunes e microvasculares

Cited by 12 publications

References 34 publications

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

Genetically Determined MBL Deficiency Is Associated with Protection against Chronic Cardiomyopathy in Chagas Disease

Envolvimento de auto-anticorpos na fisiopatologia da Doença de Chagas

Contact Info

Product

Resources

About