Schistosoma mansoni: preclinical studies with 9-acridanone-hydrazones in Cebus monkeys experimentally infected

Coelho, Paulo Marcos Zech; Pereira, Leandro de Mattos

doi:10.1590/s0036-46651991000100010

Cited by 8 publications

(2 citation statements)

References 13 publications

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“…Thus, it has been utilized since its establishment for the screening of new anti-schistosomal drugs, in the research and clinical control of schistosomiasis. In both cases its usefulness has already been thoroughly demonstrated (Pellegrino et al , 1962; Cunha et al , 1963, 1987; Cançado et al , 1965; Pellegrino & Faria, 1965; Katz et al , 1966; Katz & Pellegrino, 1974; Cunha, 1982; Coelho & Pereira, 1991; Araújo et al , 1999).…”

Section: Introductionmentioning

confidence: 97%

Current applications of oogram methodology in experimental schistosomiasis; fecundity of femaleSchistosoma mansoniand egg release in the intestine of AKR/J mice following immunomodulatory treatment with pentoxifylline

Mati

Melo

2012

J. Helminthol.

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AbstractOogram methodology permitted a direct assessment of the fecundity ofSchistosoma mansoniand the passage of parasite eggs from mesenteric vessels into the intestinal lumen in AKR/J mice that had been infected via the intraperitoneal route with 60 cercariae of the trematode and later subjected to short-term subcutaneous treatments with pentoxifylline (PTX). The administration of PTX did not change oviposition kinetics, the individual fecundity of female parasites (as determined by the study of the ratio of second-stageS. mansonieggs per g intestine/number of female parasites recovered from the portal system), nor the number of mature and dead eggs retained in the host tissue, though the drug has known immunomodulatory effects, as shown previously in experimental schistosomiasis. A better appraisal was also carried out, including the study of statistical parameters, concerning the utilization of the ratios of each stage of immature eggs (first to fourth) per g intestine/number of female worms from the portal system. The second-stage eggs had the lowest variability, confirming that the utilization of this stage as an indicator of the individual fecundity of parasite females is indeed viable. In the light of our findings, current uses of oogram methodology are discussed. Moreover, additional consideration is given to data obtained in the present study concerning intraperitoneal infection withS. mansonicercariae in both untreated and treated mice of the AKR/J strain, such as the recovery of mature worms, eggs and free granulomas from the peritoneal cavity of these rodents.

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Section: Introductionmentioning

confidence: 97%

Current applications of oogram methodology in experimental schistosomiasis; fecundity of femaleSchistosoma mansoniand egg release in the intestine of AKR/J mice following immunomodulatory treatment with pentoxifylline

Mati

Melo

2012

J. Helminthol.

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“…Moreover, 9-acridanone-hydrazones proved to be active against Schistosoma mansoni 7 and quinoxaline-Nacylhydrazones showed trypanocidal activity. 8 In addition, methyl pyrazinylketone isonicotinoyl hydrazones have been synthesized in an attempt to develop novel chelators with high affinity for iron for the treatment of iron overload disease.…”

Section: Introductionmentioning

confidence: 99%