Freqüência de anticorpos neutralizantes contra o vesiculovirus Piry, em doadores de sangue de Uberaba , Minas Gerais, Brasil

Background The detection of the first cases of transfusion-transmitted West Nile virus in 2002 posed a new challenge for transfusion safety. Institutions like the World Health Organization have stated that blood transfusion centers need to know the epidemiology of the different emerging infectious agents and their impact on blood transfusion. The aim of the study is to review the published cases of arbovirus transmission through transfusion of blood or blood components and to analyze their main clinical and epidemiological characteristics. Material and methods Systematic literature searches were conducted in MEDLINE, Embase and Scopus. Pairs of review authors selected a variety of scientific publications reporting cases of transfusion-transmitted arboviruses. Main clinical and epidemiological characteristics were reviewed of the cases described. The study protocol was registered in PROSPERO CRD42021270355. Results A total of 74 cases of transfusion-transmitted infections were identified from 10 arboviruses: West Nile virus (n = 42), dengue virus (n = 18), Zika virus (n = 3), yellow fever vaccine virus (n = 3), tick-borne encephalitis virus (n = 2), Japanese encephalitis virus (n = 2), Powassan virus (n = 1), St. Louis encephalitis virus (n = 1), Ross River virus (n = 1) and Colorado tick fever virus (n = 1). The blood component most commonly involved was red blood cells (N = 35, 47.3%; 95% confidence interval [CI] 35.9% to 58.7%). In 54.1% (N = 40; 95% CI: 42.7%-65.47%) of the cases, the recipient was immunosuppressed. Transmission resulted in death in 18.9% (N = 14; 95% CI: 10.0%-27.8%) of the recipients. In addition, 18 additional arboviruses were identified with a potential threat to transfusion safety. Discussion In the last 20 years, the number of published cases of transfusion-transmitted arboviruses increased notably, implicating new arboviruses. In addition, a significant number of arboviruses that may pose a threat to transfusion safety were detected. In the coming years, it is expected that transmission of arboviruses will continue to expand globally. It is therefore essential that all responsible agencies prepare for this potential threat to transfusion safety.

show abstract

“…Tavares-Neto 1990 [81] Original article Screening in blood donors: frequency of neutralizing antibodies 8% (13/162).…”

Section: Vesiculovirus Pirymentioning

confidence: 99%

Transfusion-transmitted arboviruses: Update and systematic review

Giménez-Richarte¹,

Salazar²,

Giménez-Richarte³

et al. 2022

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…Precocemente na infecção aguda, e de forma marcante na fase de convalescença, aparecem os anticorpos neutralizantes, os quais permanecem por longos períodos ou por toda a vida 9 . No Brasil, a freqüência dos indivíduos com anticorpos neutralizantes anti-Piry varia de 0 a 40,2% 8,11,25,31,32 . Em indivíduos adultos de Catolândia-Bahia, em estudo sorológico preliminar, a freqüência dos anticorpos neutralizantes anti-Piry foi de 33,3% 33 , detectados pelo teste de neutralização em camundongos (TN-camundongos).…”

unclassified

Comparação de dois testes de neutralização, utilizados no diagnóstico sorológico do vesiculovírus Piry

et al. 1993

Self Cite

View full text Add to dashboard Cite

. Precocemente na infecção aguda, e de forma marcante na fase de convalescença, aparecem os anticorpos neutralizantes, os quais permanecem por longos períodos ou por toda a vida 9 . No Brasil, a freqüência dos indivíduos com anticorpos neutralizantes anti-Piry varia de 0 a 40,2% 8,11,25,31,32 . Em indivíduos adultos de Catolândia-Bahia, em estudo sorológico preliminar, a freqüência dos anticorpos neutralizantes anti-Piry foi de 33,3% 33 , detectados pelo teste de neutralização em camundongos (TN-camundongos). Entretanto, apesar de ser o teste-padrão, a realização deste método requer grande número de camundongos recém-nascidos, o que limita sua aplicação em estudos soroepidemiológicos.De modo geral os vesiculovírus não replicam tão intensamente nas células de vertebrados como nas de mosquitos 13,14,17,34 . O vírus Piry, como ocorre com vá-rios arbovírus, apresentou replicação evidente em célu-las do clone C6/36 do Aedes albopictus 12 . Porém, as infecções pelo Piry não produzem efeito citopático

show abstract

Complete genome sequence of Piry vesiculovirus

et al. 2016

View full text Add to dashboard Cite

Piry virus (PIRYV) is a rhabdovirus (genus Vesiculovirus) and is described as a possible human pathogen, originally isolated from a Philander opossum trapped in Para State, Northern Brazil. This study describes the complete full coding sequence and the genetic characterization of PIRYV. The genome sequence reveals that PIRYV has a typical vesiculovirus-like organization, encoding the five genes typical of the genus. Phylogenetic analysis confirmed that PIRYV is most closely related to Perinet virus and clustered in the same clade as Chandipura and Isfahan vesiculoviruses.

show abstract

Freqüência de anticorpos neutralizantes contra o vesiculovirus Piry, em doadores de sangue de Uberaba , Minas Gerais, Brasil

Cited by 7 publications

References 3 publications

Transfusion-transmitted arboviruses: Update and systematic review

Transfusion-transmitted arboviruses: Update and systematic review

Comparação de dois testes de neutralização, utilizados no diagnóstico sorológico do vesiculovírus Piry

Complete genome sequence of Piry vesiculovirus

Contact Info

Product

Resources

About