Caso fatal de adiaspiromicose pulmonar humana

Moraes, Mário Augusto Pinto de; Almeida, Marcos Célio de; Raick, Alberto N.

doi:10.1590/s0036-46651989000300009

Cited by 18 publications

(11 citation statements)

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“…Approximately 67 probable cases of human pulmonary adiaspiromycosis due to E. crescens have been described in the literature. England and Hochholzer, in their 1993 case series and review (21), identified 46 cases; there have been 20 other cases reported since that time or that were omitted from the England and Hochholzer review (6,11,13,15,31,32,36,37,38,40,50,51,52,56,60,62) (Table 1). Adiaspiromycosis may be discovered incidentally after histopathologic exam of the lung for other conditions.…”

Section: Resultsmentioning

confidence: 99%

“…In such cases, the chest radiograph usually shows bilateral reticulonodular infiltrates suggestive of miliary tuberculosis. Disseminated pulmonary infection can have a severe or even fatal course (4,6,21,31,36,39,45,52,56). The patient reported herein suffered moderate restrictive lung disease after the infection, as observed in two prior cases (cases 13 and 14 from Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Previous cases of adiaspiromycosis have been reported from North America (Guatemala, Honduras, and the United States [Arizona, Georgia, North Carolina, New York, and Oklahoma]), South America (Argentina, Brazil, and Venezuela), and Europe (the former Czechoslovakia, France, Germany, and the former Soviet Union, Spain) (21,53). New countries from which the disease has been reported are Finland and the United Kingdom (13, 40); however, 62% of the 21 new cases from Table 1 were reported from Brazil (11,31,36,37,38,50,51,56). It is unclear if E. crescens is more common in Brazil or if this is simply reporting bias.…”

Section: Frommentioning

confidence: 99%

“…The most appropriate treatment for adiaspiromycosis is unknown (71). Many human cases are self-limited or asymptomatic, but several cases that have resulted in respiratory failure (including death) have been reported (4,6,21,31,36,45,52,56). In the cases of adiaspiromycosis reported in Table 1, 57% of the patients were treated with an antifungal agent.…”

Section: Frommentioning

confidence: 99%

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Adiaspiromycosis Causing Respiratory Failure and a Review of Human Infections Due to Emmonsia and Chrysosporium spp

2012

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bWe report a case of a 27-year-old male who presented with respiratory distress that required mechanical ventilation. Transbronchial biopsy revealed adiaspores of the fungus Emmonsia crescens within granulomata, a condition known as adiaspiromycosis. The patient received amphotericin products and corticosteroids, followed by itraconazole, and made a full recovery. Emmonsia crescens is a saprobe with a wide distribution that is primarily a rodent pathogen. The clinical characteristics of the 20 cases of human pulmonary adiaspiromycosis reported since the last comprehensive case review in 1993 are described here, as well as other infections recently reported for the genus Emmonsia. Pulmonary adiaspiromycosis has been reported primarily in persons without underlying host factors and has a mild to severe course. It remains uncertain if the optimal management of severe pulmonary adiaspiromycosis is supportive or if should consist of antifungal treatment, corticosteroids, or a combination of the latter two. The classification of fungi currently in the genus Emmonsia has undergone considerable revision since their original description, including being grouped with the genus Chrysosporium at one time. Molecular genetics has clearly differentiated the genus Emmonsia from the Chrysosporium species. Nevertheless, there has been a persistent confusion in the literature regarding the clinical presentation of infection with fungi of these two genera; to clarify this matter, the reported cases of invasive Chrysosporium infections were reviewed. Invasive Chrysosporium infections typically occur in impaired hosts and can have a fatal course. Based on limited in vitro susceptibility data for Chrysosporium zonatum, amphotericin B is the most active drug, itraconazole susceptibility is strain-dependent, and fluconazole and 5-fluorocytosine are not active.A diaspiromycosis is primarily a pulmonary infection of rodents, fossorial mammals, and their predators and is caused by the soil fungi Emmonsia crescens and Emmonsia parva (17,30,35,53). It is a rare human infection. In this infection, inhaled Emmonsia conidia enlarge to form nonreplicating adiaspores. As in other mammals, the infection in humans usually involves the lungs, with only a few other cases of infection at other sites (17,30,35,53). About 70 cases of human adiaspiromycosis have been described, but much of the literature on this infection has been dispersed in less-accessible, non-English journals. Furthermore, the inconsistent nomenclature and taxonomy of Emmonsia species and their confusion with Chrysosporium species has resulted in an overall lack of consistent information on adiaspiromycosis and Chrysosporium infections. Herein, we report a case of adiaspiromycosis that resulted in respiratory failure. We also review the true cases of adiaspiromycosis that have been reported since the seminal monographs of England and Hochholzer in 1993 (21) and Sigler in 2005 (53) or omitted from those reports. Furthermore, we differentiate the cases of adiaspiromycosis from the tr...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Frommentioning

