Rickettsiosis cutáneo ganglionar por Rickettsia conorii en el Uruguay

Conti‐Díaz, I.A.; Rubio, Ivonne; Moreira, Raúl E. Somma; Bormida, G.

doi:10.1590/s0036-46651990000500001

Cited by 34 publications

(23 citation statements)

References 4 publications

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“…Preliminary studies also suggest that A. cajennense will support the growth and survival of R. parkeri (303), and a recent investigation has demonstrated DNA of R. parkeri in Amblyomma triste (formerly A. maculatum) ticks collected from humans and animals in Uruguay (347). These findings, coupled with other reports of escharassociated spotted fever rickettsioses in patients following bites of A. triste in Uruguay (73,87), suggests that R. parkeri rickettsiosis also occurs in areas of South America. In Uruguay, it is likely that rickettsiosis caused by R. parkeri has been diagnosed as infection with R. conorii based on nonspecific serologic tests (87).…”

Section: Vol 18 2005mentioning

confidence: 70%

“…For example, a SFG rickettsioses initially described in Uruguay in 1990 was observed in three patients who presented with fever, a small initial maculopapulous lesion on the scalp at a tick bite site followed by regional lymphadenopathy. MIF serology using R. conorii as the sole antigen was positive for all patients, and these infections were presumptively identified as spotted fever caused by R. conorii (73). During 1993During -1994 patients with a previous history of tick bite, including some with exanthems and inoculation eschars were identified from rural areas of Canelones County, Uruguay.…”

Section: Serologymentioning

confidence: 99%

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Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts

2005

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SUMMARY During most of the 20th century, the epidemiology of tick-borne rickettsioses could be summarized as the occurrence of a single pathogenic rickettsia on each continent. An element of this paradigm suggested that the many other characterized and noncharacterized rickettsiae isolated from ticks were not pathogenic to humans. In this context, it was considered that relatively few tick-borne rickettsiae caused human disease. This concept was modified extensively from 1984 through 2005 by the identification of at least 11 additional rickettsial species or subspecies that cause tick-borne rickettsioses around the world. Of these agents, seven were initially isolated from ticks, often years or decades before a definitive association with human disease was established. We present here the tick-borne rickettsioses described through 2005 and focus on the epidemiological circumstances that have played a role in the emergence of the newly recognized diseases.

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Section: Vol 18 2005mentioning

confidence: 70%

Section: Serologymentioning

confidence: 99%

Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts

2005

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“…In this last country, a number of cases of rickettsiosis, often referred as cutaneous-ganglionar rickettsiosis, have been reported since 1990, characterized by a small papulo-nodular lesion at the tick attachment site, an influenza-like illness (fever, headache, malaise), and regional lymphadenopathy in all observed cases; some cases also presented generalized rash. No further clinical complication was observed 3,4,5 . Ticks associated with these cases were initially misidentified as A. maculatum and the rickettsial agent was prematurely identified as R. conorii.…”

Section: Introductionmentioning

confidence: 98%

Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay

Conti‐Díaz¹,

Moraes‐Filho

Pacheco

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SUMMARYWe report three new rickettsiosis human cases in Uruguay. The three clinical cases presented clinical manifestations similar to previous reported cases of Rickettsia parkeri in the United States; that is mild fever (< 40 o C), malaise, headache, rash, inoculation eschar at the tick bite site, regional lymphadenopathy, and no lethality. Serological antibody-absorption tests with purified antigens of R. parkeri and Rickettsia rickettsii, associated with immunofluorescence assay indicated that the patients in two cases were infected by R. parkeri. Epidemiological and clinical evidences, coupled with our serological analysis, suggest that R. parkeri is the etiological agent of human cases of spotted fever in Uruguay, a disease that has been recognized in that country as cutaneous-ganglionar rickettsiosis.

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“…The history of spotted fever group (SFG) rickettsiosis in Uruguay is rather complex. The first three autochthonous cases of human rickettsiosis were diagnosed by Indirect Fluorescent Antibody Test (IFAT) 5 . Rickettsia conorii, the agent of Mediterranean spotted fever (MSF) was implicated as the causative agent, and the tick Amblyomma maculatum was found attached to at least one of the patients 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The first three autochthonous cases of human rickettsiosis were diagnosed by Indirect Fluorescent Antibody Test (IFAT) 5 . Rickettsia conorii, the agent of Mediterranean spotted fever (MSF) was implicated as the causative agent, and the tick Amblyomma maculatum was found attached to at least one of the patients 5 . The natural vector and potential reservoir of R. conorii in the Old World is the R. sanguineus group, implicated in the transmission of other Rickettsia species affecting humans 23,34 .…”

Section: Introductionmentioning

confidence: 99%

Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay

Venzal

Estrada-Peña

Portillo

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYAt first Rickettsia conorii was implicated as the causative agent of spotted fever in Uruguay diagnosed by serological assays. Later Rickettsia parkeri was detected in human-biting Amblyomma triste ticks using molecular tests. The natural vector of R. conorii, Rhipicephalus sanguineus, has not been studied for the presence of rickettsial organisms in Uruguay. To address this question, 180 R. sanguineus from dogs and 245 A. triste from vegetation (flagging) collected in three endemic localities were screened for spotted fever group (SFG) rickettsiosis in southern Uruguay. Tick extracted DNA pools were subjected to PCR using primers which amplify a fragment of the rickettsial gltA gene. Positive tick DNA pools with these primers were subjected to a second PCR round with primers targeting a fragment of the ompA gene, which is only present in SFG rickettsiae. No rickettsial DNA was detected in R. sanguineus. However, DNA pools of A. triste were found to be positive for a rickettsial organism in two of the three localities, with prevalences of 11.8% to 37.5% positive pools. DNA sequences generated from these PCR-positive ticks corresponded to R. parkeri. These findings, joint with the aggressiveness shown by A. triste towards humans, support previous data on the involvement of A. triste as vector of human infections caused by R. parkeri in Uruguay.

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Rickettsiosis cutáneo ganglionar por Rickettsia conorii en el Uruguay

Cited by 34 publications

References 4 publications

Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts

Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts

Serological evidence of Rickettsia parkeri as the etiological agent of rickettsiosis in Uruguay

Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay

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