confidence: 99%

Section: Frommentioning

confidence: 99%

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Adiaspiromycosis Causing Respiratory Failure and a Review of Human Infections Due to Emmonsia and Chrysosporium spp

2012

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“…In our cases, clinical complaints started from August to December, which is a period characterized by warm dry climate and high winds 19 . Two of the patients were cigarette smokers.…”

Section: Discussionmentioning

confidence: 81%

Pulmonary adiaspiromycosis: report of two cases

Santos

Fatureto

Saldanha

et al. 2000

Rev. Soc. Bras. Med. Trop.

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Two cases of human pulmonary adiaspiromycosis are reported. Patients were 29 and 54-year-old males, farm workers, with "grippe-like" symptoms and radiographic findings suggestive of granulomatous interstitial disease. Transthoracoscopic and transbronchial biopsies were performed. Pulmonary function was measured by spirometry. One patient used ketoconazole. Possibility of misdiagnosed pulmonary adiaspiromycosis is emphasized. Key-words: Pulmonary mycosis. Adiaspiromycosis. Emmonsia parva var crescens. Chrysosporium parvum var crescens. Pulmonary biopsy. Spirometry.Resumo Relatam-se casos de adiaspiromicose pulmonar em homens brancos de 29 e 54 anos, lavradores, com sintomas "gripais" e achados radiológicos sugestivos de doença granulomatosa intersticial. Biópsias transbrônquicas e transtoracoscópicas foram realizadas. A função pulmonar foi avaliada por espirometria. Um paciente usou cetoconazol. Enfatizam-se possibilidades de confusão diagnóstica na adiaspiromicose pulmonar.

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Les champignons des genres Acremonium, Beauveria, Chrysosporium, Fusarium, Onychocola, Paecilomyces, Penicillium, Scedosporium et Scopulariopsis responsables de hyalohyphomycoses

Hocquette

Grondin

Bertout

et al. 2005

Journal de Mycologie Médicale

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Caso fatal de adiaspiromicose pulmonar humana

Abstract: RESUMOÉ descrito um caso fatal de adiaspiromicose pulmonar, em paciente do sexo masculino, lavrador, que vivia em Planaltina-DF, para onde se mudara, vindo do Nordeste, cerca de um ano antes do aparecimento da enfermidade.

Cited by 18 publications

References 11 publications

Adiaspiromycosis Causing Respiratory Failure and a Review of Human Infections Due to Emmonsia and Chrysosporium spp

Adiaspiromycosis Causing Respiratory Failure and a Review of Human Infections Due to Emmonsia and Chrysosporium spp

Pulmonary adiaspiromycosis: report of two cases

Les champignons des genres Acremonium, Beauveria, Chrysosporium, Fusarium, Onychocola, Paecilomyces, Penicillium, Scedosporium et Scopulariopsis responsables de hyalohyphomycoses

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